GENE：ITPR2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ITPR2 |
| FullNmae | inositol 1,4,5-trisphosphate receptor type 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6181 |
| EnsembleID | ENSG00000123104 |
| Uniprot | Q14571 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ITPR2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ITPR2 | GO:0001666,GO:0005220,GO:0005220,GO:0005509,GO:0005654,GO:0005783,GO:0005789,GO:0005789,GO:0005886,GO:0005886,GO:0005938,GO:0007165,GO:0015085,GO:0016020,GO:0016529,GO:0030667,GO:0031095,GO:0033017,GO:0035091,GO:0043235,GO:0044325,GO:0051209,GO:0051209,GO:0070679,GO:0071320,GO:0071361,GO:0097110 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ITPR2 | hsa:3709 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04210 | Apoptosis - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04218 | Cellular senescence - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04540 | Gap junction - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04611 | Platelet activation - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04720 | Long-term potentiation - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04730 | Long-term depression - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04924 | Renin secretion - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04927 | Cortisol synthesis and secretion - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04928 | Parathyroid hormone synthesis, secretion and action - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04929 | GnRH secretion - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04934 | Cushing syndrome - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04935 | Growth hormone synthesis, secretion and action - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04970 | Salivary secretion - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04971 | Gastric acid secretion - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa04972 | Pancreatic secretion - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa05010 | Alzheimer disease - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa05012 | Parkinson disease - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa05017 | Spinocerebellar ataxia - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa05020 | Prion disease - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa05022 | Pathways of neurodegeneration - multiple diseases - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa05131 | Shigellosis - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa05167 | Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa05170 | Human immunodeficiency virus 1 infection - Homo sapiens (human) |
| ITPR2 | hsa:3709 | path:hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AHCYL1 | ITPR2 | 11904675 16754674 29145629 | physical association | inferred by curator | Reactome |
| ITPR2 | ITPR1 | 17429043 24243840 29145629 | physical association | inferred by curator | Reactome |
| ITPR2 | ITPR3 | 17429043 24243840 29145629 | physical association | inferred by curator | Reactome |
| ITPR2 | ITPR2 | 17429043 24243840 29145629 | physical association | inferred by curator | Reactome |
| STIM1 | ITPR2 | 18187424 18596693 19249086 29145629 | enzymatic reaction | inferred by curator | Reactome |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ITPR2 | 18971253 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ETS1 | ITPR2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | ITPR2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | ITPR2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| MYCN | ITPR2 | 16093321 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | ITPR2 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | ITPR2 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | ITPR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ITPR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ITPR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ITPR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | ITPR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ITPR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ITPR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ITPR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ITPR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ITPR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | ITPR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | ITPR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | ITPR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | ITPR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | ITPR2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | ITPR2 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000033EBB8 | ITPR2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000070B1D | ITPR2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000005481D | ITPR2 | 19536157 23622248 25416803 | mrna cleavage,inhibition | clip,clash | TarBase |
| URS00001EB9FC | ITPR2 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075E2C3 | ITPR2 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CA8 | ITPR2 | 25348397 | N/A | physical interaction | ComPPI |
| PSMC3 | ITPR2 | 25348397 | N/A | physical interaction | ComPPI |
| TAFA4 | ITPR2 | 25348397 | N/A | physical interaction | ComPPI |
| BANK1 | ITPR2 | 11782428 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| PRKACA | ITPR2 | 11694504 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| TRPC1 | ITPR2 | 10970773 11336651 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| TRPC4 | ITPR2 | 11163362 14525934 24234451 25348397 | physical association | two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD,IntAct |
| ITPR2 | NXF1 | 25348397 | N/A | physical interaction | ComPPI |
| ITPR2 | CCDC8 | 25348397 | N/A | physical interaction | ComPPI |
| ITPR2 | CACNG2 | 25348397 | N/A | physical interaction | ComPPI |
| ITPR2 | P2RY12 | 25348397 | N/A | physical interaction | ComPPI |
| ITPR2 | TESPA1 | 25348397 | N/A | physical interaction | ComPPI |
| ITPR2 | LPAR1 | 25348397 | N/A | physical interaction | ComPPI |
| ITPR2 | HERC2 | 25348397 | N/A | physical interaction | ComPPI |
| ITPR2 | HERC2P3 | 25348397 | N/A | physical interaction | ComPPI |
| ITPR2 | CAPZA2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ITPR2 | MYH9 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ITPR2 | NUP107 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ITPR2 | CTDNEP1 | 25348397 | N/A | physical interaction | ComPPI |
| ITPR2 | RAB29 | 25348397 | N/A | physical interaction | ComPPI |
| ITPR2 | L3MBTL2 | 25348397 | N/A | physical interaction | ComPPI |
| ITPR2 | ZNRF4 | 25348397 | N/A | physical interaction | ComPPI |
| ITPR2 | CHRNA3 | 25348397 | N/A | physical interaction | ComPPI |
| ITPR2 | IPPK | 25348397 | N/A | physical interaction | ComPPI |
| BBOX1 | ITPR2 | 25348397 | N/A | physical interaction | ComPPI |
| EIF4G1 | ITPR2 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| TRPC3 | ITPR2 | 16899571 27898060 | N/A | N/A | OmniPath |
| ITPR2 | TRPC1 | 10970773 11336651 12196544 15121806 16870612 16905188 17681754 18068335 18191041 18249094 23228564 27898060 | stimulant | N/A | OmniPath |