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GENE：CTSG

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CTSG
FullNmae cathepsin G
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2532
EnsembleID ENSG00000100448
Uniprot P08311

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CTSG lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
CTSG lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
CTSG immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CTSG ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CTSG GO:0002003,GO:0002548,GO:0004252,GO:0004252,GO:0004252,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005634,GO:0005634,GO:0005737,GO:0005764,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0006468,GO:0006508,GO:0006955,GO:0008201,GO:0008233,GO:0008233,GO:0008236,GO:0010494,GO:0016020,GO:0016485,GO:0019221,GO:0019538,GO:0019731,GO:0022617,GO:0030141,GO:0030168,GO:0035578,GO:0035590,GO:0042119,GO:0043231,GO:0048018,GO:0050778,GO:0050829,GO:0050830,GO:0050832,GO:0050868,GO:0062023,GO:0070062,GO:0070946,GO:0071222,GO:0089720,GO:0098786,GO:1901731

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CTSG hsa:1511 path:hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
CTSG hsa:1511 path:hsa04142 Lysosome - Homo sapiens (human)
CTSG hsa:1511 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
CTSG hsa:1511 path:hsa04614 Renin-angiotensin system - Homo sapiens (human)
CTSG hsa:1511 path:hsa05146 Amoebiasis - Homo sapiens (human)
CTSG hsa:1511 path:hsa05322 Systemic lupus erythematosus - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CTSG CASP7 15650747 23180781 cleavage reaction protease assay InnateDB
CTSG CAMP 11389039 23180781 cleavage reaction protease assay InnateDB
CTSG ERBIN 15123239 23180781 physical association peptide array InnateDB
CTSG SPINK5 22588119 23180781 physical association protein array InnateDB
CCL14 CTSG 16034099 23180781 protein cleavage protease assay InnateDB
CTSG C3 23180781 24315997 physical association protease assay InnateDB
IL33 CTSG 22307629 23180781 protein cleavage mass spectrometry studies of complexes,protease assay InnateDB

Source Target Pmid Interactiontype Methods Database
CEBPE CTSG 16019164 trascriptional regulation,stimulation inferred by curator TFlink
MYB CTSG 16019164 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CTSG 16019164 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 CTSG 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR CTSG 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
CTSG SDC1 25361965 interaction type N/A PTMCode2
SDC1 CTSG 25361965 interaction type N/A PTMCode2
CTSG THBS1 25361965 interaction type N/A PTMCode2
THBS1 CTSG 25361965 interaction type N/A PTMCode2
CTSG SERPINA3 25361965 interaction type N/A PTMCode2
SERPINA3 CTSG 25361965 interaction type N/A PTMCode2
CTSG KNG1 25361965 interaction type N/A PTMCode2
KNG1 CTSG 25361965 interaction type N/A PTMCode2
CTSG PPBP 25361965 interaction type N/A PTMCode2
PPBP CTSG 25361965 interaction type N/A PTMCode2
CTSG F2RL1 25361965 interaction type N/A PTMCode2
F2RL1 CTSG 25361965 interaction type N/A PTMCode2
CTSG F2R 25361965 interaction type N/A PTMCode2
F2R CTSG 25361965 interaction type N/A PTMCode2
CTSG AGT 25361965 interaction type N/A PTMCode2
AGT CTSG 25361965 interaction type N/A PTMCode2
SERPIND1 CTSG 25361965 interaction type N/A PTMCode2
CTSG SERPIND1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TCF25 CTSG 25348397 N/A physical interaction ComPPI
RAD21 CTSG 25348397 N/A physical interaction ComPPI
KRT31 CTSG 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CTSG SERPINA3 10512690 14525934 25348397 27898060 8849841 9698370 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
CTSG C3 14525934 1861080 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSG IGFBP3 10512690 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CTSG PARP1 11536009 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
CTSG SDC1 14525934 25348397 9565572 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CTSG THBS1 14525934 25348397 8408036 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSG F5 14525934 25348397 27898060 9718313 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
CTSG KNG1 11920276 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSG CAMP 25348397 N/A in vitro,in vivo ComPPI
CTSG CXCL12 11241273 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CTSG F2RL1 10978167 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSG F2RL2 11307827 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CTSG SERPINB13 12504904 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSG PPBP 1387511 14525934 1873479 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSG F2R 10978167 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSG SELPLG 11520793 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
CTSG CXCR4 12531874 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSG VCAM1 11520773 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSG CASP7 14525934 15650747 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSG SERPINA1 14525934 15131125 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSG LRP1 14525934 15131125 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSG AGT 10899625 11747312 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CTSG FN1 25348397 N/A protease assay ComPPI
CTSG ERBIN 25348397 N/A physical interaction ComPPI
CTSG SERPINB4 25348397 N/A physical interaction ComPPI
CTSG NOTCH2NLA 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CTSG GPRASP2 25348397 N/A physical interaction ComPPI
CTSG YTHDF1 25348397 N/A physical interaction ComPPI
CTSG FREM2 25348397 N/A physical interaction ComPPI
CTSG WIZ 25348397 N/A physical interaction ComPPI
CTSG ICE2 25348397 N/A physical interaction ComPPI
CTSG PSMG3 25348397 N/A physical interaction ComPPI
CTSG A2M 17174955 24234451 25348397 colocalization cosedimentation through density gradient ComPPI,IntAct
CTSG CYSRT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CTSG PICK1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RPS27A CTSG 25348397 N/A physical interaction ComPPI
CTSG SERPIND1 14525934 2318847 N/A experimental interaction detection HPRD
GP1BA CTSG 27898060 8400294 N/A N/A OmniPath
CTSG IGFBP3 10512690 27898060 N/A N/A OmniPath
CTSG IL33 22307629 27898060 N/A N/A OmniPath
CTSG CXCL12 11241273 27898060 N/A N/A OmniPath
ERBIN CTSG 15123239 27898060 N/A N/A OmniPath

Visualization










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