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GENE：GNAO1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GNAO1
FullNmae G protein subunit alpha o1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4389
EnsembleID ENSG00000087258
Uniprot P09471

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GNAO1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
GNAO1 GO:0003924,GO:0005515,GO:0005525,GO:0005834,GO:0005886,GO:0005886,GO:0006936,GO:0007188,GO:0007212,GO:0031683,GO:0031821,GO:0031852,GO:0046872,GO:0051430

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GNAO1 hsa:2775 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
GNAO1 hsa:2775 path:hsa04713 Circadian entrainment - Homo sapiens (human)
GNAO1 hsa:2775 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
GNAO1 hsa:2775 path:hsa04724 Glutamatergic synapse - Homo sapiens (human)
GNAO1 hsa:2775 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
GNAO1 hsa:2775 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
GNAO1 hsa:2775 path:hsa04727 GABAergic synapse - Homo sapiens (human)
GNAO1 hsa:2775 path:hsa04728 Dopaminergic synapse - Homo sapiens (human)
GNAO1 hsa:2775 path:hsa04730 Long-term depression - Homo sapiens (human)
GNAO1 hsa:2775 path:hsa04915 Estrogen signaling pathway - Homo sapiens (human)
GNAO1 hsa:2775 path:hsa04916 Melanogenesis - Homo sapiens (human)
GNAO1 hsa:2775 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
GNAO1 hsa:2775 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
GNAO1 hsa:2775 path:hsa05032 Morphine addiction - Homo sapiens (human)
GNAO1 hsa:2775 path:hsa05034 Alcoholism - Homo sapiens (human)
GNAO1 hsa:2775 path:hsa05142 Chagas disease - Homo sapiens (human)
GNAO1 hsa:2775 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
GNAO1 hsa:2775 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
GNAO1 hsa:2775 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RGS10 GNAO1 20005715 interaction type N/A PSP
RGS7 GNAO1 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
E2F4 GNAO1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 GNAO1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C GNAO1 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 GNAO1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 GNAO1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 GNAO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GNAO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GNAO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GNAO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 GNAO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GNAO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 GNAO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GNAO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF GNAO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 GNAO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 GNAO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR GNAO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 GNAO1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
OPRD1 GNAO1 25361965 interaction type N/A PTMCode2
GNAO1 OPRD1 25361965 interaction type N/A PTMCode2
GNAO1 ADRA2A 25361965 interaction type N/A PTMCode2
ADRA2A GNAO1 25361965 interaction type N/A PTMCode2
GNAO1 ADORA1 25361965 interaction type N/A PTMCode2
ADORA1 GNAO1 25361965 interaction type N/A PTMCode2
GNAO1 RIC8A 25361965 interaction type N/A PTMCode2
RIC8A GNAO1 25361965 interaction type N/A PTMCode2
GNAO1 S1PR5 25361965 interaction type N/A PTMCode2
S1PR5 GNAO1 25361965 interaction type N/A PTMCode2
GNAO1 RGS7 25361965 interaction type N/A PTMCode2
RGS7 GNAO1 25361965 interaction type N/A PTMCode2
GNAO1 RGS1 25361965 interaction type N/A PTMCode2
RGS1 GNAO1 25361965 interaction type N/A PTMCode2
GNAO1 RGS16 25361965 interaction type N/A PTMCode2
RGS16 GNAO1 25361965 interaction type N/A PTMCode2
GNAO1 RGS14 25361965 interaction type N/A PTMCode2
RGS14 GNAO1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GNAI3 GNAO1 25348397 N/A physical interaction ComPPI
HOXB5 GNAO1 25348397 N/A physical interaction ComPPI
PDE6G GNAO1 14525934 15215290 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
BAG3 GNAO1 25348397 N/A physical interaction ComPPI
PDE6H GNAO1 14525934 15215290 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
NGB GNAO1 12860983 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CD69 GNAO1 25348397 N/A physical interaction ComPPI
RGS16 GNAO1 14525934 15215290 25348397 27898060 9079700 9271201 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
OPRD1 GNAO1 11259487 14525934 25348397 8393523 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
OPRM1 GNAO1 14525934 25348397 8393523 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
KLHL3 GNAO1 11259487 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
NTRK1 GNAO1 25348397 N/A physical interaction ComPPI
RGS4 GNAO1 14525934 25348397 9660808 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
HAX1 GNAO1 25348397 N/A physical interaction ComPPI
KIFAP3 GNAO1 25348397 N/A physical interaction ComPPI
RGS19 GNAO1 14525934 25348397 8986788 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
RGS7 GNAO1 14525934 25348397 9572280 N/A experimental interaction detection,in vitro ComPPI,HPRD
RGS14 GNAO1 10926822 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CCR5 GNAO1 14525934 15251452 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
HTT GNAO1 17500595 24234451 25348397 association pull down ComPPI,IntAct
SCN8A GNAO1 10066808 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
OCRL GNAO1 24234451 25107275 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
GPSM2 GNAO1 12925752 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
TSHR GNAO1 14525934 25348397 8552586 N/A experimental interaction detection,in vivo ComPPI,HPRD
NUFIP1 GNAO1 25348397 N/A physical interaction ComPPI
RGS9 GNAO1 25348397 N/A physical interaction ComPPI
NUCB1 GNAO1 14525934 25348397 9647645 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
DUSP22 GNAO1 25348397 N/A physical interaction ComPPI
CRHR1 GNAO1 10598591 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RGS5 GNAO1 14525934 25348397 9079700 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FFAR2 GNAO1 12711604 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RIC8A GNAO1 12509430 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
CACNA1B GNAO1 11395521 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
GABBR1 GNAO1 25348397 N/A physical interaction ComPPI
RGS10 GNAO1 14525934 15215290 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
GNAI2 GNAO1 25348397 N/A physical interaction ComPPI
PTPRU GNAO1 10196137 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
DCTN2 GNAO1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
GNAI1 GNAO1 11259487 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
GRM6 GNAO1 11124982 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
GNAO1 RGS1 14525934 15215290 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
GNAO1 ADORA1 10521440 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GNAO1 S1PR5 11069896 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GNAO1 HRH4 10973974 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GNAO1 ADRA2A 11732925 14525934 25348397 7887906 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GNAO1 ADRA2C 1349607 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
GNAO1 RGS20 25348397 N/A physical interaction ComPPI
GNAO1 ARMC1 25348397 N/A physical interaction ComPPI
GNAO1 DGUOK 25348397 N/A physical interaction ComPPI
GNAO1 DNAAF2 25348397 N/A physical interaction ComPPI
GNAO1 GPR35 25348397 N/A physical interaction ComPPI
GNAO1 SLC30A4 25348397 N/A physical interaction ComPPI
GNAO1 JSRP1 25348397 N/A physical interaction ComPPI
GNAO1 CAMK2A 25348397 N/A physical interaction ComPPI
GNAO1 MED4 25348397 N/A physical interaction ComPPI
GNAO1 PCM1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
GNAO1 GNG3 25348397 N/A physical interaction ComPPI
GNAO1 GJB7 25348397 N/A physical interaction ComPPI
GNAO1 CXCR5 15251452 24234451 25348397 physical association coimmunoprecipitation ComPPI,IntAct
GNAO1 APP 23761911 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
GNAO1 GNAO1 10598591 14525934 N/A experimental interaction detection HPRD
GNAO1 ZBTB16 18262754 27898060 N/A N/A OmniPath
CNR1 GNAO1 15082510 27898060 stimulant N/A OmniPath
OPRM1 GNAO1 15082510 27898060 8393523 stimulant N/A OmniPath
DRD2 GNAO1 1445393 27898060 stimulant N/A OmniPath
PTAFR GNAO1 1311408 27898060 3013161 stimulant N/A OmniPath
GNAO1 ADCY1 17419683 27898060 8327893 inhibition N/A OmniPath
SSTR2 GNAO1 1374909 27898060 stimulant N/A OmniPath
SSTR1 GNAO1 27898060 8145728 stimulant N/A OmniPath
OPRK1 GNAO1 15082510 27898060 stimulant N/A OmniPath
OPRD1 GNAO1 11259487 15082510 27898060 8393523 stimulant N/A OmniPath
CNR2 GNAO1 15082510 27898060 stimulant N/A OmniPath
DRD3 GNAO1 15102843 27898060 stimulant N/A OmniPath
ADRA2A GNAO1 11732925 1849000 27898060 7887906 stimulant N/A OmniPath
CHRM2 GNAO1 27898060 2823384 2850835 stimulant N/A OmniPath
GABBR1 GNAO1 12917685 27898060 stimulant N/A OmniPath
OPRL1 GNAO1 15082510 27898060 stimulant N/A OmniPath

Visualization










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