GENE：PDGFC
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PDGFC |
| FullNmae | platelet derived growth factor C |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:8801 |
| EnsembleID | ENSG00000145431 |
| Uniprot | Q9NRA1 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PDGFC | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PDGFC | GO:0000139,GO:0005161,GO:0005161,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005634,GO:0005788,GO:0005829,GO:0005886,GO:0007417,GO:0008083,GO:0008284,GO:0008284,GO:0009887,GO:0009986,GO:0030335,GO:0031954,GO:0042803,GO:0043406,GO:0048008,GO:0048008,GO:0048144,GO:0048146,GO:0048565,GO:0050730,GO:0051781,GO:0051897,GO:0060348,GO:0070062,GO:0070374,GO:0071230,GO:0120162 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PDGFC | hsa:56034 | path:hsa01521 | EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human) |
| PDGFC | hsa:56034 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| PDGFC | hsa:56034 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| PDGFC | hsa:56034 | path:hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| PDGFC | hsa:56034 | path:hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| PDGFC | hsa:56034 | path:hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| PDGFC | hsa:56034 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| PDGFC | hsa:56034 | path:hsa04510 | Focal adhesion - Homo sapiens (human) |
| PDGFC | hsa:56034 | path:hsa04540 | Gap junction - Homo sapiens (human) |
| PDGFC | hsa:56034 | path:hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| PDGFC | hsa:56034 | path:hsa05215 | Prostate cancer - Homo sapiens (human) |
| PDGFC | hsa:56034 | path:hsa05218 | Melanoma - Homo sapiens (human) |
| PDGFC | hsa:56034 | path:hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PDGFC | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| YBX1 | PDGFC | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TP73 | PDGFC | 21245298 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | PDGFC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PDGFC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PDGFC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PDGFC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | PDGFC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | PDGFC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PDGFC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | PDGFC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | PDGFC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | PDGFC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | PDGFC | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PDGFC | 15247255 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP1 | PDGFC | 15247255 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | PDGFC | 15247255 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FLI1 | PDGFC | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SMAD1 | PDGFC | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BAG3 | PDGFC | 25348397 | N/A | physical interaction | ComPPI |
| SUMO1 | PDGFC | 14525934 16443219 25348397 27898060 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| PDGFRB | PDGFC | 25348397 | N/A | cross-linking study,physical interaction | ComPPI |
| PDGFRA | PDGFC | 10806482 11297552 11342471 14525934 24234451 25348397 | physical association | cross-linking study,experimental interaction detection,isothermal titration calorimetry,physical interaction,competition binding,in vitro,in vivo | ComPPI,HPRD,IntAct |
| PLAT | PDGFC | 25348397 | N/A | physical interaction | ComPPI |
| PDGFC | PLAU | 25348397 | N/A | physical interaction | ComPPI |
| PDGFC | ST14 | 25348397 | N/A | physical interaction | ComPPI |
| PDGFC | CREB3 | 25348397 | N/A | physical interaction | ComPPI |
| PDGFC | L3MBTL4 | 24234451 25348397 27705803 | association | tandem affinity purification | ComPPI,IntAct |
| PDGFC | EEA1 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| PDGFC | PDGFC | 10806482 24234451 | N/A | comigration in sds page | IntAct |
| PDGFC | PDGFRB | 11297552 27898060 | stimulant | N/A | OmniPath |
| PDGFC | PDGFRA | 10806482 11297552 11342471 15207811 20534510 27898060 | stimulant | N/A | OmniPath |