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GENE：ACTA2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ACTA2
FullNmae actin alpha 2, smooth muscle
LocusType gene with protein product
Status Approved
HGNC_id HGNC:130
EnsembleID ENSG00000107796
Uniprot P62736

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ACTA2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ACTA2 GO:0001725,GO:0005524,GO:0005604,GO:0005615,GO:0005737,GO:0005829,GO:0008217,GO:0009615,GO:0010628,GO:0014829,GO:0016787,GO:0019901,GO:0030027,GO:0030175,GO:0030485,GO:0031514,GO:0032991,GO:0044297,GO:0061870,GO:0061874,GO:0070062,GO:0070374,GO:0071560,GO:0072051,GO:0072144,GO:0090131,GO:2000491

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ACTA2 hsa:59 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
ACTA2 hsa:59 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
ACTA2 hsa:59 path:hsa04814 Motor proteins - Homo sapiens (human)
ACTA2 hsa:59 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SMAD3 ACTA2 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD4 ACTA2 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
HGF ACTA2 12649206 15059978 16212809 17145802 18633355 19631971 22763439 23402812 23667593 26192618 26366398 26819959 27474009 28475121 9242465 interaction type N/A ACSN
GLI1 ACTA2 11001584 17638910 18754008 19081070 22354771 23031257 26192618 interaction type N/A ACSN
GLI2 ACTA2 17638910 19081070 22354771 23031257 26192618 interaction type N/A ACSN
TNC ACTA2 15059978 16572188 20833777 26192618 interaction type N/A ACSN
ITGA11 ACTA2 17420280 17600088 19913614 20129924 25076207 26148229 26192618 interaction type N/A ACSN
ACTA2 TSC1 17355907 23180781 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 ACTA2 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SRF ACTA2 18337547 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 ACTA2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA ACTA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ACTA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ACTA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 ACTA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HEY1 ACTA2 18239137 trascriptional regulation,stimulation inferred by curator TFlink
HEY2 ACTA2 18239137 trascriptional regulation,stimulation inferred by curator TFlink
ELK1 ACTA2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D ACTA2 17991735 rna interference,inhibition array technology,quantitative reverse transcription pcr miRSponge
URS00005651EE ACTA2 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
LGALS3 ACTA2 25348397 N/A physical interaction ComPPI
RBM17 ACTA2 25348397 N/A physical interaction ComPPI
CFL1 ACTA2 11707283 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
UBL4A ACTA2 25348397 N/A physical interaction ComPPI
GSTP1 ACTA2 25348397 N/A physical interaction ComPPI
GABARAPL2 ACTA2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RPS26 ACTA2 25348397 N/A physical interaction ComPPI
SCGB1A1 ACTA2 25348397 N/A physical interaction ComPPI
MCM2 ACTA2 25348397 N/A physical interaction ComPPI
MAP1LC3B ACTA2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PNMA1 ACTA2 25348397 N/A physical interaction ComPPI
REG3A ACTA2 25348397 N/A physical interaction ComPPI
YIPF2 ACTA2 25348397 N/A physical interaction ComPPI
RPL10A ACTA2 25348397 N/A physical interaction ComPPI
SMURF2 ACTA2 25348397 N/A physical interaction ComPPI
ERRFI1 ACTA2 25348397 N/A physical interaction ComPPI
VAV1 ACTA2 25348397 N/A physical interaction ComPPI
ZYX ACTA2 25348397 N/A physical interaction ComPPI
ARAF ACTA2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKCD ACTA2 10628374 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
JUN ACTA2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
CREBBP ACTA2 14525934 16051665 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
EP300 ACTA2 14525934 16051665 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
COPS5 ACTA2 25348397 N/A physical interaction ComPPI
ADRA1D ACTA2 25348397 N/A physical interaction ComPPI
TTN ACTA2 24234451 25348397 9501083 physical association cosedimentation,cosedimentation in solution ComPPI,IntAct
THRB ACTA2 25348397 N/A physical interaction ComPPI
CUL3 ACTA2 25348397 N/A physical interaction ComPPI
YWHAB ACTA2 25348397 N/A physical interaction ComPPI
YWHAZ ACTA2 20618440 24234451 25348397 association tandem affinity purification ComPPI,IntAct
YBX1 ACTA2 25348397 N/A physical interaction ComPPI
BUB3 ACTA2 25348397 N/A physical interaction ComPPI
PRG2 ACTA2 25348397 N/A physical interaction ComPPI
PFN2 ACTA2 25348397 N/A physical interaction ComPPI
RPA1 ACTA2 25348397 N/A physical interaction ComPPI
DCTN1 ACTA2 25348397 N/A physical interaction ComPPI
NCF1 ACTA2 25348397 N/A physical interaction ComPPI
FSCN1 ACTA2 25348397 N/A physical interaction ComPPI
SPTAN1 ACTA2 25348397 N/A physical interaction ComPPI
KLF5 ACTA2 25348397 N/A physical interaction ComPPI
ACTN2 ACTA2 24234451 25348397 9501083 physical association cosedimentation,cosedimentation in solution ComPPI,IntAct
SELE ACTA2 25348397 N/A physical interaction ComPPI
RPA2 ACTA2 25348397 N/A physical interaction ComPPI
RPA3 ACTA2 25348397 N/A physical interaction ComPPI
TREX1 ACTA2 25348397 N/A physical interaction ComPPI
YWHAQ ACTA2 25348397 N/A physical interaction ComPPI
GEMIN2 ACTA2 25348397 N/A physical interaction ComPPI
CUL2 ACTA2 25348397 N/A physical interaction ComPPI
CUL4B ACTA2 25348397 N/A physical interaction ComPPI
CUL1 ACTA2 25348397 N/A physical interaction ComPPI
RPL7A ACTA2 25348397 N/A physical interaction ComPPI
EGFR ACTA2 25348397 N/A physical interaction ComPPI
YWHAE ACTA2 25348397 N/A physical interaction ComPPI
CCT5 ACTA2 11580270 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASQ2 ACTA2 25348397 N/A physical interaction ComPPI
URI1 ACTA2 15923622 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
OCRL ACTA2 24234451 25107275 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SNTA1 ACTA2 14525934 25348397 27898060 9512352 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
TSC1 ACTA2 17355907 24234451 25348397 physical association two hybrid ComPPI,IntAct
MAP1LC3A ACTA2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
KCNMA1 ACTA2 25348397 N/A physical interaction ComPPI
GM2A ACTA2 25348397 N/A physical interaction ComPPI
PRKN ACTA2 25348397 N/A physical interaction ComPPI
CAND1 ACTA2 25348397 N/A physical interaction ComPPI
HTR2C ACTA2 25348397 N/A physical interaction ComPPI
NFKB1 ACTA2 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
DUSP10 ACTA2 25348397 N/A physical interaction ComPPI
PECR ACTA2 25348397 N/A physical interaction ComPPI
MINK1 ACTA2 14525934 15032605 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
NPB ACTA2 25348397 N/A physical interaction ComPPI
NOP56 ACTA2 25348397 N/A physical interaction ComPPI
CGN ACTA2 25348397 N/A physical interaction ComPPI
SSH1 ACTA2 25348397 N/A physical interaction ComPPI
MYOC ACTA2 14525934 16289162 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CAP1 ACTA2 25348397 N/A physical interaction ComPPI
DUSP19 ACTA2 25348397 N/A physical interaction ComPPI
CAPNS2 ACTA2 25348397 N/A physical interaction ComPPI
RPL14 ACTA2 25348397 N/A physical interaction ComPPI
SAMD4B ACTA2 25348397 N/A physical interaction ComPPI
TES ACTA2 25348397 N/A physical interaction ComPPI
SCMH1 ACTA2 25348397 N/A physical interaction ComPPI
CAP2 ACTA2 25348397 N/A physical interaction ComPPI
MYL12B ACTA2 19328794 24234451 25348397 colocalization,association anti bait coimmunoprecipitation,confocal microscopy ComPPI,IntAct
ST8SIA4 ACTA2 25348397 N/A physical interaction ComPPI
GC ACTA2 12119014 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MYH9 ACTA2 25348397 N/A physical interaction ComPPI
DNASE1 ACTA2 11707283 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ALOX12 ACTA2 25348397 N/A physical interaction ComPPI
CHRM4 ACTA2 25348397 N/A physical interaction ComPPI
DHCR24 ACTA2 25348397 N/A physical interaction ComPPI
MYO1C ACTA2 25348397 N/A physical interaction ComPPI
SHBG ACTA2 14525934 15862967 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ACTA2 MYL1 11707283 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ACTA2 PCYT1B 11580270 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ACTA2 CCT4 11580270 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ACTA2 LRRK2 25348397 N/A physical interaction ComPPI
ACTA2 MYH11 25348397 N/A physical interaction ComPPI
ACTA2 RPL18 25348397 N/A physical interaction ComPPI
ACTA2 RPS23 25348397 N/A physical interaction ComPPI
ACTA2 RPL17 25348397 N/A physical interaction ComPPI
ACTA2 RPS16 25348397 N/A physical interaction ComPPI
ACTA2 RPS4X 25348397 N/A physical interaction ComPPI
ACTA2 MYH10 25348397 N/A physical interaction ComPPI
ACTA2 ACTC1 25348397 N/A physical interaction ComPPI
ACTA2 TPM1 25348397 N/A physical interaction ComPPI
ACTA2 MRPL47 25348397 N/A physical interaction ComPPI
ACTA2 AARS1 25348397 N/A physical interaction ComPPI
ACTA2 UBAP1 25348397 N/A physical interaction ComPPI
ACTA2 MRPS2 25348397 N/A physical interaction ComPPI
ACTA2 MRPS7 25348397 N/A physical interaction ComPPI
ACTA2 CNN2 25348397 N/A physical interaction ComPPI
ACTA2 NCF1B 25348397 N/A physical interaction ComPPI
ACTA2 TP53 25348397 N/A physical interaction ComPPI
ACTA2 ZMAT3 25348397 N/A physical interaction ComPPI
ACTA2 TFDP3 25348397 N/A physical interaction ComPPI
ACTA2 ICE2 25348397 N/A physical interaction ComPPI
ACTA2 LRRTM2 25348397 N/A physical interaction ComPPI
ACTA2 MAP1LC3C 25348397 N/A physical interaction ComPPI
ACTA2 RBM18 25348397 N/A physical interaction ComPPI
ACTA2 PPP1R1A 25348397 N/A physical interaction ComPPI
ACTA2 UBE3A 25348397 N/A physical interaction ComPPI
ACTA2 ERBB3 25348397 N/A physical interaction ComPPI
ACTA2 PHACTR2 25348397 N/A physical interaction ComPPI
ACTA2 TMOD3 25348397 N/A physical interaction ComPPI
ACTA2 BCL7C 25348397 N/A physical interaction ComPPI
ACTA2 TWF2 25348397 N/A physical interaction ComPPI
ACTA2 DBN1 25348397 N/A physical interaction ComPPI
ACTA2 ZMAT5 25348397 N/A physical interaction ComPPI
ACTA2 RNASE3 25348397 N/A physical interaction ComPPI
ACTA2 CDK10 25348397 N/A physical interaction ComPPI
ACTA2 ZNF433 25348397 N/A physical interaction ComPPI
ACTA2 IL36A 25348397 N/A physical interaction ComPPI
ACTA2 SPATA22 25348397 N/A physical interaction ComPPI
ACTA2 IL17RE 25348397 N/A physical interaction ComPPI
ACTA2 ACTBL2 25348397 N/A physical interaction ComPPI
ACTA2 NEXN 25348397 N/A physical interaction ComPPI
ACTA2 TCP11L2 25348397 N/A physical interaction ComPPI
ACTA2 TMEM220 25348397 N/A physical interaction ComPPI
ACTA2 LIM2 25348397 N/A physical interaction ComPPI
ACTA2 PLEKHG6 25348397 N/A physical interaction ComPPI
ACTA2 AFM 25348397 N/A physical interaction ComPPI
ACTA2 C9ORF43 25348397 N/A physical interaction ComPPI
ACTA2 RNF217 25348397 N/A physical interaction ComPPI
ACTA2 CENPC 25348397 N/A physical interaction ComPPI
ACTA2 ADAM21 25348397 N/A physical interaction ComPPI
ACTA2 MAS1 25348397 N/A physical interaction ComPPI
ACTA2 CPLX4 25348397 N/A physical interaction ComPPI
ACTA2 MUC1 25348397 N/A physical interaction ComPPI
ACTA2 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ACTA2 USE1 19369418 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
RPS15A ACTA2 25348397 N/A physical interaction ComPPI
TRIM9 ACTA2 25348397 N/A physical interaction ComPPI
UBXN4 ACTA2 25348397 N/A physical interaction ComPPI
THAP11 ACTA2 25348397 N/A physical interaction ComPPI
TMSB4X ACTA2 11812134 14525934 N/A experimental interaction detection HPRD
TP53 ACTA2 17409411 27898060 stimulant N/A OmniPath
ACTA2 TSC1 17355907 27898060 N/A N/A OmniPath
TSC1 ACTA2 17355907 27898060 N/A N/A OmniPath

Visualization










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