Gene Information gene info

  1. Home

GENE：APH1A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol APH1A
FullNmae aph-1 homolog A, gamma-secretase subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:29509
EnsembleID ENSG00000117362
Uniprot Q96BI3

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
APH1A immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
APH1A GO:0000139,GO:0001656,GO:0005515,GO:0005769,GO:0005783,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0005886,GO:0005886,GO:0006509,GO:0007219,GO:0007220,GO:0007220,GO:0007220,GO:0007220,GO:0007220,GO:0008021,GO:0010008,GO:0010950,GO:0010950,GO:0016020,GO:0016020,GO:0016485,GO:0016485,GO:0016485,GO:0016485,GO:0019899,GO:0030674,GO:0030674,GO:0031293,GO:0031293,GO:0031293,GO:0032580,GO:0034205,GO:0034205,GO:0034205,GO:0042734,GO:0042982,GO:0042987,GO:0042987,GO:0042987,GO:0042987,GO:0042987,GO:0043085,GO:0061133,GO:0061133,GO:0070765,GO:0070765,GO:0070765,GO:0070765

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
APH1A hsa:51107 path:hsa04330 Notch signaling pathway - Homo sapiens (human)
APH1A hsa:51107 path:hsa05010 Alzheimer disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APH1A APH1B 16252010 16630834 26192618 association N/A ACSN
APH1A NGF 16252010 16630834 26192618 interaction type N/A ACSN
APH1A NGFR 16252010 16630834 26192618 interaction type N/A ACSN
APH1A TRAF6 16252010 16630834 26192618 interaction type N/A ACSN
CXCR1 APH1A 23180781 24914212 physical association anti tag coimmunoprecipitation,bioluminescence resonance energy transfer InnateDB
NCSTN APH1A 12297508 12471034 12857757 14572442 15189355 21071413 23331499 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
APH1A PSEN1 20005715 interaction type N/A PSP
APH1A PSEN2 20005715 interaction type N/A PSP,SignaLink
APH1A PSENEN 14572442 20005715 21071413 interaction type N/A PSP,SignaLink
APH1A PSEN1 12471034 14572442 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 APH1A 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YY1 APH1A 21443683 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004F4657 APH1A 21351259 rna interference,inhibition array technology,experimental interaction detection miRSponge
URS00004F4657 APH1A 21351259 25416803 mrna cleavage,inhibition array technology,experimental interaction detection TarBase
URS000037D7E5 APH1A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003883FE APH1A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075A9CF APH1A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000040FA88 APH1A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000015A0D9 APH1A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000047A8F APH1A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000214763 APH1A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 APH1A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002578DA APH1A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003804D8 APH1A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002E728C APH1A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002B0B46 APH1A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000076E54 APH1A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000005E58C APH1A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 APH1A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 APH1A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C APH1A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 APH1A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 APH1A 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001919B0 APH1A 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TMED10 APH1A 25361965 interaction type N/A PTMCode2
APH1A TMED10 25361965 interaction type N/A PTMCode2
NCSTN APH1A 25361965 interaction type N/A PTMCode2
APH1A NCSTN 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
BHLHE40 APH1A 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SMAGP APH1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMEM218 APH1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ATF4 APH1A 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SCAND1 APH1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GLP1R APH1A 25348397 N/A physical interaction ComPPI
FIS1 APH1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SERP1 APH1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TLE1 APH1A 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
APOD APH1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KLF11 APH1A 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PSEN2 APH1A 25348397 N/A physical interaction,in vitro,in vivo ComPPI
NCSTN APH1A 12297508 18201567 19376115 24234451 25348397 26280335 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,electron tomography,in vitro,in vivo ComPPI,IntAct
CREB3 APH1A 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HIVEP1 APH1A 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MPP1 APH1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ELAVL1 APH1A 25348397 N/A physical interaction ComPPI
APH1A PSENEN 19376115 24234451 25348397 26280335 association,physical association anti tag coimmunoprecipitation,physical interaction,electron tomography,in vivo ComPPI,IntAct
APH1A TMED10 25348397 N/A in vivo ComPPI
APH1A PSEN1 24234451 25348397 26280335 physical association physical interaction,electron tomography,in vitro,in vivo ComPPI,IntAct
APH1A RBFOX2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
APH1A HES1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
APH1A THPO 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
APH1A GPATCH8 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
APH1A ERLIN2 25348397 N/A physical interaction ComPPI
APH1A MOV10 25348397 N/A physical interaction ComPPI
APH1A NXF1 25348397 N/A physical interaction ComPPI
APH1A IGFBP5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APH1A SLC38A7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APH1A MFSD6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APH1A FXYD6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APH1A ASGR1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APH1A SLC39A9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APH1A MRAP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TMEM140 APH1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
APH1A DRD2 24234451 28298427 physical association ubiquitin reconstruction IntAct
GPR35 APH1A 24234451 28298427 physical association ubiquitin reconstruction IntAct
APH1A APP 12011466 27898060 N/A N/A OmniPath
APH1A JAG2 12551931 27898060 N/A N/A OmniPath
APH1A PSEN1 12297508 12471034 12522139 14572442 15146195 15474363 17911105 27898060 stimulant N/A OmniPath
NCSTN APH1A 12297508 12471034 12857757 14572442 15189355 15257293 15474363 17911105 18201567 19376115 27898060 stimulant N/A OmniPath
APH1A NCSTN 12297508 12471034 12857757 14572442 15257293 15474363 17911105 18201567 19376115 27898060 stimulant N/A OmniPath
APH1A PSENEN 12522139 12740439 14572442 15322109 15474363 17911105 19376115 22074918 27898060 stimulant N/A OmniPath
APH1A PSEN2 12297508 12471034 15474363 27898060 stimulant N/A OmniPath
CXCR1 APH1A 24914212 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008C37AD APH1A 27087310 direct interaction,inhibition N/A NPInter

Visualization










  Return