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GENE：APLP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol APLP2
FullNmae amyloid beta precursor like protein 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:598
EnsembleID ENSG00000084234
Uniprot Q06481

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
APLP2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
APLP2 GO:0003677,GO:0004867,GO:0005515,GO:0005634,GO:0005788,GO:0005886,GO:0007186,GO:0007409,GO:0007417,GO:0008201,GO:0016020,GO:0016020,GO:0031092,GO:0042802,GO:0046914,GO:0070062

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR APLP2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 APLP2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 APLP2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 APLP2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 APLP2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 APLP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA APLP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF APLP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 APLP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 APLP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 APLP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS APLP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A APLP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF APLP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 APLP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 APLP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000134ADC APLP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000600E6 APLP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000DDD35 APLP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000239117 APLP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000045E0EC APLP2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS0000284586 APLP2 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 APLP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F APLP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 APLP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 APLP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002E0524 APLP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003BBF48 APLP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000521626 APLP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000000C73C APLP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001270D3 APLP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000BF7F9 APLP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000AD002 APLP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005DEC41 APLP2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075994C APLP2 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 APLP2 22135298 phosphorylation N/A PhosphoSite
MAPK9 APLP2 22135298 phosphorylation N/A PhosphoSite
PRKCA APLP2 22135298 phosphorylation N/A PhosphoSite
MAPK8 APLP2 22135298 phosphorylation N/A PhosphoSite
MAPK10 APLP2 22135298 phosphorylation N/A PhosphoSite
APLP2 APBB1 25361965 interaction type N/A PTMCode2
APBB1 APLP2 25361965 interaction type N/A PTMCode2
APLP2 DAB1 25361965 interaction type N/A PTMCode2
DAB1 APLP2 25361965 interaction type N/A PTMCode2
MAPK8IP1 APLP2 25361965 interaction type N/A PTMCode2
APLP2 MAPK8IP1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ZNF512B APLP2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
JUNB APLP2 20195357 24234451 25348397 physical association display technology,physical interaction ComPPI,IntAct
DAB2 APLP2 25348397 N/A physical interaction ComPPI
VAV1 APLP2 25348397 N/A physical interaction ComPPI
MAPK8 APLP2 25348397 N/A physical interaction ComPPI
PRKCA APLP2 14525934 25348397 9109675 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
JUN APLP2 20195357 20936779 24234451 25348397 physical association display technology,physical interaction,two hybrid pooling approach ComPPI,IntAct
HGS APLP2 25348397 N/A physical interaction ComPPI
PIK3CA APLP2 10490823 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
DAB1 APLP2 10460257 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PRNP APLP2 14525934 15146195 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PTPN1 APLP2 25348397 N/A physical interaction ComPPI
PTPN2 APLP2 25348397 N/A physical interaction ComPPI
BAG6 APLP2 25348397 N/A physical interaction ComPPI
APBB1 APLP2 14525934 24234451 25348397 8894693 9461550 physical association two hybrid,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
SFN APLP2 25348397 N/A physical interaction ComPPI
MED12 APLP2 21293490 24234451 25348397 N/A pull down ComPPI,IntAct
HDAC5 APLP2 25348397 N/A physical interaction ComPPI
NFKB1 APLP2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
TRIM25 APLP2 25348397 N/A physical interaction ComPPI
HLA-A APLP2 14525934 19184004 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
FCGRT APLP2 25348397 N/A physical interaction ComPPI
DEDD APLP2 20195357 24234451 25348397 physical association display technology,physical interaction,tandem affinity purification ComPPI,IntAct
ELAVL1 APLP2 25348397 N/A physical interaction ComPPI
BRCA1 APLP2 25348397 N/A physical interaction ComPPI
AKT1 APLP2 10490823 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MED4 APLP2 21293490 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
APLP2 APBB2 14525934 24234451 25348397 8855266 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
APLP2 APBB3 10081969 14525934 24234451 25348397 9461550 physical association two hybrid,experimental interaction detection,physical interaction ComPPI,HPRD,IntAct
APLP2 RYK 25348397 N/A physical interaction ComPPI
APLP2 KAT5 25348397 N/A physical interaction ComPPI
APLP2 VKORC1 25348397 N/A physical interaction ComPPI
APLP2 RPL26 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
APLP2 ETS1 20195357 24234451 25348397 physical association display technology,physical interaction ComPPI,IntAct
APLP2 KLK2 25348397 N/A physical interaction ComPPI
APLP2 APBA3 24234451 25348397 26948053 physical association two hybrid,physical interaction ComPPI,IntAct
APLP2 DKKL1 25348397 N/A physical interaction ComPPI
APLP2 NKTR 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
APLP2 APP 25348397 N/A anti tag coimmunoprecipitation ComPPI
APLP2 APLP1 16193067 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation ComPPI,IntAct,OmniPath
APLP2 SPON1 14983046 24234451 25348397 physical association pull down ComPPI,IntAct
APLP2 APLP2 14525934 16193067 24234451 8894693 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection HPRD,IntAct
CDK1 APLP2 14525934 9109675 N/A experimental interaction detection HPRD
H1-2 APLP2 24234451 30021884 physical association cross-linking study IntAct
PRKCA APLP2 27898060 9109675 N/A N/A OmniPath
MAPK10 APLP2 27898060 9109675 N/A N/A OmniPath
CDK1 APLP2 27898060 9109675 stimulant N/A OmniPath
MAPK8 APLP2 14970211 27898060 9109675 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008B26B9 APLP2 27087310 direct interaction,inhibition N/A NPInter

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