Gene Information gene info

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GENE：DEF6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DEF6
FullNmae DEF6 guanine nucleotide exchange factor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2760
EnsembleID ENSG00000023892
Uniprot Q9H4E7

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DEF6 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DEF6 GO:0005085,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005829,GO:0005856,GO:0005886,GO:0016020,GO:0030175,GO:0048471,GO:0051056,GO:0098876

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IRF4 DEF6 12651066 23180781 physical association two hybrid InnateDB
APP DEF6 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 DEF6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 DEF6 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 DEF6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DEF6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 DEF6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DEF6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DEF6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 DEF6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 DEF6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 DEF6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003808EC DEF6 22100165 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ITK DEF6 22135298 phosphorylation N/A PhosphoSite
RAC2 DEF6 25361965 interaction type N/A PTMCode2
DEF6 RAC2 25361965 interaction type N/A PTMCode2
ZAP70 DEF6 25361965 interaction type N/A PTMCode2
DEF6 ZAP70 25361965 interaction type N/A PTMCode2
DEF6 LCK 25361965 interaction type N/A PTMCode2
LCK DEF6 25361965 interaction type N/A PTMCode2
DEF6 RAC1 25361965 interaction type N/A PTMCode2
RAC1 DEF6 25361965 interaction type N/A PTMCode2
CDC42 DEF6 25361965 interaction type N/A PTMCode2
DEF6 CDC42 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SLU7 DEF6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DEF6 RHOA 14525934 15023524 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DEF6 RAC1 14525934 15023524 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DEF6 RAC2 14525934 15023524 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DEF6 CDC42 14525934 15023524 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DEF6 BEGAIN 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
DEF6 ZAP70 12648457 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
DEF6 LCK 12923183 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
DEF6 APP 25348397 N/A physical interaction ComPPI
DEF6 PLSCR1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
DEF6 PTK2 25348397 N/A physical interaction ComPPI
DEF6 TCF4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
DEF6 CDC42EP1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
DEF6 EIF4ENIF1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
DEF6 PBXIP1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
DEF6 HOMEZ 25348397 N/A physical interaction ComPPI
DEF6 DCXR 25348397 N/A physical interaction ComPPI
DEF6 CHAMP1 25348397 N/A physical interaction ComPPI
DEF6 ADD2 25348397 N/A physical interaction ComPPI
DEF6 ARHGAP42 25348397 N/A physical interaction ComPPI
DEF6 RBM45 25348397 N/A physical interaction ComPPI
DEF6 MYCBP2 25348397 N/A physical interaction ComPPI
DEF6 SMARCA1 25348397 N/A physical interaction ComPPI
DEF6 BABAM1 25348397 N/A physical interaction ComPPI
DEF6 BRCC3 25348397 N/A physical interaction ComPPI
DEF6 ABRAXAS2 25348397 N/A physical interaction ComPPI
DEF6 BABAM2 25348397 N/A physical interaction ComPPI
DEF6 ANKS1A 25348397 N/A physical interaction ComPPI
DEF6 NFKB2 25348397 N/A physical interaction ComPPI
DEF6 KBTBD6 25348397 N/A physical interaction ComPPI
DEF6 PRKCQ 25348397 N/A physical interaction ComPPI
DEF6 GRID1 25348397 N/A physical interaction ComPPI
DEF6 C1ORF52 25348397 N/A physical interaction ComPPI
DEF6 DCAF16 25348397 N/A physical interaction ComPPI
DEF6 TNRC6C 25348397 N/A physical interaction ComPPI
DEF6 RCC2 25348397 N/A physical interaction ComPPI
DEF6 PSMA1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DEF6 ZNF688 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DEF6 RASAL3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DEF6 SAP18 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DEF6 SDCBP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DEF6 KRT31 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DEF6 INCA1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DEF6 CCDC88B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DEF6 TEPSIN 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DEF6 INTS2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DEF6 KIAA1328 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DEF6 GOLGA6A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DEF6 GOLGA6L9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IRF4 DEF6 12651066 27898060 N/A N/A OmniPath
LCK DEF6 12923183 18976935 27898060 stimulant N/A OmniPath
DEF6 CDC42 15023524 18976935 27898060 stimulant N/A OmniPath
DEF6 RAP1B 26483383 27898060 stimulant N/A OmniPath
DEF6 RAP1A 26483383 27898060 stimulant N/A OmniPath
ITK DEF6 22829599 27898060 N/A N/A OmniPath

Visualization










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