Gene Information gene info

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GENE：PYCR1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PYCR1
FullNmae pyrroline-5-carboxylate reductase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9721
EnsembleID ENSG00000183010
Uniprot P32322

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PYCR1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PYCR1 GO:0004735,GO:0004735,GO:0005515,GO:0005739,GO:0005759,GO:0006561,GO:0034599,GO:0042802,GO:0051881,GO:0055129,GO:0055129,GO:1903377

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PYCR1 hsa:5831 path:hsa00330 Arginine and proline metabolism - Homo sapiens (human)
PYCR1 hsa:5831 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PYCR1 hsa:5831 path:hsa01230 Biosynthesis of amino acids - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SUZ12 PYCR1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
RNF2 PYCR1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
BMI1 PYCR1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 PYCR1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 PYCR1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA PYCR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PYCR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PYCR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PYCR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC PYCR1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 PYCR1 21566225 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS000041FA2C PYCR1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000000B1C9 PYCR1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004CCDA3 PYCR1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000048F59D PYCR1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000279B6F PYCR1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003804D8 PYCR1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000014F13C PYCR1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000017CCCB PYCR1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000D0BB4 PYCR1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000007F792 PYCR1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000472A9B PYCR1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003E5ECC PYCR1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000015A0D9 PYCR1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005E1A16 PYCR1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001DA458 PYCR1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK2 PYCR1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
NUDT21 PYCR1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BAG3 PYCR1 25348397 N/A physical interaction ComPPI
LCA5 PYCR1 24234451 25348397 26638075 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FASTKD3 PYCR1 20869947 24234451 25348397 association tandem affinity purification ComPPI,IntAct
BMI1 PYCR1 25348397 N/A physical interaction ComPPI
KEAP1 PYCR1 25348397 N/A physical interaction ComPPI
HNRNPH2 PYCR1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDK2AP2 PYCR1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DAB2 PYCR1 25348397 N/A physical interaction ComPPI
JUN PYCR1 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
CDC16 PYCR1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CUL3 PYCR1 25348397 N/A physical interaction ComPPI
DAP3 PYCR1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NTRK1 PYCR1 25348397 N/A physical interaction ComPPI
PDHA1 PYCR1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
DUSP14 PYCR1 25348397 N/A physical interaction ComPPI
RNF2 PYCR1 25348397 N/A physical interaction ComPPI
MDC1 PYCR1 25348397 N/A physical interaction ComPPI
VCAM1 PYCR1 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
ITGA4 PYCR1 25348397 N/A physical interaction ComPPI
PDK1 PYCR1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
BNIPL PYCR1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HNRNPD PYCR1 25348397 N/A physical interaction ComPPI
PARK7 PYCR1 23743200 24234451 25348397 27898060 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,fluorescence microscopy ComPPI,IntAct,OmniPath
AURKAIP1 PYCR1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CEP162 PYCR1 24234451 25348397 26638075 association anti tag coimmunoprecipitation,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
SUZ12 PYCR1 25348397 N/A physical interaction ComPPI
HSPD1 PYCR1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
FUS PYCR1 25348397 N/A physical interaction ComPPI
AIFM1 PYCR1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 PYCR1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CCDC47 PYCR1 25348397 N/A physical interaction ComPPI
MGST3 PYCR1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NUDT5 PYCR1 25348397 N/A physical interaction ComPPI
PYCR2 PYCR1 25348397 N/A physical interaction ComPPI
ARMC6 PYCR1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SFXN1 PYCR1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
G3BP1 PYCR1 25348397 N/A physical interaction ComPPI
PYCR3 PYCR1 25348397 N/A physical interaction ComPPI
LRRK2 PYCR1 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
KLHDC10 PYCR1 25348397 N/A physical interaction ComPPI
TRMT61B PYCR1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SIRT4 PYCR1 24234451 25348397 25525879 association anti tag coimmunoprecipitation ComPPI,IntAct
PYCR1 SOAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PYCR1 COX14 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PYCR1 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PYCR1 COQ3 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
PYCR1 PYCR1 16730026 24234451 2722838 physical association molecular sieving,x-ray crystallography IntAct
PYCR1 ASCC3 24234451 30021884 physical association cross-linking study IntAct

Visualization










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