GENE：SLC4A4
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SLC4A4 |
| FullNmae | solute carrier family 4 member 4 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11030 |
| EnsembleID | ENSG00000080493 |
| Uniprot | Q9Y6R1 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SLC4A4 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SLC4A4 | GO:0005452,GO:0005515,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0006814,GO:0008509,GO:0008510,GO:0008510,GO:0008510,GO:0008510,GO:0009986,GO:0015293,GO:0015698,GO:0015701,GO:0015701,GO:0015701,GO:0015701,GO:0016020,GO:0016323,GO:0016323,GO:0016323,GO:0035725,GO:0036376,GO:0042391,GO:0042391,GO:0042802,GO:0045821,GO:0045821,GO:0051453,GO:0051453,GO:0051453,GO:0051453,GO:0051453,GO:0055085,GO:0055085,GO:0070062,GO:0098656,GO:0150104 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SLC4A4 | hsa:8671 | path:hsa04964 | Proximal tubule bicarbonate reclamation - Homo sapiens (human) |
| SLC4A4 | hsa:8671 | path:hsa04972 | Pancreatic secretion - Homo sapiens (human) |
| SLC4A4 | hsa:8671 | path:hsa04976 | Bile secretion - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SLC4A4 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | SLC4A4 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| HIF1A | SLC4A4 | 18971253 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| FOXP3 | SLC4A4 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | SLC4A4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SLC4A4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SLC4A4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | SLC4A4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SLC4A4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | SLC4A4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | SLC4A4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | SLC4A4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | SLC4A4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | SLC4A4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00003E6EFA | SLC4A4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004CCA62 | SLC4A4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000183BED | SLC4A4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CC864 | SLC4A4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AD2AA | SLC4A4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000011DF | SLC4A4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKACA | SLC4A4 | 25348397 | N/A | in vitro | ComPPI |
| CA2 | SLC4A4 | 25348397 | N/A | in vitro | ComPPI |
| SREBF2 | SLC4A4 | 20936779 24234451 25348397 | physical association | physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach | ComPPI,IntAct |
| SLC4A4 | SLC4A7 | 10600945 25348397 27898060 | N/A | in vivo | ComPPI,OmniPath |
| SLC4A4 | CA4 | 14567693 15563508 24234451 25348397 27898060 | colocalization,physical association | far western blotting,in vitro,in vivo,confocal microscopy | ComPPI,IntAct,OmniPath |
| SLC4A4 | SCRIB | 24234451 24550280 25348397 | physical association | phage display | ComPPI,IntAct |
| ATP2A2 | SLC4A4 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| PRKACA | SLC4A4 | 11744745 12411514 12730338 27898060 | N/A | N/A | OmniPath |
| LYN | SLC4A4 | 11744745 27898060 | N/A | N/A | OmniPath |
| STK39 | SLC4A4 | 23431199 27898060 | N/A | N/A | OmniPath |