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GENE：SPEN

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SPEN
FullNmae spen family transcriptional repressor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17575
EnsembleID ENSG00000065526
Uniprot Q96T58

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SPEN immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SPEN GO:0000122,GO:0003677,GO:0003714,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005654,GO:0006357,GO:0007219,GO:0017053,GO:0045892,GO:0050769,GO:0061629,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SPEN hsa:23013 path:hsa04330 Notch signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PAK1 SPEN 15824732 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,two hybrid,pull down,protein kinase assay InnateDB
SPEN CEBPD 21072181 23180781 physical association anti tag coimmunoprecipitation InnateDB
PLCG1 SPEN 17474147 23180781 physical association peptide array InnateDB
BMI1 SPEN 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR SPEN 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 SPEN 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 SPEN 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 SPEN 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 SPEN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SPEN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SPEN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SPEN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SPEN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 SPEN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SPEN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SPEN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SPEN 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000016C318 SPEN 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000070B1D SPEN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000183BED SPEN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004E008F SPEN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 SPEN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 SPEN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BE495 SPEN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D SPEN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001597DC SPEN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005FDE70 SPEN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000600E6 SPEN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD SPEN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 SPEN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000035CC3E SPEN 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000A057E SPEN 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000160683 SPEN 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000246356 SPEN 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000157F5 SPEN 24297251 direct interaction,mrna cleavage,inhibition experimental interaction detection StarBase

Source Target Pmid Interactiontype Methods Database
CHEK1 SPEN 22135298 phosphorylation N/A PhosphoSite
PAK1 SPEN 22135298 phosphorylation N/A PhosphoSite
MSX2 SPEN 25361965 interaction type N/A PTMCode2
SPEN MSX2 25361965 interaction type N/A PTMCode2
SRA1 SPEN 25361965 interaction type N/A PTMCode2
SPEN SRA1 25361965 interaction type N/A PTMCode2
RBPJ SPEN 25361965 interaction type N/A PTMCode2
SPEN RBPJ 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CDC5L SPEN 20467437 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ATXN1 SPEN 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
BMI1 SPEN 25348397 N/A physical interaction ComPPI
DPPA4 SPEN 25348397 N/A physical interaction ComPPI
CRK SPEN 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
UBE2E2 SPEN 25348397 N/A physical interaction ComPPI
SERTAD1 SPEN 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PIK3R1 SPEN 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
NCK1 SPEN 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
GRB2 SPEN 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
CTBP1 SPEN 25348397 N/A physical interaction ComPPI
TTN SPEN 25348397 N/A physical interaction ComPPI
NCOR2 SPEN 24234451 24268649 25348397 N/A two hybrid,isothermal titration calorimetry,nuclear magnetic resonance,surface plasmon resonance,physical interaction,in vitro,in vivo,surface plasmon resonance array ComPPI,IntAct
NCOR1 SPEN 11331609 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
SCYL2 SPEN 25348397 N/A physical interaction ComPPI
PIR SPEN 25348397 N/A physical interaction ComPPI
CLK1 SPEN 25348397 N/A physical interaction ComPPI
SOX9 SPEN 11331609 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PPARD SPEN 11867749 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RBBP4 SPEN 11331609 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RBBP8 SPEN 25348397 N/A physical interaction ComPPI
SOX2 SPEN 25348397 N/A physical interaction ComPPI
EGFR SPEN 25348397 N/A physical interaction ComPPI
HDAC2 SPEN 25348397 N/A in vitro,in vivo ComPPI
MED23 SPEN 25348397 N/A physical interaction ComPPI
EED SPEN 25348397 N/A physical interaction ComPPI
CUL7 SPEN 25348397 N/A physical interaction ComPPI
DLX5 SPEN 10451362 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NR3C1 SPEN 25348397 N/A physical interaction ComPPI
BCLAF1 SPEN 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SPEN MTA2 11331609 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SPEN MBD3 25348397 N/A in vivo ComPPI
SPEN MSX2 10451362 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SPEN UBE2L6 14525934 16583136 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
SPEN RBPJ 12374742 14525934 21102556 24234451 25348397 25609649 association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,tandem affinity purification,two hybrid ComPPI,HPRD,IntAct
SPEN HDAC1 11331609 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
SPEN SRA1 25348397 N/A physical interaction ComPPI
SPEN RUNX1T1 25348397 N/A physical interaction ComPPI
SPEN RUNX1 25348397 N/A physical interaction ComPPI
SPEN SIRT7 25348397 N/A physical interaction ComPPI
SPEN NOTCH2 25348397 N/A physical interaction ComPPI
SPEN BPGM 25348397 N/A physical interaction ComPPI
SPEN PRDX3 25348397 N/A physical interaction ComPPI
SPEN PCBP3 25348397 N/A physical interaction ComPPI
SPEN NUP54 25348397 N/A physical interaction ComPPI
SPEN OBSL1 25348397 N/A physical interaction ComPPI
SPEN CCNC 25348397 N/A physical interaction ComPPI
SPEN WRAP73 25348397 N/A physical interaction ComPPI
SPEN SRPK2 25348397 N/A physical interaction ComPPI
SPEN DYNLT1 25348397 N/A physical interaction ComPPI
SPEN FERMT3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SPEN USP37 25348397 N/A physical interaction ComPPI
SPEN TRIML2 25348397 N/A physical interaction ComPPI
SPEN CAMKV 25348397 N/A physical interaction ComPPI
SPEN PIP4K2A 25348397 N/A physical interaction ComPPI
SPEN BCL6 16147992 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SPEN PLCG1 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
SPEN TCTE1 24234451 25348397 26638075 association proximity-dependent biotin identification ComPPI,IntAct
SPEN RRP1B 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
RIDA SPEN 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SGG SPEN 25348397 N/A anti tag coimmunoprecipitation ComPPI
SPEN RARA 11331609 14525934 N/A experimental interaction detection HPRD
MKI67 SPEN 24234451 26949251 association anti tag coimmunoprecipitation IntAct
HMGA1 SPEN 24234451 30021884 physical association cross-linking study IntAct
RPL10A SPEN 24234451 30021884 physical association cross-linking study IntAct
RPS6KA5 SPEN 15824732 27898060 N/A N/A OmniPath
NCOR2 SPEN 11331609 15604093 24268649 27898060 stimulant N/A OmniPath
RBBP8 SPEN 16287852 27898060 inhibition N/A OmniPath
SPEN RBPJ 12374742 12594956 18332109 21102556 25609649 26186194 27898060 inhibition N/A OmniPath
PAK1 SPEN 15824732 27898060 N/A N/A OmniPath
MSX2 SPEN 10451362 19835636 27898060 stimulant N/A OmniPath

Visualization










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