Gene Information gene info

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GENE：TEC

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TEC
FullNmae tec protein tyrosine kinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11719
EnsembleID ENSG00000135605
Uniprot P42680

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TEC immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TEC GO:0002250,GO:0004715,GO:0004715,GO:0005515,GO:0005524,GO:0005543,GO:0005829,GO:0005856,GO:0005886,GO:0005886,GO:0006468,GO:0006468,GO:0007229,GO:0007229,GO:0010543,GO:0010543,GO:0035556,GO:0042246,GO:0043621,GO:0046872,GO:0050852,GO:0050853,GO:0050853

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TEC hsa:7006 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
TEC hsa:7006 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TEC GRAP 11406363 15214048 26192618 interaction type N/A ACSN
TEC GRB2 11406363 15214048 26192618 interaction type N/A ACSN
TEC LAT 11406363 15214048 26192618 interaction type N/A ACSN
TEC PLCG1 11406363 15214048 26192618 interaction type N/A ACSN
PRKCQ TEC 10652356 11687500 11747822 12670391 15214048 15536066 15802604 16606694 17544292 17548359 17680028 18784374 18802401 19109239 19122654 19201850 23077238 23433459 23474202 23886063 25960930 26192618 interaction type N/A ACSN
IKBKG TEC 20098747 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
DOK1 TEC 20005715 interaction type N/A PSP
PIK3R1 TEC 20005715 interaction type N/A PSP
SHC1 TEC 20005715 interaction type N/A PSP
SOCS1 TEC 20005715 interaction type N/A PSP
DOK1 TEC 11071635 11071635 11825908 20005715 20005715 21071413 N/A N/A SignaLink
SOCS1 TEC 18988627 20005715 20005715 21071413 9341160 9341160 9341160 N/A N/A SignaLink
PIK3R1 TEC 18988627 20005715 20005715 9178903 N/A N/A SignaLink
SHC1 TEC 11825908 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR TEC 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 TEC 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 TEC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TEC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 TEC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 TEC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TEC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 TEC 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
TEC BTK 22135298 phosphorylation N/A PhosphoSite
TEC ITK 22135298 phosphorylation N/A PhosphoSite
TEC PTPN18 22135298 phosphorylation N/A PhosphoSite
TEC BMX 22135298 phosphorylation N/A PhosphoSite
TEC TEC 22135298 phosphorylation N/A PhosphoSite
ITK TEC 22135298 phosphorylation N/A PhosphoSite
BTK TEC 22135298 phosphorylation N/A PhosphoSite
TEC JAK2 25361965 interaction type N/A PTMCode2
JAK2 TEC 25361965 interaction type N/A PTMCode2
PLCG2 TEC 25361965 interaction type N/A PTMCode2
TEC PLCG2 25361965 interaction type N/A PTMCode2
KIT TEC 25361965 interaction type N/A PTMCode2
TEC KIT 25361965 interaction type N/A PTMCode2
PTPN21 TEC 25361965 interaction type N/A PTMCode2
TEC PTPN21 25361965 interaction type N/A PTMCode2
DOK1 TEC 25361965 interaction type N/A PTMCode2
TEC DOK1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIK3R2 TEC 25348397 N/A physical interaction ComPPI
WAS TEC 14525934 24234451 25348397 8892607 physical association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
STAP1 TEC 10518561 11716489 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ERBB2 TEC 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
PTPN18 TEC 14525934 14679216 15588985 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
VAV1 TEC 14525934 25348397 7651724 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PRLR TEC 11328862 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
BTK TEC 11598012 12445832 12573241 14525934 25348397 8629002 8630736 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TEC KIT 14525934 24234451 24728074 25348397 7526158 N/A experimental interaction detection,fluorescence polarization spectroscopy,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
TEC PTPN21 11013262 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
TEC SOCS1 14525934 25348397 9341160 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
TEC PIK3R3 14525934 25348397 9178903 N/A two hybrid,two hybrid ComPPI,HPRD
TEC PLK4 11489907 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
TEC LYN 14525934 25348397 8621063 9446655 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TEC PIK3R1 14525934 25348397 9178903 N/A experimental interaction detection,in vivo ComPPI,HPRD
TEC PLCG2 25348397 N/A in vitro ComPPI
TEC SHC1 11825908 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TEC DOK1 10823839 11071635 11825908 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TEC PIP5K1A 25348397 N/A in vitro,in vivo ComPPI
TEC PIP4K2A 14525934 14614854 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
TEC JAK1 14525934 25348397 9178903 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TEC JAK2 14525934 25348397 9473212 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TEC GNA12 12515866 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
TEC ARHGEF12 25348397 N/A physical interaction ComPPI
TEC IKBKG 25348397 N/A physical interaction ComPPI
TEC FASLG 19807924 24234451 25348397 N/A phage display,physical interaction ComPPI,IntAct
TEC GRB2 21706016 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TEC RPE 25348397 N/A physical interaction ComPPI
TEC SORT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TEC PTPRC 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
TEC PTPRK 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
TEC PTPRG 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
TEC PTPRB 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
TEC PTPRJ 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
TEC PTPRO 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
TEC PTPN12 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
TEC ASAP1 16636290 24234451 25348397 N/A enzyme linked immunosorbent assay ComPPI,IntAct
TEC MET 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
GAB1 TEC 24234451 24728074 25348397 N/A fluorescence polarization spectroscopy ComPPI,IntAct
BMX TEC 12573241 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MED28 TEC 16964398 24234451 25348397 physical association peptide array,physical interaction ComPPI,IntAct
TEC TEC 12573241 14525934 N/A experimental interaction detection HPRD
PLCG1 TEC 10823839 14525934 N/A experimental interaction detection HPRD
TP53 TEC 14525934 15355990 N/A experimental interaction detection HPRD
H1-0 TEC 24234451 30021884 physical association cross-linking study IntAct
IKBKG TEC 20098747 27898060 N/A N/A OmniPath
TEC BTK 11598012 12445832 12573241 16497976 27898060 8629002 8630736 stimulant N/A OmniPath
BTK TEC 11598012 12445832 12573241 27898060 8629002 8630736 stimulant N/A OmniPath
TEC GRB10 27898060 9753425 N/A N/A OmniPath
TEC FGF2 20230531 27898060 N/A N/A OmniPath
TEC BMX 12573241 27898060 stimulant N/A OmniPath
ITK TEC 12573241 27898060 stimulant N/A OmniPath
TEC PTPN18 14679216 15588985 23322602 27898060 N/A N/A OmniPath

Visualization










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