GENE:CERS4
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | CERS4 |
| FullNmae | ceramide synthase 4 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:23747 |
| EnsembleID | ENSG00000090661 |
| Uniprot | Q9HA82 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| CERS4 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| CERS4 | GO:0003677,GO:0005515,GO:0005789,GO:0030148,GO:0046513,GO:0046513,GO:0050291,GO:0050291,GO:0050291 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| CERS4 | hsa:79603 | path:hsa00600 | Sphingolipid metabolism - Homo sapiens (human) |
| CERS4 | hsa:79603 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| CERS4 | hsa:79603 | path:hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | CERS4 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | CERS4 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | CERS4 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | CERS4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | CERS4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | CERS4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | CERS4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | CERS4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | CERS4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | CERS4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | CERS4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | CERS4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | CERS4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000B59A2 | CERS4 | 23708386 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000544FF1 | CERS4 | 23708386 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005CCD18 | CERS4 | 23708386 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000CC005 | CERS4 | 19536157 23708386 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000085F64 | CERS4 | 23708386 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AA845 | CERS4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C0FCB | CERS4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000122F23 | CERS4 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS0000008A99 | CERS4 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00004CCA62 | CERS4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000272A92 | CERS4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075AB14 | CERS4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000011DF | CERS4 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000237AF9 | CERS4 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075A513 | CERS4 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000010F787 | CERS4 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000009A9A2 | CERS4 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C48FA | CERS4 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C770D | CERS4 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00004F2EB0 | CERS4 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C4DB5 | CERS4 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00002152A8 | CERS4 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AB32B | CERS4 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000027352D | CERS4 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00003D4175 | CERS4 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000075A760 | CERS4 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00001481F9 | CERS4 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00001496AE | CERS4 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000075BDAA | CERS4 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000075B538 | CERS4 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS0000259AE4 | CERS4 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EC1BE | CERS4 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS0000512C88 | CERS4 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000041FA2C | CERS4 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CSNK2A1 | CERS4 | 22135298 | phosphorylation | N/A | PhosphoSite |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| UPK1B | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| JAGN1 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SERP2 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| LHFPL5 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| FATE1 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SLC7A1 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| PTPN9 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| STX8 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| NEU1 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| STX7 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| PLP2 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| MS4A1 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ITGAM | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SCD | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CYB5R3 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| NAT8 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| IGFBP5 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SCAMP5 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| FXYD6 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SLC35F6 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| LPAR1 | CERS4 | 25348397 | N/A | physical interaction | ComPPI |
| GPR151 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| IER3IP1 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SMIM11A | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| IPPK | CERS4 | 25348397 | N/A | physical interaction | ComPPI |
| TMEM176A | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CCL4L1 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CLEC1A | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| SLC35A1 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| TOMM6 | CERS4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CERS4 | SLC13A4 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CERS4 | TMEM254 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| CERS4 | TMEM72 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
