GENE：EPHA4
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | EPHA4 |
| FullNmae | EPH receptor A4 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3388 |
| EnsembleID | ENSG00000116106 |
| Uniprot | P54764 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| EPHA4 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| EPHA4 | GO:0001540,GO:0004672,GO:0004713,GO:0005004,GO:0005005,GO:0005005,GO:0005515,GO:0005524,GO:0005737,GO:0005741,GO:0005886,GO:0005886,GO:0005886,GO:0005912,GO:0006468,GO:0007155,GO:0007162,GO:0007411,GO:0007628,GO:0008045,GO:0008284,GO:0008347,GO:0009986,GO:0010719,GO:0010977,GO:0016301,GO:0017148,GO:0018108,GO:0021957,GO:0030175,GO:0030335,GO:0030336,GO:0030424,GO:0030425,GO:0030425,GO:0031594,GO:0031901,GO:0034332,GO:0042731,GO:0042734,GO:0042802,GO:0043087,GO:0043197,GO:0043198,GO:0043204,GO:0043679,GO:0044295,GO:0045785,GO:0046777,GO:0046875,GO:0048013,GO:0048013,GO:0048681,GO:0048710,GO:0050770,GO:0050775,GO:0050821,GO:0061001,GO:0061098,GO:0070373,GO:0072178,GO:0090102,GO:0097155,GO:0097156,GO:0097161,GO:0097485,GO:0098685,GO:0098839,GO:0098883,GO:0098978,GO:0106030,GO:1900038,GO:1900272,GO:1902004,GO:1902961,GO:1903051,GO:1904646,GO:1905244,GO:1905806,GO:1990782,GO:2001108 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| EPHA4 | hsa:2043 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| IKBKG | EPHA4 | 20098747 23180781 | physical association | protein array | InnateDB |
| EPHA4 | POLR2F | 23180781 23994473 | physical association | anti tag coimmunoprecipitation | InnateDB |
| EFNA1 | EPHA4 | 23331499 9576626 | stimulation | N/A | SignaLink,SignaLink |
| EFNA5 | EPHA4 | 18988627 23331499 8755474 9576626 | stimulation | N/A | SignaLink,SignaLink |
| EPHA4 | NGEF | 11336673 21071413 23331499 | stimulation | N/A | SignaLink,SignaLink |
| EFNA4 | EPHA4 | 23331499 9267020 | stimulation | N/A | SignaLink |
| EPHA4 | ARHGEF15 | 12775584 23331499 | stimulation | N/A | SignaLink |
| EPHA4 | FYN | 12084815 23331499 | stimulation | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | EPHA4 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | EPHA4 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ESR1 | EPHA4 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| ETS1 | EPHA4 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | EPHA4 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | EPHA4 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | EPHA4 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | EPHA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | EPHA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | EPHA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | EPHA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | EPHA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | EPHA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | EPHA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | EPHA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | EPHA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | EPHA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | EPHA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | EPHA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000016D2D4 | EPHA4 | 22996586 | rna interference,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry | miRSponge |
| URS000016D2D4 | EPHA4 | 22996586 23622248 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,clash | TarBase |
| URS0000237AF9 | EPHA4 | 18185580 21572407 25416803 | mrna cleavage,inhibition | array technology,clip | TarBase |
| URS00002C0FCB | EPHA4 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS0000028BB8 | EPHA4 | 17612493 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000DDD35 | EPHA4 | 20371350 21572407 23622248 25416803 | mrna cleavage,inhibition | nucleotide sequence identification,clip,clash | TarBase |
| URS000009262D | EPHA4 | 18591254 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000017EA6A | EPHA4 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00000CF1D2 | EPHA4 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00003CF1AD | EPHA4 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00004AC389 | EPHA4 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000096022 | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000008A99 | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000037D7E5 | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003883FE | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000012930C | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000039E1E1 | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000600E6 | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002075FA | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000042E1F | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B3783 | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000298BA3 | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003CC709 | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003D8730 | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004407DC | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001496AE | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000F7766 | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000025EABA | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006F90B | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000324096 | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000031E12 | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000237CBD | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000A07C1 | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032EF64 | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000029979D | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000000B1C9 | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000122ED0 | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004CCA62 | EPHA4 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000000EF0B | EPHA4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003E226A | EPHA4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000044FD7 | EPHA4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000029D9F1 | EPHA4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000018CD09 | EPHA4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000010BD8D | EPHA4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075ABF4 | EPHA4 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004F507C | EPHA4 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000072B4C8 | EPHA4 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00007455B8 | EPHA4 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| EPHA4 | EPHA4 | 22135298 25361965 | interaction type,phosphorylation | N/A | PhosphoSite,PTMCode2 |
| EFNB3 | EPHA4 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA4 | EFNB3 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNB2 | EPHA4 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA4 | EFNB2 | 25361965 | interaction type | N/A | PTMCode2 |
| CRK | EPHA4 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA4 | CRK | 25361965 | interaction type | N/A | PTMCode2 |
| NGEF | EPHA4 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA4 | NGEF | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA4 | EFNA5 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNA5 | EPHA4 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA4 | SRC | 25361965 | interaction type | N/A | PTMCode2 |
| SRC | EPHA4 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA4 | ARHGEF15 | 25361965 | interaction type | N/A | PTMCode2 |
| ARHGEF15 | EPHA4 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA4 | EFNA1 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNA1 | EPHA4 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA4 | EFNA3 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNA3 | EPHA4 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA4 | FYN | 25361965 | interaction type | N/A | PTMCode2 |
| FYN | EPHA4 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA4 | EFNA4 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNA4 | EPHA4 | 25361965 | interaction type | N/A | PTMCode2 |
| EFNA2 | EPHA4 | 25361965 | interaction type | N/A | PTMCode2 |
| EPHA4 | EFNA2 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RSPH14 | EPHA4 | 25348397 | N/A | physical interaction | ComPPI |
| ARHGEF15 | EPHA4 | 12775584 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| TUBB | EPHA4 | 25348397 | N/A | physical interaction | ComPPI |
| HSP90AB1 | EPHA4 | 22939624 24234451 25348397 | physical association | luminescence based mammalian interactome mapping | ComPPI,IntAct |
| SLC1A1 | EPHA4 | 25348397 | N/A | physical interaction | ComPPI |
| SRC | EPHA4 | 25348397 | N/A | physical interaction | ComPPI |
| FGFR2 | EPHA4 | 25348397 | N/A | two hybrid,physical interaction,in vivo | ComPPI |
| FZR1 | EPHA4 | 25348397 | N/A | physical interaction | ComPPI |
| FRS2 | EPHA4 | 25348397 | N/A | physical interaction | ComPPI |
| HSP90AA1 | EPHA4 | 25348397 | N/A | physical interaction | ComPPI |
| EFNA4 | EPHA4 | 10366629 14525934 19836338 24234451 25348397 | N/A | experimental interaction detection,surface plasmon resonance,physical interaction,in vivo,surface plasmon resonance array | ComPPI,HPRD,IntAct |
| EFNA5 | EPHA4 | 14525934 19836338 23812375 24234451 25348397 8755474 | N/A | experimental interaction detection,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,surface plasmon resonance array | ComPPI,HPRD,IntAct |
| EFNA1 | EPHA4 | 14525934 19836338 24234451 25348397 8755474 | N/A | experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,surface plasmon resonance array | ComPPI,HPRD,IntAct |
| EFNA3 | EPHA4 | 12496762 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| EFNA2 | EPHA4 | 19836338 24234451 25348397 | physical association | molecular sieving,pull down,surface plasmon resonance,x-ray crystallography,physical interaction,surface plasmon resonance array | ComPPI,IntAct |
| EFNB2 | EPHA4 | 12761826 14525934 19836338 24234451 25348397 | physical association | experimental interaction detection,molecular sieving,pull down,surface plasmon resonance,x-ray crystallography,physical interaction,in vivo,surface plasmon resonance array | ComPPI,HPRD,IntAct |
| FGFR3 | EPHA4 | 14525934 16365308 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid | ComPPI,HPRD |
| FGFR1 | EPHA4 | 25348397 | N/A | two hybrid,physical interaction,in vivo | ComPPI |
| VHL | EPHA4 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | EFNB3 | 12383247 14525934 23812375 24234451 25348397 9484836 | N/A | experimental interaction detection,x-ray crystallography,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
| EPHA4 | NGEF | 11336673 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid | ComPPI,HPRD |
| EPHA4 | FGFR4 | 14525934 16365308 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| EPHA4 | FYN | 12084815 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| EPHA4 | IKBKG | 20098747 24234451 25348397 | N/A | protein array,physical interaction | ComPPI,IntAct |
| EPHA4 | RYK | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | ANAPC2 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | HSP90AA2P | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | TSPAN3 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | HLA-DPA1 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | GPN3 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | CEACAM21 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | GNAT2 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | RIPK3 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | TUBB2B | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | TBC1D22A | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | IARS2 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | CPA5 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | RFC4 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | CYP1A2 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | EPHA7 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | OS9 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | KLRG2 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | HDAC10 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | GBP5 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | UMPS | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | ARMC6 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | MMP26 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | TNS3 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | BET1 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| EPHA4 | TGOLN2 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| GNAZ | EPHA4 | 25348397 | N/A | physical interaction | ComPPI |
| FAM118B | EPHA4 | 25348397 | N/A | physical interaction | ComPPI |
| FABP1 | EPHA4 | 25348397 | N/A | physical interaction | ComPPI |
| EPHA4 | EPHA4 | 14525934 23812375 24234451 8622893 | N/A | experimental interaction detection,x-ray crystallography | HPRD,IntAct |
| EPHA4 | FYN | 12084815 27898060 | stimulant | N/A | OmniPath |
| MAP3K1 | EPHA4 | 27898060 7997270 | stimulant | N/A | OmniPath |
| IKBKG | EPHA4 | 20098747 27898060 | N/A | N/A | OmniPath |
| EFNA5 | EPHA4 | 19836338 23812375 27898060 8755474 9330863 9576626 | stimulant | N/A | OmniPath |
| EPHA4 | NGEF | 11336673 27898060 | stimulant | N/A | OmniPath |
| EFNA2 | EPHA4 | 19836338 27898060 9330863 | stimulant | N/A | OmniPath |
| EFNB3 | EPHA4 | 12383247 23812375 27898060 9330863 9484836 | stimulant | N/A | OmniPath |
| EFNA1 | EPHA4 | 15114347 19836338 27898060 8755474 9330863 9576626 | stimulant | N/A | OmniPath |
| EFNA4 | EPHA4 | 10366629 15114347 19836338 27898060 | N/A | N/A | OmniPath |
| EFNA3 | EPHA4 | 12496762 27898060 9330863 | stimulant | N/A | OmniPath |
| PTPRO | EPHA4 | 16680165 27898060 | N/A | N/A | OmniPath |