GENE：ARL8B
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ARL8B |
| FullNmae | ADP ribosylation factor like GTPase 8B |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:25564 |
| EnsembleID | ENSG00000134108 |
| Uniprot | Q9NVJ2 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ARL8B | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| ARL8B | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| ARL8B | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ARL8B | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ARL8B | GO:0001778,GO:0002505,GO:0002747,GO:0003924,GO:0003925,GO:0005515,GO:0005525,GO:0005525,GO:0005737,GO:0005764,GO:0005764,GO:0005765,GO:0005765,GO:0005829,GO:0007059,GO:0008089,GO:0015031,GO:0016020,GO:0016197,GO:0019003,GO:0019003,GO:0030496,GO:0031902,GO:0032418,GO:0032418,GO:0042267,GO:0043014,GO:0045202,GO:0046754,GO:0048487,GO:0051233,GO:0051301,GO:0061909,GO:0070062,GO:0090117,GO:0090385,GO:0101004,GO:1902774,GO:1902774,GO:1904115,GO:1990927 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ARL8B | hsa:55207 | path:hsa05132 | Salmonella infection - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ARL8B | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | ARL8B | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | ARL8B | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | ARL8B | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | ARL8B | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | ARL8B | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | ARL8B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ARL8B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ARL8B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | ARL8B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | ARL8B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ARL8B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ARL8B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ARL8B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ARL8B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | ARL8B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | ARL8B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000521626 | ARL8B | 17612493 23592263 25416803 | mrna cleavage,inhibition | array technology,clip | TarBase |
| URS0000338542 | ARL8B | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS000003ABC4 | ARL8B | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00003BBF48 | ARL8B | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000000C73C | ARL8B | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004BCD9C | ARL8B | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000039607D | ARL8B | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000160683 | ARL8B | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000054DF42 | ARL8B | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001E96DA | ARL8B | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000AD002 | ARL8B | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00006AA21F | ARL8B | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002CCA6E | ARL8B | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000136174 | ARL8B | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B7E30 | ARL8B | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000480E22 | ARL8B | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000043B1D | ARL8B | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B1B47 | ARL8B | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000025307A | ARL8B | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000328C0D | ARL8B | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000451A1 | ARL8B | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002A8BC6 | ARL8B | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075A760 | ARL8B | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002152A8 | ARL8B | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000137EDE | ARL8B | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000019907A | ARL8B | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C770D | ARL8B | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003D8730 | ARL8B | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000122ED0 | ARL8B | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032EF64 | ARL8B | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000237CBD | ARL8B | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000029979D | ARL8B | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000000B1C9 | ARL8B | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000A07C1 | ARL8B | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000031E12 | ARL8B | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000324096 | ARL8B | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006372A | ARL8B | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000527B00 | ARL8B | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000355E82 | ARL8B | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003FBC84 | ARL8B | 23706177 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TBC1D22B | ARL8B | 25348397 | N/A | physical interaction | ComPPI |
| TUBB | ARL8B | 15331635 25348397 27898060 | N/A | physical interaction,in vitro | ComPPI,OmniPath |
| ALPI | ARL8B | 25348397 | N/A | physical interaction | ComPPI |
| RAB7A | ARL8B | 25348397 | N/A | physical interaction | ComPPI |
| RAB2A | ARL8B | 25348397 | N/A | physical interaction | ComPPI |
| ARL8B | ELAVL1 | 25348397 | N/A | physical interaction | ComPPI |
| ARL8B | APP | 25348397 | N/A | physical interaction | ComPPI |
| ARL8B | AMH | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| ARL8B | BTN3A3 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| ARL8B | SRPRB | 25348397 | N/A | physical interaction | ComPPI |
| ARL8B | SSR4 | 25348397 | N/A | physical interaction | ComPPI |
| ARL8B | DUSP19 | 25348397 | N/A | physical interaction | ComPPI |
| ARL8B | DUSP9 | 25348397 | N/A | physical interaction | ComPPI |
| ARL8B | MAS1 | 25348397 | N/A | physical interaction | ComPPI |
| ARL8B | CPLX3 | 25348397 | N/A | physical interaction | ComPPI |
| ARL8B | RAET1E | 25348397 | N/A | physical interaction | ComPPI |
| ARL8B | IL17RC | 25348397 | N/A | physical interaction | ComPPI |
| ARL8B | A2M | 17174955 24234451 25348397 | colocalization | cosedimentation through density gradient | ComPPI,IntAct |
| ARL8B | PTBP3 | 22575643 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| ARL8B | CIDEB | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| ARL8B | TUBB2A | 14525934 15331635 | N/A | experimental interaction detection | HPRD |
| ARL8B | TGFBR1 | 14525934 15761153 | N/A | experimental interaction detection | HPRD |