Gene Information gene info

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GENE：GATA1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GATA1
FullNmae GATA binding protein 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4170
EnsembleID ENSG00000102145
Uniprot P15976

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GATA1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GATA1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GATA1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
GATA1 GO:0000122,GO:0000122,GO:0000785,GO:0000976,GO:0000977,GO:0000978,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001221,GO:0001223,GO:0001228,GO:0001701,GO:0002039,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005667,GO:0006366,GO:0007204,GO:0007267,GO:0008270,GO:0008285,GO:0008584,GO:0010559,GO:0010724,GO:0010725,GO:0017053,GO:0030218,GO:0030219,GO:0030220,GO:0030221,GO:0030222,GO:0030282,GO:0030502,GO:0031100,GO:0031490,GO:0032993,GO:0033028,GO:0033033,GO:0033687,GO:0033690,GO:0035854,GO:0043066,GO:0043306,GO:0043565,GO:0045165,GO:0045648,GO:0045893,GO:0045944,GO:0045944,GO:0045944,GO:0048821,GO:0048873,GO:0050731,GO:0060009,GO:0060319,GO:0061629,GO:0070527,GO:0070742,GO:0071222,GO:0071320,GO:0071372,GO:0097028,GO:0097067,GO:1990837,GO:2000678,GO:2001240

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TIMP1 GATA1 16107690 23180781 physical association anti tag coimmunoprecipitation InnateDB
AKT1 GATA1 16107690 23180781 phosphorylation reaction protein kinase assay InnateDB
IL2RA GATA1 23180781 8896456 physical association electrophoretic mobility supershift assay InnateDB
PRG2 GATA1 12202480 23180781 physical association electrophoretic mobility supershift assay InnateDB
CEBPE GATA1 12202480 23180781 physical association anti tag coimmunoprecipitation InnateDB
SPI1 GATA1 10411939 23180781 physical association anti tag coimmunoprecipitation InnateDB
CLDN5 GATA1 23180781 24318462 physical association anti tag coimmunoprecipitation InnateDB
OCLN GATA1 23180781 24318462 physical association anti tag coimmunoprecipitation InnateDB
TJP1 GATA1 23180781 24318462 physical association anti tag coimmunoprecipitation InnateDB
CCR3 GATA1 23180781 23636060 physical association anti tag coimmunoprecipitation InnateDB
GATA1 FCER1A 23180781 24639354 physical association anti tag coimmunoprecipitation InnateDB
GATA1 MS4A2 23180781 24639354 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
GATA1 GATA1 16492768 17628529 19941826 20542454 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 GATA1 19279013 19941826 23071749 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 GATA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 GATA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
BCL11A GATA1 20542454 23071749 trascriptional regulation,stimulation inferred by curator TFlink
CBFB GATA1 8683991 trascriptional regulation,stimulation inferred by curator TFlink
CEBPE GATA1 12202480 trascriptional regulation,stimulation inferred by curator TFlink
FLI1 GATA1 12724402 trascriptional regulation,stimulation inferred by curator TFlink
MYC GATA1 18838534 trascriptional regulation,stimulation inferred by curator TFlink
POU2F1 GATA1 7499351 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 GATA1 11001896 20304827 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 GATA1 N/A trascriptional regulation,stimulation inferred by curator TFlink
ETS2 GATA1 N/A trascriptional regulation,stimulation inferred by curator TFlink
MYB GATA1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 GATA1 18185580 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
PAK5 GATA1 22135298 phosphorylation N/A PhosphoSite
AKT1 GATA1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
CEBPE GATA1 25361965 interaction type N/A PTMCode2
GATA1 CEBPE 25361965 interaction type N/A PTMCode2
STAT3 GATA1 25361965 interaction type N/A PTMCode2
GATA1 STAT3 25361965 interaction type N/A PTMCode2
TRIM33 GATA1 25361965 interaction type N/A PTMCode2
GATA1 TRIM33 25361965 interaction type N/A PTMCode2
ZNF521 GATA1 25361965 interaction type N/A PTMCode2
GATA1 ZNF521 25361965 interaction type N/A PTMCode2
MAPK1 GATA1 25361965 interaction type N/A PTMCode2
GATA1 MAPK1 25361965 interaction type N/A PTMCode2
SMARCA4 GATA1 25361965 interaction type N/A PTMCode2
GATA1 SMARCA4 25361965 interaction type N/A PTMCode2
CEBPB GATA1 25361965 interaction type N/A PTMCode2
GATA1 CEBPB 25361965 interaction type N/A PTMCode2
CASP3 GATA1 25361965 interaction type N/A PTMCode2
GATA1 CASP3 25361965 interaction type N/A PTMCode2
SPI1 GATA1 25361965 interaction type N/A PTMCode2
GATA1 SPI1 25361965 interaction type N/A PTMCode2
GATA1 AKT1 25361965 interaction type N/A PTMCode2
HDAC5 GATA1 25361965 interaction type N/A PTMCode2
GATA1 HDAC5 25361965 interaction type N/A PTMCode2
HDAC3 GATA1 25361965 interaction type N/A PTMCode2
GATA1 HDAC3 25361965 interaction type N/A PTMCode2
ZFPM1 GATA1 25361965 interaction type N/A PTMCode2
GATA1 ZFPM1 25361965 interaction type N/A PTMCode2
GATA1 ZFPM2 25361965 interaction type N/A PTMCode2
ZFPM2 GATA1 25361965 interaction type N/A PTMCode2
GATA1 CREB1 25361965 interaction type N/A PTMCode2
CREB1 GATA1 25361965 interaction type N/A PTMCode2
LMO2 GATA1 25361965 interaction type N/A PTMCode2
GATA1 LMO2 25361965 interaction type N/A PTMCode2
IKZF1 GATA1 25361965 interaction type N/A PTMCode2
GATA1 IKZF1 25361965 interaction type N/A PTMCode2
HDAC4 GATA1 25361965 interaction type N/A PTMCode2
GATA1 HDAC4 25361965 interaction type N/A PTMCode2
HEY1 GATA1 25361965 interaction type N/A PTMCode2
GATA1 HEY1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KRTAP9-2 GATA1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SMARCE1 GATA1 25348397 N/A physical interaction ComPPI
FRS3 GATA1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
HOXA1 GATA1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRTAP10-5 GATA1 24234451 25348397 25416956 physical association two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
HEXIM2 GATA1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TAX1BP3 GATA1 25348397 N/A physical interaction ComPPI
ZBTB22 GATA1 25348397 N/A physical interaction ComPPI
SMARCC1 GATA1 25348397 N/A physical interaction ComPPI
MED21 GATA1 17132730 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
MAPK1 GATA1 14525934 15967790 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SP1 GATA1 25348397 N/A physical interaction ComPPI
SPI1 GATA1 10364157 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FLI1 GATA1 10364157 12556498 12724402 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
CASP3 GATA1 14525934 17167422 24234451 25348397 colocalization,protein cleavage experimental interaction detection,physical interaction,protease assay,in vitro,confocal microscopy ComPPI,HPRD,IntAct
MAPK3 GATA1 14525934 15967790 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RB1 GATA1 19513100 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CREBBP GATA1 12496368 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SMARCD1 GATA1 25348397 N/A physical interaction ComPPI
EP300 GATA1 25348397 N/A physical interaction ComPPI
SPIB GATA1 25348397 N/A physical interaction ComPPI
HDAC3 GATA1 25348397 N/A physical interaction ComPPI
GATA1 LMO2 14525934 25348397 7568177 9209374 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
GATA1 ZFPM2 10438528 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
GATA1 MED1 11724781 14525934 17132730 24234451 25348397 27898060 association,physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct,OmniPath
GATA1 HDAC5 14525934 14668799 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GATA1 ZBTB16 12242665 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
GATA1 CEBPE 12202480 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
GATA1 STAT3 14525934 15673499 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GATA1 HEY1 14525934 15314183 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GATA1 ZFPM1 11675338 14525934 15920471 19513100 19654328 24234451 25348397 27898060 9230307 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
GATA1 AKT1 14525934 16107690 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GATA1 HSPA4 14525934 17167422 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GATA1 ZNF521 14525934 19049973 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GATA1 HDAC1 25348397 N/A physical interaction ComPPI
GATA1 HDAC4 25348397 N/A physical interaction ComPPI
GATA1 ARID1A 25348397 N/A physical interaction ComPPI
GATA1 SMARCA4 25348397 N/A physical interaction ComPPI
GATA1 SMARCC2 25348397 N/A physical interaction ComPPI
GATA1 SMARCB1 25348397 N/A physical interaction ComPPI
GATA1 TAL1 25348397 N/A physical interaction ComPPI
GATA1 MED14 17132730 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
GATA1 MED17 17132730 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
GATA1 IKZF1 25348397 N/A physical interaction ComPPI
GATA1 TAF7 25348397 N/A physical interaction ComPPI
GATA1 TRIM25 25348397 N/A physical interaction ComPPI
GATA1 RAI1 25348397 N/A physical interaction ComPPI
GATA1 TRIM29 25348397 N/A physical interaction ComPPI
GATA1 ZZZ3 25348397 N/A physical interaction ComPPI
GATA1 NME1 25348397 N/A physical interaction ComPPI
GATA1 SKI 25348397 N/A physical interaction ComPPI
GATA1 HSPB1 20410505 25348397 27898060 N/A physical interaction ComPPI,OmniPath
GATA1 SRA1 25348397 N/A physical interaction ComPPI
GATA1 PRKAA1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GATA1 PRKAB2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
GATA1 RADIL 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
GATA1 FBF1 25348397 N/A physical interaction ComPPI
GATA1 CCDC24 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
GATA1 ZDHHC17 25348397 N/A physical interaction ComPPI
GATA1 DHX36 25348397 N/A physical interaction ComPPI
GATA1 TRIP6 25348397 N/A physical interaction ComPPI
GATA1 RIN3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GATA1 TNS2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GATA1 HEMGN 25348397 N/A physical interaction ComPPI
GATA1 PML 25348397 N/A physical interaction ComPPI
GATA1 DNMT3L 25348397 N/A physical interaction ComPPI
GATA1 MED19 17132730 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
GATA1 CCNC 17132730 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
GATA1 MED16 17132730 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
GATA1 MED20 17132730 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
GATA1 UBC 16858405 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
GATA1 HSPA1A 17167422 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,confocal microscopy ComPPI,IntAct
GATA1 HSPA1B 25348397 N/A confocal microscopy ComPPI
MAPK6 GATA1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GATA1 YY1 15913647 27898060 N/A N/A OmniPath
GATA1 SPI1 10364157 10411939 10753833 12202480 15676205 27898060 inhibition N/A OmniPath
SPI1 GATA1 10364157 10411939 10753833 12202480 15676205 27898060 inhibition N/A OmniPath
AKT1 GATA1 16107690 20101202 27898060 stimulant N/A OmniPath
MAPK3 GATA1 15967790 16107690 27898060 stimulant N/A OmniPath
GATA1 RUNX1 17725493 27898060 stimulant N/A OmniPath
DAB2IP GATA1 27858941 27898060 stimulant N/A OmniPath
PAK5 GATA1 25726523 27898060 N/A N/A OmniPath

Visualization










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