Gene Information gene info

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GENE：CACNA1D

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CACNA1D
FullNmae calcium voltage-gated channel subunit alpha1 D
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1391
EnsembleID ENSG00000157388
Uniprot Q01668

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CACNA1D immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CACNA1D GO:0005245,GO:0005262,GO:0005515,GO:0005886,GO:0005886,GO:0005891,GO:0005891,GO:0006816,GO:0007188,GO:0007605,GO:0008331,GO:0030018,GO:0030506,GO:0045762,GO:0046872,GO:0051393,GO:0051928,GO:0060372,GO:0070509,GO:0070588,GO:0086002,GO:0086007,GO:0086012,GO:0086046,GO:0086059,GO:0086091,GO:0098703,GO:1901016,GO:1901379,GO:1990454

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CACNA1D hsa:776 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04218 Cellular senescence - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04260 Cardiac muscle contraction - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04530 Tight junction - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04713 Circadian entrainment - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04724 Glutamatergic synapse - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04726 Serotonergic synapse - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04727 GABAergic synapse - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04728 Dopaminergic synapse - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04911 Insulin secretion - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04924 Renin secretion - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04927 Cortisol synthesis and secretion - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04929 GnRH secretion - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04930 Type II diabetes mellitus - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04934 Cushing syndrome - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
CACNA1D hsa:776 path:hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human)
CACNA1D hsa:776 path:hsa05010 Alzheimer disease - Homo sapiens (human)
CACNA1D hsa:776 path:hsa05020 Prion disease - Homo sapiens (human)
CACNA1D hsa:776 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
CACNA1D hsa:776 path:hsa05031 Amphetamine addiction - Homo sapiens (human)
CACNA1D hsa:776 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)
CACNA1D hsa:776 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)
CACNA1D hsa:776 path:hsa05412 Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)
CACNA1D hsa:776 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR CACNA1D 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 CACNA1D 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 CACNA1D 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP53 CACNA1D 18922183 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 CACNA1D 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 CACNA1D 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CACNA1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CACNA1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CACNA1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CACNA1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CACNA1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CACNA1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CACNA1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CACNA1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 CACNA1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CACNA1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 CACNA1D 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000204177 CACNA1D 24374217 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
FGFR2 CACNA1D 25348397 N/A in vivo ComPPI
ACTN2 CACNA1D 19815520 24234451 25348397 N/A two hybrid,physical interaction ComPPI,IntAct
STX1A CACNA1D 10468580 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CALB1 CACNA1D 25348397 N/A physical interaction ComPPI

Visualization










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