GENE：NOG
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | NOG |
| FullNmae | noggin |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:7866 |
| EnsembleID | ENSG00000183691 |
| Uniprot | Q13253 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| NOG | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NOG | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| NOG | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| NOG | GO:0000122,GO:0001501,GO:0001649,GO:0001649,GO:0001701,GO:0001706,GO:0001707,GO:0001837,GO:0001839,GO:0001843,GO:0003149,GO:0003151,GO:0003223,GO:0003272,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0007224,GO:0007399,GO:0008045,GO:0008542,GO:0009953,GO:0009953,GO:0010628,GO:0010629,GO:0019955,GO:0021510,GO:0021533,GO:0021983,GO:0030336,GO:0030509,GO:0030514,GO:0030514,GO:0030514,GO:0035019,GO:0035640,GO:0042060,GO:0042474,GO:0042733,GO:0042803,GO:0045668,GO:0045944,GO:0048168,GO:0048318,GO:0048570,GO:0048706,GO:0048712,GO:0048863,GO:0050673,GO:0050679,GO:0051216,GO:0055009,GO:0060044,GO:0060173,GO:0060272,GO:0060291,GO:0060302,GO:0060325,GO:0060412,GO:0060425,GO:0060513,GO:0060676,GO:0060825,GO:0061037,GO:0061053,GO:0061384,GO:0061626,GO:0062044,GO:0090090,GO:0090190,GO:0090193,GO:0098793,GO:0099171,GO:1904888,GO:1990926,GO:2000313,GO:2001234 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| NOG | hsa:9241 | path:hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | NOG | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | NOG | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | NOG | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | NOG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | NOG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | NOG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | NOG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | NOG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | NOG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | NOG | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NOG | BMP2 | 25361965 | interaction type | N/A | PTMCode2 |
| BMP2 | NOG | 25361965 | interaction type | N/A | PTMCode2 |
| NOG | BMP7 | 25361965 | interaction type | N/A | PTMCode2 |
| BMP7 | NOG | 25361965 | interaction type | N/A | PTMCode2 |
| BMP4 | NOG | 25361965 | interaction type | N/A | PTMCode2 |
| NOG | BMP4 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BMP7 | NOG | 12478285 14525934 24234451 25348397 | N/A | experimental interaction detection,x-ray crystallography,physical interaction | ComPPI,HPRD,IntAct |
| BMP4 | NOG | 10657699 11706034 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| BMP2 | NOG | 10657699 14525934 15064755 19804412 24234451 25348397 | N/A | experimental interaction detection,surface plasmon resonance,in vitro,in vivo,surface plasmon resonance array | ComPPI,HPRD,IntAct |
| GDF5 | NOG | 16127465 24234451 25348397 | N/A | surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| NOG | BMP5 | 11580864 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| NOG | BMP4 | 10657699 11706034 12700180 27898060 | inhibition | N/A | OmniPath |
| NOG | BMPR1A | 22298955 27898060 | inhibition | N/A | OmniPath |
| NOG | BMPR1B | 22298955 27898060 | inhibition | N/A | OmniPath |
| NOG | BMP2 | 10657699 12700180 15064755 19804412 27898060 | inhibition | N/A | OmniPath |
| NOG | BMPR2 | 22298955 27898060 | inhibition | N/A | OmniPath |
| NOG | GDF5 | 16127465 19956691 21976273 27898060 | inhibition | N/A | OmniPath |