GENE：RAC3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | RAC3 |
| FullNmae | Rac family small GTPase 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9803 |
| EnsembleID | ENSG00000169750 |
| Uniprot | P60763 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| RAC3 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| RAC3 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| RAC3 | GO:0003924,GO:0003924,GO:0003925,GO:0005515,GO:0005525,GO:0005789,GO:0005829,GO:0005856,GO:0005886,GO:0005886,GO:0005886,GO:0007015,GO:0007163,GO:0008045,GO:0008360,GO:0012505,GO:0014041,GO:0016055,GO:0016601,GO:0019901,GO:0021894,GO:0030027,GO:0030031,GO:0030031,GO:0030036,GO:0030426,GO:0030865,GO:0031410,GO:0031941,GO:0032956,GO:0033630,GO:0035556,GO:0043005,GO:0043005,GO:0043020,GO:0043025,GO:0043652,GO:0045730,GO:0048306,GO:0048471,GO:0048873,GO:0050885,GO:0051932,GO:0060326,GO:0070062,GO:0071944,GO:0098974,GO:0098974,GO:0098978,GO:0098978,GO:1900026,GO:1902622 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| RAC3 | hsa:5881 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa04510 | Focal adhesion - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa04520 | Adherens junction - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa05135 | Yersinia infection - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa05170 | Human immunodeficiency virus 1 infection - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa05210 | Colorectal cancer - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa05416 | Viral myocarditis - Homo sapiens (human) |
| RAC3 | hsa:5881 | path:hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000137EDE | RAC3 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00000CBE63 | RAC3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003A5E54 | RAC3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003808EC | RAC3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000BF7F9 | RAC3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005DEC41 | RAC3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000048D44E | RAC3 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005651EE | RAC3 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002D349B | RAC3 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000000EF0B | RAC3 | 19536157 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| LDHB | RAC3 | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| WAS | RAC3 | 14521508 24234451 25348397 | physical association | pull down | ComPPI,IntAct |
| XIAP | RAC3 | 22117219 24234451 25348397 | N/A | pull down | ComPPI,IntAct |
| RAC1 | RAC3 | 25348397 | N/A | physical interaction | ComPPI |
| SLC7A1 | RAC3 | 25348397 | N/A | physical interaction | ComPPI |
| PAK1 | RAC3 | 25348397 | N/A | pull down | ComPPI |
| ARHGDIB | RAC3 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| AR | RAC3 | 11747336 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| RHOC | RAC3 | 25348397 | N/A | physical interaction | ComPPI |
| ARHGDIA | RAC3 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| RAP1GDS1 | RAC3 | 25348397 | N/A | physical interaction | ComPPI |
| CIB1 | RAC3 | 11756406 14525934 25348397 27898060 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD,OmniPath |
| CACYBP | RAC3 | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| ANKRD11 | RAC3 | 14525934 15184363 25348397 | N/A | two hybrid,experimental interaction detection,in vitro,two hybrid | ComPPI,HPRD |
| RAC2 | RAC3 | 25348397 | N/A | physical interaction | ComPPI |
| RAC3 | HNF1A | 10777539 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| RAC3 | ESR1 | 21217774 24234451 25348397 | physical association | anti bait coimmunoprecipitation,two hybrid,phage display,pull down,physical interaction | ComPPI,IntAct |
| RAC3 | DUSP9 | 25348397 | N/A | physical interaction | ComPPI |
| RAC3 | RXRA | 17947383 24234451 25348397 | N/A | two hybrid,physical interaction | ComPPI,IntAct |
| RAC3 | HIVEP2 | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| RAC3 | CWC15 | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| RAC3 | ZNF706 | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| RAC3 | DDX46 | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| RAC3 | NCL | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| RAC3 | RSRC1 | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| RAC3 | RWDD1 | 20195357 24234451 25348397 | physical association | display technology | ComPPI,IntAct |
| RAC3 | PTBP3 | 22575643 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| RAC3 | ARFIP2 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| NRBP1 | RAC3 | 11956649 14525934 24234451 25348397 | physical association | anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,fluorescence microscopy,in vitro | ComPPI,HPRD,IntAct |
| RAC3 | PAK1 | 17625931 27898060 | stimulant | N/A | OmniPath |