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GENE：SCARB2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SCARB2
FullNmae scavenger receptor class B member 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1665
EnsembleID ENSG00000138760
Uniprot Q14108

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SCARB2 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
SCARB2 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
SCARB2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
SCARB2 GO:0000139,GO:0001618,GO:0001786,GO:0004888,GO:0005044,GO:0005044,GO:0005044,GO:0005515,GO:0005737,GO:0005765,GO:0005765,GO:0005765,GO:0005789,GO:0005886,GO:0005886,GO:0005886,GO:0005925,GO:0006622,GO:0006622,GO:0006622,GO:0006898,GO:0006898,GO:0007605,GO:0010008,GO:0010467,GO:0010976,GO:0015485,GO:0015917,GO:0016020,GO:0019899,GO:0030666,GO:0030669,GO:0031210,GO:0031902,GO:0038024,GO:0042803,GO:0043202,GO:0043470,GO:0046718,GO:0051087,GO:0070062,GO:1904978,GO:1905123,GO:1905671

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SCARB2 hsa:950 path:hsa04142 Lysosome - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR SCARB2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXA1 SCARB2 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SCARB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SCARB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SCARB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SCARB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SCARB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 SCARB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SCARB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SCARB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SCARB2 8007948 trascriptional regulation,stimulation inferred by curator TFlink
STAT2 SCARB2 17998316 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000031B6ED SCARB2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000153377 SCARB2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000272039 SCARB2 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000204177 SCARB2 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDAA SCARB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000016914 SCARB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA SCARB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000007FBA SCARB2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000000EF0B SCARB2 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A SCARB2 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000030F801 SCARB2 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001A122A SCARB2 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000005D4F5 SCARB2 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000243FF1 SCARB2 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001C308D SCARB2 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000157026 SCARB2 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 SCARB2 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
THBS1 SCARB2 25361965 interaction type N/A PTMCode2
SCARB2 THBS1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GEM SCARB2 25348397 N/A physical interaction ComPPI
LMNA SCARB2 25348397 N/A physical interaction ComPPI
NONO SCARB2 25348397 N/A physical interaction ComPPI
NTRK1 SCARB2 25348397 N/A physical interaction ComPPI
THBS1 SCARB2 14525934 25348397 27898060 9478926 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
EIF2AK2 SCARB2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAV1 SCARB2 25348397 N/A anti bait coimmunoprecipitation ComPPI
CSK SCARB2 25348397 N/A pull down ComPPI
VAMP3 SCARB2 25348397 N/A physical interaction ComPPI
GLMN SCARB2 25348397 N/A physical interaction ComPPI
SCARB2 AP3S1 12370188 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
SCARB2 ATP6V1B1 25348397 N/A physical interaction ComPPI
SCARB2 DDX1 25348397 N/A physical interaction ComPPI
SCARB2 HSPD1 25348397 N/A physical interaction ComPPI
SCARB2 TAF15 25348397 N/A physical interaction ComPPI
SCARB2 ATP4A 25348397 N/A physical interaction ComPPI
SCARB2 LGALS8 25348397 N/A physical interaction ComPPI
SCARB2 NAALADL2 25348397 N/A physical interaction ComPPI
SCARB2 PTPRK 25348397 N/A physical interaction ComPPI
SCARB2 CCN6 25348397 N/A physical interaction ComPPI
SCARB2 SMC6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SCARB2 PRPF8 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SCARB2 PNKD 25348397 N/A physical interaction ComPPI
SCARB2 MYOF 25348397 N/A physical interaction ComPPI
SCARB2 RHCG 25348397 N/A physical interaction ComPPI
SCARB2 SPAG9 25348397 N/A physical interaction ComPPI
SCARB2 SCGB1D1 25348397 N/A physical interaction ComPPI
SCARB2 A2M 17174955 24234451 25348397 colocalization cosedimentation through density gradient ComPPI,IntAct
SCARB2 PLCG1 25348397 N/A pull down ComPPI
SCARB2 ATP6V1A 21674799 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SCARB2 ERGIC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SCARB2 GPR37L1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SCARB2 GPX8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SCARB2 HIBADH 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RAB27B SCARB2 25348397 N/A physical interaction ComPPI

Source Target Pmid Interactiontype Methods Database
URS00009BD20F SCARB2 27087310 direct interaction,inhibition N/A NPInter

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