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GENE：ARHGEF1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ARHGEF1
FullNmae Rho guanine nucleotide exchange factor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:681
EnsembleID ENSG00000076928
Uniprot Q92888

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ARHGEF1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ARHGEF1 GO:0001664,GO:0003723,GO:0005085,GO:0005085,GO:0005096,GO:0005515,GO:0005737,GO:0005829,GO:0005829,GO:0005886,GO:0007186,GO:0007266,GO:0051056

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ARHGEF1 hsa:9138 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
ARHGEF1 hsa:9138 path:hsa04611 Platelet activation - Homo sapiens (human)
ARHGEF1 hsa:9138 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
ARHGEF1 hsa:9138 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
ARHGEF1 hsa:9138 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
ARHGEF1 hsa:9138 path:hsa05135 Yersinia infection - Homo sapiens (human)
ARHGEF1 hsa:9138 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
ARHGEF1 hsa:9138 path:hsa05200 Pathways in cancer - Homo sapiens (human)
ARHGEF1 hsa:9138 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
ARHGEF1 hsa:9138 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ARHGEF1 CTNNAL1 17952117 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 ARHGEF1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ARHGEF1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ARHGEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ARHGEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ARHGEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ARHGEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ARHGEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ARHGEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ARHGEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ARHGEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ARHGEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 ARHGEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ARHGEF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HOXA5 ARHGEF1 17379095 trascriptional regulation,stimulation inferred by curator TFlink
HOXA9 ARHGEF1 17379095 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 ARHGEF1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00001597DC ARHGEF1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
JAK2 ARHGEF1 22135298 phosphorylation N/A PhosphoSite
ARHGEF1 GNA13 25361965 interaction type N/A PTMCode2
GNA13 ARHGEF1 25361965 interaction type N/A PTMCode2
RHOA ARHGEF1 25361965 interaction type N/A PTMCode2
ARHGEF1 RHOA 25361965 interaction type N/A PTMCode2
GNA12 ARHGEF1 25361965 interaction type N/A PTMCode2
ARHGEF1 GNA12 25361965 interaction type N/A PTMCode2
CD44 ARHGEF1 25361965 interaction type N/A PTMCode2
ARHGEF1 CD44 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SNW1 ARHGEF1 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L ARHGEF1 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SH3KBP1 ARHGEF1 25348397 N/A physical interaction ComPPI
PSMC3 ARHGEF1 25348397 N/A physical interaction ComPPI
DCUN1D1 ARHGEF1 25348397 N/A physical interaction ComPPI
CD44 ARHGEF1 12748184 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HRAS ARHGEF1 25348397 N/A physical interaction ComPPI
ARHGEF1 PRKCA 12754211 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ARHGEF1 GNA13 12681510 14525934 20300064 24234451 25348397 9641916 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
ARHGEF1 ATR 25348397 N/A physical interaction ComPPI
ARHGEF1 GNA12 20300064 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARHGEF1 PIK3CA 25348397 N/A physical interaction ComPPI
ARHGEF1 RAP1A 25348397 N/A physical interaction ComPPI
ARHGEF1 TAF10 25348397 N/A physical interaction ComPPI
ARHGEF1 MEPCE 25348397 N/A physical interaction ComPPI
ARHGEF1 SREBF2 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
ARHGEF1 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ARHGEF1 CAP2 25348397 N/A physical interaction ComPPI
ARHGEF1 CYFIP1 25348397 N/A physical interaction ComPPI
ARHGEF1 TCF4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ARHGEF1 THBS4 25348397 N/A physical interaction ComPPI
ARHGEF1 THBS3 25348397 N/A physical interaction ComPPI
ARHGEF1 CCNJL 25348397 N/A physical interaction ComPPI
ARHGEF1 SLK 25348397 N/A physical interaction ComPPI
ARHGEF1 NTRK1 25348397 N/A physical interaction ComPPI
ARHGEF1 XPO1 25348397 N/A physical interaction ComPPI
ARHGEF1 AHSA1 25348397 N/A physical interaction ComPPI
ARHGEF1 GAN 25348397 N/A physical interaction ComPPI
ARHGEF1 RHOB 19637314 24234451 25348397 physical association two hybrid ComPPI,IntAct
ARHGEF1 ANG 24234451 25348397 28777577 association anti bait coimmunoprecipitation ComPPI,IntAct
RHOC ARHGEF1 25348397 N/A physical interaction ComPPI
RHOA ARHGEF1 25348397 N/A physical interaction ComPPI
CSNK1E ARHGEF1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HSCB ARHGEF1 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
ARHGEF1 ARHGEF1 14525934 14712228 N/A experimental interaction detection HPRD
MKI67 ARHGEF1 24234451 26949251 association anti tag coimmunoprecipitation IntAct
H3-4 ARHGEF1 24234451 30021884 physical association cross-linking study IntAct
ARHGEF1 RHOA 10836144 27898060 stimulant N/A OmniPath
GNA13 ARHGEF1 12681510 14634662 27898060 9641915 9641916 stimulant N/A OmniPath
ARHGEF1 GNA13 12681510 14634662 27898060 9641915 9641916 inhibition,stimulant N/A OmniPath
JAK2 ARHGEF1 20098430 27898060 stimulant N/A OmniPath
ARHGEF1 ARHGAP1 27898060 8810315 stimulant N/A OmniPath
GNA12 ARHGEF1 14634662 27898060 9641916 stimulant N/A OmniPath

Visualization










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