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GENE：DOCK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DOCK2
FullNmae dedicator of cytokinesis 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2988
EnsembleID ENSG00000134516
Uniprot Q92608

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DOCK2 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DOCK2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DOCK2 GO:0001766,GO:0001768,GO:0001771,GO:0002277,GO:0005085,GO:0005085,GO:0005085,GO:0005096,GO:0005515,GO:0005576,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0006935,GO:0007264,GO:0007520,GO:0016020,GO:0016477,GO:0030036,GO:0031267,GO:0035580,GO:0042608,GO:0044351,GO:0045059,GO:0045060,GO:0046633,GO:0050766,GO:0051056,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DOCK2 hsa:1794 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TRIM23 DOCK2 23180781 25416956 physical association two hybrid InnateDB
ELMO1 DOCK2 12829596 14737186 23109003 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR DOCK2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 DOCK2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 DOCK2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 DOCK2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 DOCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DOCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 DOCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 DOCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DOCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DOCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DOCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF DOCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 DOCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 DOCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 DOCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 DOCK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
HNRNPK DOCK2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRTAP9-2 DOCK2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
SNW1 DOCK2 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HOXA1 DOCK2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PLEKHF2 DOCK2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRTAP5-9 DOCK2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRTAP10-1 DOCK2 25348397 N/A physical interaction ComPPI
KRTAP10-8 DOCK2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRTAP9-4 DOCK2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PAK2 DOCK2 25348397 N/A physical interaction ComPPI
KRTAP4-2 DOCK2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MCM2 DOCK2 25348397 N/A physical interaction ComPPI
KRT31 DOCK2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KHDRBS2 DOCK2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRT40 DOCK2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RAC1 DOCK2 10559471 12134158 14525934 15723800 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct
MDFI DOCK2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRTAP3-3 DOCK2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VAV1 DOCK2 12393632 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CRKL DOCK2 12393632 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
KHDRBS1 DOCK2 25348397 N/A physical interaction ComPPI
PLSCR1 DOCK2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CCNDBP1 DOCK2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CD247 DOCK2 12176041 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,proximity ligation assay ComPPI,HPRD,IntAct
ELMO1 DOCK2 25348397 N/A pull down,physical interaction,physical interaction ComPPI
TRIM23 DOCK2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
TGM1 DOCK2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FYB1 DOCK2 19798671 24234451 25348397 association tandem affinity purification ComPPI,IntAct
RAC2 DOCK2 10559471 14525934 14737186 24234451 25348397 association experimental interaction detection,pull down,physical interaction ComPPI,HPRD,IntAct
KHDRBS3 DOCK2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TERF1 DOCK2 25348397 N/A physical interaction ComPPI
CDC25B DOCK2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CALCOCO2 DOCK2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CARD10 DOCK2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MTUS2 DOCK2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
NOTCH2NLA DOCK2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
KRT34 DOCK2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRTAP9-3 DOCK2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DOCK2 KRTAP10-9 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
DOCK2 KRTAP10-3 25348397 N/A physical interaction ComPPI
DOCK2 CYSRT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DOCK2 KRTAP1-1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DOCK2 KRTAP5-7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DOCK2 KRTAP12-3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DOCK2 TENM4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DOCK2 KRTAP17-1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DOCK2 GOLGA6L9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRTAP3-1 DOCK2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRTAP10-7 DOCK2 24234451 physical association two hybrid array,two hybrid prey pooling approach IntAct

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