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GENE：HPRT1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HPRT1
FullNmae hypoxanthine phosphoribosyltransferase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5157
EnsembleID ENSG00000165704
Uniprot P00492

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HPRT1 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HPRT1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
HPRT1 GO:0000166,GO:0000287,GO:0000287,GO:0001913,GO:0001975,GO:0004422,GO:0004422,GO:0005515,GO:0005737,GO:0005829,GO:0005829,GO:0005829,GO:0006164,GO:0006166,GO:0006178,GO:0006178,GO:0007625,GO:0007626,GO:0021756,GO:0021895,GO:0021954,GO:0032263,GO:0032263,GO:0032264,GO:0032264,GO:0042417,GO:0042802,GO:0043103,GO:0044209,GO:0045964,GO:0046038,GO:0046040,GO:0046083,GO:0046100,GO:0046100,GO:0046651,GO:0048813,GO:0051289,GO:0052657,GO:0070062,GO:0071542

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HPRT1 hsa:3251 path:hsa00230 Purine metabolism - Homo sapiens (human)
HPRT1 hsa:3251 path:hsa00983 Drug metabolism - other enzymes - Homo sapiens (human)
HPRT1 hsa:3251 path:hsa01100 Metabolic pathways - Homo sapiens (human)
HPRT1 hsa:3251 path:hsa01232 Nucleotide metabolism - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GATA2 HPRT1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 HPRT1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 HPRT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HPRT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 HPRT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HPRT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HPRT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 HPRT1 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EED18 HPRT1 19696787 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS00004CD810 HPRT1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000038718E HPRT1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 HPRT1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 HPRT1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC HPRT1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB HPRT1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A HPRT1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B HPRT1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000020CEC2 HPRT1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000260A3A HPRT1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00003A8BB2 HPRT1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A HPRT1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 HPRT1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 HPRT1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000039A25B HPRT1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075B13F HPRT1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 HPRT1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE HPRT1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 HPRT1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000037B2E0 HPRT1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000319E1 HPRT1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000496C56 HPRT1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000049FAE8 HPRT1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000008F0CF HPRT1 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CUL5 HPRT1 25348397 N/A physical interaction ComPPI
EIF1B HPRT1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAF6 HPRT1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HPRT1 NTAQ1 14525934 16189514 19060904 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
HPRT1 MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HPRT1 HUS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HPRT1 FANCA 25348397 N/A physical interaction ComPPI
HPRT1 CUL3 25348397 N/A physical interaction ComPPI
HPRT1 APRT 25348397 N/A physical interaction ComPPI
HPRT1 ANXA6 25348397 N/A physical interaction ComPPI
HPRT1 EIF6 25348397 N/A physical interaction ComPPI
HPRT1 PPID 25348397 N/A physical interaction ComPPI
HPRT1 SNCA 25348397 N/A physical interaction ComPPI
HPRT1 MTAP 25348397 N/A physical interaction ComPPI
HPRT1 NME2 25348397 N/A physical interaction ComPPI
HPRT1 PTGES3 25348397 N/A physical interaction ComPPI
HPRT1 FUS 25348397 N/A physical interaction ComPPI
HPRT1 SDCBP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
HPRT1 ISCU 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
HPRT1 CUL7 25348397 N/A physical interaction ComPPI
HPRT1 EWSR1 25348397 N/A physical interaction ComPPI
HPRT1 MCM2 25348397 N/A physical interaction ComPPI
HPRT1 UBE2N 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
HPRT1 GPI 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
HPRT1 ANXA5 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
HPRT1 PA2G4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
HPRT1 DLD 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HPRT1 DNM1L 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
HPRT1 ATG5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HPRT1 GABARAPL2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HPRT1 VHL 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HPRT1 HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HPRT1 PRKAB1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HPRT1 TNFRSF14 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HPRT1 EPB41 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HPRT1 IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HPRT1 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HPRT1 GABARAP 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HPRT1 OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation ComPPI,IntAct
HPRT1 NFKB1 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
HPRT1 JUN 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
HPRT1 SPG21 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HPRT1 GNMT 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HPRT1 KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
SHARPIN HPRT1 24234451 30561431 association virotrap IntAct

Visualization










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