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GENE：LIMK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LIMK2
FullNmae LIM domain kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6614
EnsembleID ENSG00000182541
Uniprot P53671

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LIMK2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LIMK2 GO:0001934,GO:0004674,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0005801,GO:0005813,GO:0006468,GO:0007283,GO:0016310,GO:0030036,GO:0030953,GO:0046872,GO:0048471,GO:0051650,GO:0060322,GO:0061303,GO:0072686,GO:0106310,GO:1900182,GO:1902018

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LIMK2 hsa:3985 path:hsa04360 Axon guidance - Homo sapiens (human)
LIMK2 hsa:3985 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
LIMK2 hsa:3985 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
LIMK2 hsa:3985 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CDC42BPA LIMK2 10461188 10559936 10613909 11340065 11413130 11950587 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
E2F4 LIMK2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 LIMK2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 LIMK2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 LIMK2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 LIMK2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 LIMK2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 LIMK2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C LIMK2 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 LIMK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA LIMK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LIMK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 LIMK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 LIMK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS LIMK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A LIMK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF LIMK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 LIMK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 LIMK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 LIMK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
PRKCD LIMK2 22135298 phosphorylation N/A PhosphoSite
AURKA LIMK2 22135298 phosphorylation N/A PhosphoSite
LIMK2 CFL1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
LIMK2 DSTN 22135298 phosphorylation N/A PhosphoSite
ROCK1 LIMK2 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
ROCK2 LIMK2 22135298 phosphorylation N/A PhosphoSite
LIMK2 PARD3 25361965 interaction type N/A PTMCode2
PARD3 LIMK2 25361965 interaction type N/A PTMCode2
LIMK2 ROCK1 25361965 interaction type N/A PTMCode2
CFL1 LIMK2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CFL1 LIMK2 25348397 N/A physical interaction,in vitro,in vivo ComPPI
EMD LIMK2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LMNA LIMK2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ROCK1 LIMK2 25348397 N/A physical interaction,in vitro,in vivo ComPPI
HSP90AB1 LIMK2 22939624 24234451 25348397 physical association anti tag coimmunoprecipitation,luminescence based mammalian interactome mapping ComPPI,IntAct
NOTCH1 LIMK2 23022380 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
UNC119 LIMK2 25348397 N/A physical interaction ComPPI
UBB LIMK2 25348397 N/A physical interaction ComPPI
HSP90AA1 LIMK2 25348397 N/A physical interaction ComPPI
HSP90B1 LIMK2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TUBA4A LIMK2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PKHD1 LIMK2 25348397 N/A in vitro,in vivo ComPPI
PARD3 LIMK2 17053785 24234451 25348397 physical association anti bait coimmunoprecipitation,in vitro,in vivo ComPPI,IntAct
ATP1A1 LIMK2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MBP LIMK2 25348397 N/A physical interaction ComPPI
TTC1 LIMK2 25348397 N/A physical interaction ComPPI
HSPB1 LIMK2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIMK1 LIMK2 25348397 N/A physical interaction,in vitro,in vivo ComPPI
HIPK3 LIMK2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDC37 LIMK2 24234451 25036637 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
CDK4 LIMK2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIMK2 CDC42BPA 25348397 N/A in vitro ComPPI
LIMK2 GSN 25348397 N/A in vitro ComPPI
LIMK2 H1-1 25348397 N/A physical interaction ComPPI
LIMK2 HSP90AA2P 25348397 N/A physical interaction ComPPI
LIMK2 BAG2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIMK2 DNAJA1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIMK2 DNAJA2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIMK2 EEF2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIMK2 FKBP5 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIMK2 RCN1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIMK2 RCN2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIMK2 RUVBL2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIMK2 SLC25A1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIMK2 SLC25A13 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIMK2 SLC25A22 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIMK2 ATP5MK 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LIMK2 HNRNPLL 25348397 N/A physical interaction ComPPI
LIMK2 SLC18A1 25348397 N/A physical interaction ComPPI
LIMK2 TRIM35 25348397 N/A physical interaction ComPPI
CALU LIMK2 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ATP5F1E LIMK2 24234451 30021884 physical association cross-linking study IntAct
PRKCD LIMK2 15923181 16820362 27898060 inhibition N/A OmniPath
ROCK1 LIMK2 10652353 11018042 11340065 22492986 27898060 stimulant N/A OmniPath
LIMK2 CFL1 10613909 11171090 11340065 11418599 11925442 18491316 18578522 18669648 18702456 19413330 19651622 20058876 20068231 27898060 8079118 9655398 inhibition,stimulant N/A OmniPath
CDC42BPA LIMK2 11018042 11171090 11340065 27898060 stimulant N/A OmniPath
LIMK2 DSTN 27898060 7615564 N/A N/A OmniPath

Visualization










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