Gene Information gene info

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GENE：MLH3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MLH3
FullNmae mutL homolog 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7128
EnsembleID ENSG00000119684
Uniprot Q9UHC1

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MLH3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MLH3 GO:0000795,GO:0001673,GO:0003682,GO:0003696,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005712,GO:0006298,GO:0006298,GO:0007130,GO:0007131,GO:0007140,GO:0007144,GO:0008104,GO:0016887,GO:0019237,GO:0030983,GO:0032300,GO:0140664

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MLH3 hsa:27030 path:hsa03430 Mismatch repair - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR MLH3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
HIF1A MLH3 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
MYCN MLH3 16093321 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 MLH3 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP73 MLH3 19558638 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 MLH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MLH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MLH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MLH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MLH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 MLH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MLH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 MLH3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001C3AC1 MLH3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 MLH3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE MLH3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016C318 MLH3 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
FBP1 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
ANP32B MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
TGFB1 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SMAD1 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
HRAS MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
AR MLH3 25348397 N/A physical interaction ComPPI
SFRP2 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SEC61B MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MAP2K1 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MYC MLH3 21150319 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PPP2CB MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
ZNF510 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
XPA MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MSH4 MLH3 12095912 25348397 27898060 N/A physical interaction ComPPI,OmniPath
DVL1 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
FANCC MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
ZDHHC17 MLH3 25348397 N/A physical interaction ComPPI
RASA1 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
ALDOB MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CDK8 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MLH1 MLH3 25348397 N/A physical interaction ComPPI
AKT1 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
STX17 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
IGFBP3 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
FRAT2 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SHMT2 MLH3 25348397 N/A physical interaction ComPPI
BAAT MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
TDRD7 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
TMOD1 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
LEF1 MLH3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MLH3 FAN1 25348397 N/A physical interaction ComPPI
MLH3 AOPEP 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MLH3 HEMGN 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MLH3 TBC1D2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct

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