GENE：MYH6
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MYH6 |
| FullNmae | myosin heavy chain 6 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:7576 |
| EnsembleID | ENSG00000197616 |
| Uniprot | P13533 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MYH6 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MYH6 | GO:0000146,GO:0000146,GO:0000146,GO:0000146,GO:0001701,GO:0001725,GO:0002026,GO:0002026,GO:0002027,GO:0005516,GO:0005524,GO:0005737,GO:0005829,GO:0005859,GO:0006936,GO:0006941,GO:0006941,GO:0007512,GO:0007512,GO:0007522,GO:0008016,GO:0008217,GO:0014898,GO:0016459,GO:0016460,GO:0017018,GO:0019901,GO:0030016,GO:0030017,GO:0030018,GO:0030049,GO:0030049,GO:0030049,GO:0030239,GO:0032982,GO:0043462,GO:0045214,GO:0045214,GO:0046034,GO:0051015,GO:0055009,GO:0055010,GO:0055013,GO:0060048,GO:0060048,GO:0060420 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| MYH6 | hsa:4624 | path:hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| MYH6 | hsa:4624 | path:hsa04260 | Cardiac muscle contraction - Homo sapiens (human) |
| MYH6 | hsa:4624 | path:hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| MYH6 | hsa:4624 | path:hsa04814 | Motor proteins - Homo sapiens (human) |
| MYH6 | hsa:4624 | path:hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| MYH6 | hsa:4624 | path:hsa05410 | Hypertrophic cardiomyopathy - Homo sapiens (human) |
| MYH6 | hsa:4624 | path:hsa05414 | Dilated cardiomyopathy - Homo sapiens (human) |
| MYH6 | hsa:4624 | path:hsa05416 | Viral myocarditis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| YBX1 | MYH6 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TEF | MYH6 | 15933209 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SRF | MYH6 | 15933209 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ELK3 | MYH6 | 12933792 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JARID2 | MYH6 | 18805276 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TBX5 | MYH6 | 15735645 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| AR | MYH6 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | MYH6 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RARA | MYH6 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TMSB4X | MYH6 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BAG3 | MYH6 | 25348397 | N/A | physical interaction | ComPPI |
| MCM2 | MYH6 | 25348397 | N/A | physical interaction | ComPPI |
| OPTN | MYH6 | 25348397 | N/A | physical interaction | ComPPI |
| HIF1A | MYH6 | 25348397 | N/A | physical interaction | ComPPI |
| MYBBP1A | MYH6 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TPM2 | MYH6 | 25348397 | N/A | physical interaction | ComPPI |
| PPP1CA | MYH6 | 24234451 25348397 25593058 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| CFTR | MYH6 | 25348397 | N/A | physical interaction | ComPPI |
| ACTN2 | MYH6 | 25348397 | N/A | physical interaction | ComPPI |
| TRIP11 | MYH6 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| NSF | MYH6 | 25348397 | N/A | physical interaction | ComPPI |
| MBP | MYH6 | 25348397 | N/A | physical interaction | ComPPI |
| ELOC | MYH6 | 25348397 | N/A | physical interaction | ComPPI |
| MAP2K3 | MYH6 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SORT1 | MYH6 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TMEM132A | MYH6 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| BDP1 | MYH6 | 25348397 | N/A | physical interaction | ComPPI |
| DCAF1 | MYH6 | 25348397 | N/A | physical interaction | ComPPI |
| HMGN1 | MYH6 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| TPM1 | MYH6 | 25348397 | N/A | physical interaction | ComPPI |
| HSPB2 | MYH6 | 24234451 25348397 26465331 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| FBXO31 | MYH6 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| DOCK6 | MYH6 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| USP24 | MYH6 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |