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GENE：NUMBL

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NUMBL
FullNmae NUMB like endocytic adaptor protein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8061
EnsembleID ENSG00000105245
Uniprot Q9Y6R0

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NUMBL immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NUMBL GO:0005515,GO:0005737,GO:0007399,GO:0007409,GO:0019221,GO:0019538,GO:0021670,GO:0021849,GO:0034332,GO:0050769,GO:0050769

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NUMBL hsa:9253 path:hsa04330 Notch signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NUMBL TAB2 18299187 23180781 physical association anti tag coimmunoprecipitation,two hybrid,pull down InnateDB
NUMBL ITCH 16508312 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GATA1 NUMBL 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 NUMBL 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 NUMBL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NUMBL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 NUMBL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NUMBL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NUMBL 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF NUMBL 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003380CC NUMBL 19296470 rna interference,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00003380CC NUMBL 19296470 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00003E226A NUMBL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002F0130 NUMBL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000170D8B NUMBL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000010BD8D NUMBL 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004CCDA3 NUMBL 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000048F59D NUMBL 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 NUMBL 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D1FC NUMBL 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D15B NUMBL 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SPSB3 NUMBL 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BHLHE40 NUMBL 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TRAF6 NUMBL 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
YWHAG NUMBL 14525934 15324660 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ATXN1 NUMBL 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
KBTBD7 NUMBL 25348397 N/A physical interaction ComPPI
SLC1A1 NUMBL 25348397 N/A physical interaction ComPPI
CBY1 NUMBL 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NOTCH1 NUMBL 14525934 25348397 9169836 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
PSMA3 NUMBL 21988832 24234451 25348397 colocalization,physical association two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
SIAH1 NUMBL 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ACTN1 NUMBL 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDH1 NUMBL 25348397 N/A physical interaction ComPPI
HNRNPL NUMBL 25348397 N/A physical interaction ComPPI
RAB3IP NUMBL 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
XPO1 NUMBL 25348397 N/A physical interaction ComPPI
EPS15 NUMBL 14525934 25348397 9303539 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
EGFR NUMBL 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
TRAF5 NUMBL 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RBFOX1 NUMBL 14525934 16713569 24234451 25348397 physical association two hybrid,pull down,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
RIPK1 NUMBL 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAGED1 NUMBL 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TAB2 NUMBL 14525934 18299187 21988832 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
TGOLN2 NUMBL 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
LNX1 NUMBL 25348397 N/A physical interaction ComPPI
NUMBL GRIP1 25348397 N/A physical interaction ComPPI
NUMBL ESRP2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NUMBL TMC5 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NUMBL GAA 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NUMBL THPO 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NUMBL GPATCH8 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NUMBL KIAA1107 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NUMBL LIMA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NUMBL GTSE1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NUMBL CTDSPL 25348397 N/A physical interaction ComPPI
NUMBL UNC5CL 25348397 N/A physical interaction ComPPI
NUMBL IKBKG 25348397 N/A physical interaction ComPPI
NUMBL EZR 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
APP NUMBL 12011466 14525934 N/A experimental interaction detection HPRD
NUMBL ITCH 16508312 27898060 stimulant N/A OmniPath
TAB2 NUMBL 18299187 21988832 27898060 N/A N/A OmniPath

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