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GENE：POLA1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol POLA1
FullNmae DNA polymerase alpha 1, catalytic subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9173
EnsembleID ENSG00000101868
Uniprot P09884

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
POLA1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
POLA1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
POLA1 GO:0000166,GO:0000731,GO:0000785,GO:0003677,GO:0003682,GO:0003682,GO:0003688,GO:0003697,GO:0003887,GO:0003887,GO:0003887,GO:0005515,GO:0005634,GO:0005635,GO:0005654,GO:0005654,GO:0005658,GO:0005658,GO:0005658,GO:0005658,GO:0005730,GO:0005829,GO:0006260,GO:0006269,GO:0006270,GO:0006271,GO:0006272,GO:0006272,GO:0006273,GO:0006273,GO:0006281,GO:0006303,GO:0008270,GO:0016363,GO:0019901,GO:0032479,GO:1902975

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
POLA1 hsa:5422 path:hsa03030 DNA replication - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
POLA1 PRIM1 15132993 26192618 9115215 interaction type N/A ACSN
POLA1 PRIM2 15132993 26192618 9115215 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
ZEN POLA1 7905482 trascriptional regulation,stimulation inferred by curator,DNase I footprinting TFlink
AR POLA1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 POLA1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 POLA1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 POLA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF POLA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 POLA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 POLA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 POLA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS POLA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF POLA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 POLA1 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 POLA1 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
RPA1 POLA1 25361965 interaction type N/A PTMCode2
POLA1 RPA1 25361965 interaction type N/A PTMCode2
POLE POLA1 25361965 interaction type N/A PTMCode2
POLA1 POLE 25361965 interaction type N/A PTMCode2
POLA1 USP3 25361965 interaction type N/A PTMCode2
USP3 POLA1 25361965 interaction type N/A PTMCode2
POLA1 POLD2 25361965 interaction type N/A PTMCode2
POLD2 POLA1 25361965 interaction type N/A PTMCode2
WDR48 POLA1 25361965 interaction type N/A PTMCode2
POLA1 WDR48 25361965 interaction type N/A PTMCode2
MCM4 POLA1 25361965 interaction type N/A PTMCode2
POLA1 MCM4 25361965 interaction type N/A PTMCode2
CDK2 POLA1 25361965 interaction type N/A PTMCode2
POLA1 CDK2 25361965 interaction type N/A PTMCode2
POLD1 POLA1 25361965 interaction type N/A PTMCode2
POLA1 POLD1 25361965 interaction type N/A PTMCode2
HELB POLA1 25361965 interaction type N/A PTMCode2
POLA1 HELB 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CIAO1 POLA1 25348397 N/A physical interaction ComPPI
PCNA POLA1 25348397 N/A physical interaction ComPPI
POLE4 POLA1 25348397 N/A physical interaction ComPPI
MCM2 POLA1 25348397 N/A physical interaction ComPPI
STN1 POLA1 25348397 N/A physical interaction ComPPI
SKAP1 POLA1 25348397 N/A physical interaction ComPPI
RB1 POLA1 14525934 25348397 27898060 9395244 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
SERPINA3 POLA1 14525934 25348397 27898060 3490907 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
POLA1 PARP1 14525934 25348397 9518481 9563011 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
POLA1 CDK2AP1 10877824 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
POLA1 RBMS1 10869558 25348397 27898060 N/A two hybrid,physical interaction,in vitro,in vivo ComPPI,OmniPath
POLA1 POLE 14525934 25348397 9563011 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
POLA1 XRCC5 12393188 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
POLA1 CDC45 10518787 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
POLA1 HELB 12181327 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
POLA1 POLA2 12138179 14525934 24234451 25348397 8223465 association affinity chromatography technology,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
POLA1 CDK2 11259605 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
POLA1 SMC1A 14525934 16438930 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
POLA1 TP53 11917009 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
POLA1 RAE1 25348397 N/A physical interaction ComPPI
POLA1 CHEK1 25348397 N/A physical interaction ComPPI
POLA1 SIRT7 25348397 N/A physical interaction ComPPI
POLA1 GINS4 25348397 N/A physical interaction ComPPI
POLA1 PRIM1 12138179 24234451 25348397 association affinity chromatography technology,physical interaction ComPPI,IntAct
POLA1 PRIM2 12138179 24234451 25348397 association affinity chromatography technology,physical interaction ComPPI,IntAct
POLA1 POLD3 25348397 N/A physical interaction ComPPI
POLA1 MCM3 25348397 N/A physical interaction ComPPI
POLA1 PURA 25348397 N/A physical interaction ComPPI
POLA1 MMS19 25348397 N/A physical interaction ComPPI
POLA1 CCNE1 25348397 N/A physical interaction ComPPI
POLA1 CCNA2 25348397 N/A physical interaction ComPPI
POLA1 PPP2CA 25348397 N/A physical interaction ComPPI
POLA1 PPP2R1B 25348397 N/A physical interaction ComPPI
POLA1 CCNB1 25348397 N/A physical interaction ComPPI
POLA1 CDK1 11259605 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
POLA1 RPA3 25348397 N/A physical interaction ComPPI
POLA1 RPA2 25348397 N/A physical interaction ComPPI
POLA1 ENO1 25348397 N/A physical interaction ComPPI
POLA1 SHMT2 25348397 N/A physical interaction ComPPI
POLA1 MOV10 25348397 N/A physical interaction ComPPI
POLA1 NXF1 25348397 N/A physical interaction ComPPI
POLA1 SOCS6 25348397 N/A physical interaction ComPPI
POLA1 TFDP3 25348397 N/A physical interaction ComPPI
POLA1 ALDH1L2 25348397 N/A physical interaction ComPPI
POLA1 RABL2A 25348397 N/A physical interaction ComPPI
POLA1 LIG1 25348397 N/A physical interaction ComPPI
POLA1 CDC6 25348397 N/A physical interaction ComPPI
POLA1 WDHD1 25348397 N/A physical interaction ComPPI
POLA1 NTRK1 25348397 N/A physical interaction ComPPI
POLA1 TRIM25 25348397 N/A physical interaction ComPPI
POLA1 CHM 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
POLA1 KDM4A 23871696 24234451 25348397 association pull down ComPPI,IntAct
POLA1 CDK8 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RPA1 POLA1 17666013 24234451 25348397 physical association coimmunoprecipitation,physical interaction ComPPI,IntAct
H3C1 POLA1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
SGG POLA1 25348397 N/A anti tag coimmunoprecipitation ComPPI
COS POLA1 15710747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid fragment pooling approach ComPPI,IntAct
MCM10 POLA1 15494305 27898060 stimulant N/A OmniPath
E2F1 POLA1 11491305 27898060 stimulant N/A OmniPath
TOPBP1 POLA1 19652550 27898060 stimulant N/A OmniPath

Visualization










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