GENE：PRUNE2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PRUNE2 |
| FullNmae | prune homolog 2 with BCH domain |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:25209 |
| EnsembleID | ENSG00000106772 |
| Uniprot | Q8WUY3 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PRUNE2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PRUNE2 | GO:0005515,GO:0005737,GO:0005829,GO:0006915,GO:0016462,GO:0046872 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | PRUNE2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | PRUNE2 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | PRUNE2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | PRUNE2 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | PRUNE2 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | PRUNE2 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | PRUNE2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PRUNE2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PRUNE2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | PRUNE2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | PRUNE2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PRUNE2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PRUNE2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PRUNE2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | PRUNE2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | PRUNE2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | PRUNE2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | PRUNE2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | PRUNE2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00002C0FCB | PRUNE2 | 20371350 21572407 25416803 | mrna cleavage,inhibition | nucleotide sequence identification,clip | TarBase |
| URS00000DDD35 | PRUNE2 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS00004E008F | PRUNE2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000013E79D | PRUNE2 | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000308E4D | PRUNE2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000021D08 | PRUNE2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000250A40 | PRUNE2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000031D186 | PRUNE2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000025EABA | PRUNE2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000052E1A6 | PRUNE2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001C11BC | PRUNE2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000315338 | PRUNE2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000031602A | PRUNE2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000251D0B | PRUNE2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000006FDD4 | PRUNE2 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| YES1 | PRUNE2 | 25348397 | N/A | physical interaction | ComPPI |
| RPS26 | PRUNE2 | 25348397 | N/A | physical interaction | ComPPI |
| LYN | PRUNE2 | 25348397 | N/A | physical interaction | ComPPI |
| SRC | PRUNE2 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPL | PRUNE2 | 25348397 | N/A | physical interaction | ComPPI |
| EWSR1 | PRUNE2 | 16189514 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach | ComPPI,IntAct |
| FYN | PRUNE2 | 25348397 | N/A | physical interaction | ComPPI |
| DYNC1H1 | PRUNE2 | 25348397 | N/A | physical interaction | ComPPI |
| RPSA | PRUNE2 | 25348397 | N/A | physical interaction | ComPPI |
| PRUNE2 | EIF2A | 25348397 | N/A | physical interaction | ComPPI |
| PRUNE2 | RPS24 | 25348397 | N/A | physical interaction | ComPPI |
| PRUNE2 | RPS5 | 25348397 | N/A | physical interaction | ComPPI |
| RCN3 | PRUNE2 | 16189514 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach | ComPPI,IntAct |
| NDUFV3 | PRUNE2 | 24234451 30021884 | physical association | cross-linking study | IntAct |