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GENE：PSMC6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PSMC6
FullNmae proteasome 26S subunit, ATPase 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9553
EnsembleID ENSG00000100519
Uniprot P62333

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PSMC6 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PSMC6 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PSMC6 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PSMC6 GO:0000502,GO:0000502,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005829,GO:0008540,GO:0016020,GO:0016234,GO:0016887,GO:0022624,GO:0030433,GO:0030674,GO:0031597,GO:0036402,GO:0036402,GO:0042802,GO:0043161,GO:0045899,GO:0070062,GO:0090261,GO:1901800

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PSMC6 hsa:5706 path:hsa03050 Proteasome - Homo sapiens (human)
PSMC6 hsa:5706 path:hsa05010 Alzheimer disease - Homo sapiens (human)
PSMC6 hsa:5706 path:hsa05012 Parkinson disease - Homo sapiens (human)
PSMC6 hsa:5706 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
PSMC6 hsa:5706 path:hsa05016 Huntington disease - Homo sapiens (human)
PSMC6 hsa:5706 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
PSMC6 hsa:5706 path:hsa05020 Prion disease - Homo sapiens (human)
PSMC6 hsa:5706 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
PSMC6 hsa:5706 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PSMC6 HSPB1 12897149 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 PSMC6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PSMC6 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PSMC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PSMC6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PSMC6 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 PSMC6 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
PSMA4 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMA4 25361965 interaction type N/A PTMCode2
PSMA6 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMA6 25361965 interaction type N/A PTMCode2
PSMC4 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMC4 25361965 interaction type N/A PTMCode2
PSMD6 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMD6 25361965 interaction type N/A PTMCode2
PSMD8 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMD8 25361965 interaction type N/A PTMCode2
USP14 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 USP14 25361965 interaction type N/A PTMCode2
PSMD1 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMD1 25361965 interaction type N/A PTMCode2
PSMC1 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMC1 25361965 interaction type N/A PTMCode2
PSMB2 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMB2 25361965 interaction type N/A PTMCode2
PAAF1 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PAAF1 25361965 interaction type N/A PTMCode2
PSMB1 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMB1 25361965 interaction type N/A PTMCode2
PSMA5 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMA5 25361965 interaction type N/A PTMCode2
PSMA1 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMA1 25361965 interaction type N/A PTMCode2
PSMD11 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMD11 25361965 interaction type N/A PTMCode2
PSMA7 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMA7 25361965 interaction type N/A PTMCode2
PSMD5 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMD5 25361965 interaction type N/A PTMCode2
PSMD14 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMD14 25361965 interaction type N/A PTMCode2
PSMB4 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMB4 25361965 interaction type N/A PTMCode2
PSMD7 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMD7 25361965 interaction type N/A PTMCode2
PSMA3 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMA3 25361965 interaction type N/A PTMCode2
PSMD10 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMD10 25361965 interaction type N/A PTMCode2
PIPSL PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PIPSL 25361965 interaction type N/A PTMCode2
PSMC3 PSMC6 25361965 interaction type N/A PTMCode2
PSMC6 PSMC3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
BYSL PSMC6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SNW1 PSMC6 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SMARCE1 PSMC6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDC5L PSMC6 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
C1ORF216 PSMC6 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
AIMP2 PSMC6 25348397 N/A physical interaction ComPPI
PSMC3 PSMC6 19490896 24234451 25348397 25416956 association,physical association anti tag coimmunoprecipitation,two hybrid,cosedimentation in solution,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PSMC6 CRK 14525934 16189514 24234451 25348397 26871637 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
PSMC6 PSMD9 14525934 16189514 19490896 21516116 24234451 25348397 25416956 association,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
PSMC6 CCDC85B 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PSMC6 PAAF1 14525934 15831487 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PSMC6 PSMD10 17353931 19490896 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC6 PSMD6 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC6 PSMD13 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC6 PSMC5 16763564 19490896 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cosedimentation in solution,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMC6 ATXN7 25348397 N/A physical interaction ComPPI
PSMC6 PSMD14 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC6 PSMD7 19490896 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,cosedimentation in solution,physical interaction ComPPI,IntAct
PSMC6 UCHL5 18922472 19490896 19615732 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC6 USP14 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC6 PMS2 25348397 N/A physical interaction ComPPI
PSMC6 PMS2CL 25348397 N/A physical interaction ComPPI
PSMC6 UBC 25348397 N/A physical interaction ComPPI
PSMC6 MDM2 25348397 N/A physical interaction ComPPI
PSMC6 MYC 17314511 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PSMC6 HDAC5 25348397 N/A physical interaction ComPPI
PSMC6 JKAMP 25348397 N/A physical interaction ComPPI
PSMC6 SIAH1 25348397 N/A physical interaction ComPPI
PSMC6 INSIG2 25348397 N/A physical interaction ComPPI
PSMC6 EIF3E 20890303 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC6 PSMD12 20890303 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC6 SEM1 25348397 N/A physical interaction ComPPI
PSMC6 SEM1 25348397 N/A physical interaction ComPPI
PSMC6 PSMC2 19490896 22901813 24234451 25348397 association,physical association anti tag coimmunoprecipitation,cosedimentation in solution,physical interaction ComPPI,IntAct
PSMC6 FKBP8 25348397 N/A physical interaction ComPPI
PSMC6 PSMD8 25348397 N/A physical interaction ComPPI
PSMC6 PSMC4 19490896 24234451 25348397 association,physical association anti tag coimmunoprecipitation,cosedimentation in solution,physical interaction ComPPI,IntAct
PSMC6 PINK1 25348397 N/A physical interaction ComPPI
PSMC6 ECPAS 25348397 N/A physical interaction ComPPI
PSMC6 PSMA2 25348397 N/A physical interaction ComPPI
PSMC6 CUL4A 25348397 N/A physical interaction ComPPI
PSMC6 CDK2 25348397 N/A physical interaction ComPPI
PSMC6 GRK5 25348397 N/A physical interaction ComPPI
PSMC6 PSMC1 19490896 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,cosedimentation in solution,physical interaction ComPPI,IntAct
PSMC6 PSMD1 19490896 24234451 25348397 physical association cosedimentation in solution,physical interaction ComPPI,IntAct
PSMC6 PSMD2 19490896 24234451 25348397 association,physical association anti tag coimmunoprecipitation,cosedimentation in solution,physical interaction ComPPI,IntAct
PSMC6 PSMD11 25348397 N/A physical interaction ComPPI
PSMC6 PSMD4 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC6 PSMD3 25348397 N/A physical interaction ComPPI
PSMC6 PSMA1 19490896 24234451 25348397 physical association cosedimentation in solution,physical interaction ComPPI,IntAct
PSMC6 PSMA6 25348397 N/A physical interaction ComPPI
PSMC6 PSMA7 25348397 N/A physical interaction ComPPI
PSMC6 PSMA5 25348397 N/A physical interaction ComPPI
PSMC6 PSMA3 25348397 N/A physical interaction ComPPI
PSMC6 PSMB1 25348397 N/A physical interaction ComPPI
PSMC6 PSMB2 25348397 N/A physical interaction ComPPI
PSMC6 PSMB3 25348397 N/A physical interaction ComPPI
PSMC6 PSMB5 25348397 N/A physical interaction ComPPI
PSMC6 PSMA4 25348397 N/A physical interaction ComPPI
PSMC6 PSMB6 25348397 N/A physical interaction ComPPI
PSMC6 RAD23B 20890303 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
PSMC6 PSMA8 25348397 N/A physical interaction ComPPI
PSMC6 UBE2C 25348397 N/A physical interaction ComPPI
PSMC6 PPP2CA 25348397 N/A physical interaction ComPPI
PSMC6 RUVBL1 25348397 N/A physical interaction ComPPI
PSMC6 UFM1 25348397 N/A physical interaction ComPPI
PSMC6 SEPTIN2 25348397 N/A physical interaction ComPPI
PSMC6 STIP1 25348397 N/A physical interaction ComPPI
PSMC6 CCT2 25348397 N/A physical interaction ComPPI
PSMC6 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
PSMC6 NOS2 25348397 N/A physical interaction ComPPI
PSMC6 PRKN 25348397 N/A physical interaction ComPPI
PSMC6 CDK20 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PSMC6 CILK1 25348397 N/A physical interaction ComPPI
PSMC6 FBXO6 25348397 N/A physical interaction ComPPI
PSMC6 ADRM1 24234451 24811749 25348397 association physical interaction,blue native page ComPPI,IntAct
PSMC6 ABCF1 25348397 N/A physical interaction ComPPI
PSMC6 AIMP1 25348397 N/A physical interaction ComPPI
PSMC6 DYNC1LI1 25348397 N/A physical interaction ComPPI
PSMC6 QARS1 25348397 N/A physical interaction ComPPI
PSMC6 RPS12 25348397 N/A physical interaction ComPPI
PSMC6 RPS15A 25348397 N/A physical interaction ComPPI
PSMC6 RPS21 25348397 N/A physical interaction ComPPI
PSMC6 RPS8 25348397 N/A physical interaction ComPPI
PSMC6 TXNL1 25348397 N/A physical interaction ComPPI
PSMC6 UBR4 25348397 N/A physical interaction ComPPI
PSMC6 STAU1 25348397 N/A physical interaction ComPPI
PSMC6 HUWE1 25348397 N/A physical interaction ComPPI
PSMC6 SDCBP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PSMC6 CYB5R2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PSMC6 CCDC146 25348397 N/A physical interaction ComPPI
PSMC6 SIRT6 25348397 N/A physical interaction ComPPI
PSMC6 ZFAND2B 25348397 N/A physical interaction ComPPI
PSMC6 PSMB7 25348397 N/A physical interaction ComPPI
PSMC6 CCDC74B 25348397 N/A physical interaction ComPPI
PSMC6 CCDC92 25348397 N/A physical interaction ComPPI
PSMC6 PSMB9 25348397 N/A physical interaction ComPPI
PSMC6 AMBRA1 25348397 N/A physical interaction ComPPI
PSMC6 ACACA 25348397 N/A physical interaction ComPPI
PSMC6 BASP1 25348397 N/A physical interaction ComPPI
PSMC6 DNAJA4 25348397 N/A physical interaction ComPPI
PSMC6 EEF1A1 25348397 N/A physical interaction ComPPI
PSMC6 EEF1A1P5 25348397 N/A physical interaction ComPPI
PSMC6 MTCH1 25348397 N/A physical interaction ComPPI
PSMC6 PSMB8 25348397 N/A physical interaction ComPPI
PSMC6 CAD 25348397 N/A physical interaction ComPPI
PSMC6 DNAJA1 25348397 N/A physical interaction ComPPI
PSMC6 PSMD5 19490896 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC6 RCC2 25348397 N/A physical interaction ComPPI
PSMC6 RFC2 25348397 N/A physical interaction ComPPI
PSMC6 SEC61A1 25348397 N/A physical interaction ComPPI
PSMC6 NTRK1 25348397 N/A physical interaction ComPPI
PSMC6 EWSR1 25348397 N/A physical interaction ComPPI
PSMC6 TMEM67 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PSMC6 CRY1 25348397 N/A physical interaction ComPPI
PSMC6 MID1 25348397 N/A physical interaction ComPPI
PSMC6 PTPN2 25348397 N/A physical interaction ComPPI
PSMC6 UBLCP1 25348397 N/A physical interaction ComPPI
PSMC6 INTU 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PSMC6 CYLD 25348397 N/A physical interaction ComPPI
PSMC6 DLD 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PSMC6 DNM1L 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PSMC6 HSD17B10 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PSMC6 SOD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
PSMC6 BRCA1 25348397 N/A physical interaction ComPPI
PSMC6 YAP1 25348397 N/A physical interaction ComPPI
PSMC6 CFTR 25348397 N/A physical interaction ComPPI
PSMC6 KEAP1 25348397 N/A physical interaction ComPPI
PSMC6 PSME4 18845680 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PSMC6 TRAF6 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
PSMC6 FTSJ1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMC6 IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMC6 HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PSMC6 VCAM1 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
PSMC6 ASXL1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
PSMC6 BAP1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
PSMC6 L3MBTL1 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
PSMC6 YBX1 23986595 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
PSMC6 LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
PSMC6 MAPK6 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
PSMC6 PPP1R15A 24234451 25348397 29109149 association anti tag coimmunoprecipitation ComPPI,IntAct
PSMC6 ESR2 24234451 25348397 25604459 association tandem affinity purification ComPPI,IntAct
PSMC6 JUN 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
PSMC6 SEC14L5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMC6 CDC37 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMC6 GTF2A1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMC6 CRKL 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMC6 DDIT4L 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMC6 PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
PSMB4 PSMC6 25348397 N/A physical interaction ComPPI
PSMC6 PSMC6 14525934 16501559 24234451 25416956 physical association experimental interaction detection,two hybrid array,two hybrid prey pooling approach HPRD,IntAct
METTL3 PSMC6 24234451 29507755 association anti tag coimmunoprecipitation IntAct
HSPB1 PSMC6 12897149 27898060 N/A N/A OmniPath

Visualization










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