GENE：APOA4
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | APOA4 |
| FullNmae | apolipoprotein A4 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:602 |
| EnsembleID | ENSG00000110244 |
| Uniprot | P06727 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| APOA4 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| APOA4 | GO:0002227,GO:0005319,GO:0005507,GO:0005515,GO:0005576,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005769,GO:0005788,GO:0005829,GO:0006869,GO:0006982,GO:0007159,GO:0008203,GO:0008289,GO:0009986,GO:0010898,GO:0010898,GO:0014012,GO:0016042,GO:0016209,GO:0019430,GO:0030300,GO:0031210,GO:0031210,GO:0032374,GO:0033344,GO:0033344,GO:0033700,GO:0033700,GO:0034014,GO:0034361,GO:0034364,GO:0034364,GO:0034371,GO:0034372,GO:0034372,GO:0034375,GO:0034378,GO:0034445,GO:0035634,GO:0042157,GO:0042627,GO:0042627,GO:0042632,GO:0042632,GO:0042744,GO:0042802,GO:0042803,GO:0043691,GO:0043691,GO:0045202,GO:0045723,GO:0045723,GO:0046470,GO:0046470,GO:0051006,GO:0051006,GO:0055088,GO:0060228,GO:0060228,GO:0062023,GO:0065005,GO:0070062,GO:0070328,GO:0072562,GO:0120009,GO:0120020,GO:1905920 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| APOA4 | hsa:337 | path:hsa04975 | Fat digestion and absorption - Homo sapiens (human) |
| APOA4 | hsa:337 | path:hsa04977 | Vitamin digestion and absorption - Homo sapiens (human) |
| APOA4 | hsa:337 | path:hsa04979 | Cholesterol metabolism - Homo sapiens (human) |
| APOA4 | hsa:337 | path:hsa05417 | Lipid and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F1 | APOA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | APOA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | APOA4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PPARA | APOA4 | 19433068 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| APOA4 | ALB | 15174051 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| APOA4 | SNX27 | 25348397 | N/A | physical interaction | ComPPI |
| APOA4 | NR1D1 | 24234451 24311788 25348397 27898060 | colocalization,physical association | anti tag coimmunoprecipitation,confocal microscopy,proximity ligation assay | ComPPI,IntAct,OmniPath |