GENE：GABRB2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | GABRB2 |
| FullNmae | gamma-aminobutyric acid type A receptor subunit beta2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:4082 |
| EnsembleID | ENSG00000145864 |
| Uniprot | P47870 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| GABRB2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| GABRB2 | GO:0004890,GO:0004890,GO:0005254,GO:0005254,GO:0005886,GO:0005886,GO:0005886,GO:0007165,GO:0007214,GO:0007214,GO:0007214,GO:0007214,GO:0007268,GO:0007268,GO:0016917,GO:0022851,GO:0030594,GO:0030659,GO:0034707,GO:0042391,GO:0043005,GO:0045202,GO:0050877,GO:0051932,GO:0051932,GO:0060078,GO:0060119,GO:0060384,GO:0070062,GO:0071420,GO:0090102,GO:0098982,GO:0099634,GO:1902476,GO:1902476,GO:1902476,GO:1902476,GO:1902711,GO:1902711,GO:1902711,GO:1902711,GO:1904315,GO:1904862 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| GABRB2 | hsa:2561 | path:hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
| GABRB2 | hsa:2561 | path:hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| GABRB2 | hsa:2561 | path:hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| GABRB2 | hsa:2561 | path:hsa04727 | GABAergic synapse - Homo sapiens (human) |
| GABRB2 | hsa:2561 | path:hsa05032 | Morphine addiction - Homo sapiens (human) |
| GABRB2 | hsa:2561 | path:hsa05033 | Nicotine addiction - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRDM14 | GABRB2 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CEBPA | GABRB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | GABRB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | GABRB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | GABRB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | GABRB2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000047A67D | GABRB2 | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000237AF9 | GABRB2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000285DCB | GABRB2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075BDA4 | GABRB2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004D84DB | GABRB2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000235862 | GABRB2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001012BC | GABRB2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000277201 | GABRB2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000013E79D | GABRB2 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000042E8CC | GABRB2 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS0000272A92 | GABRB2 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00004A6E26 | GABRB2 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CF056 | GABRB2 | 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000028DE3F | GABRB2 | 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKCB | GABRB2 | 1321150 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| GABRB2 | PPP3CA | 12574411 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| GABRB2 | UBQLN1 | 25348397 | N/A | physical interaction | ComPPI |
| GABRB2 | GABRB3 | 25348397 | N/A | physical interaction | ComPPI |
| ARFGEF2 | GABRB2 | 14525934 15198677 | N/A | two hybrid | HPRD |
| GABRA1 | GABRB2 | 24234451 29950725 | physical association | molecular sieving | IntAct |
| CAMK2A | GABRB2 | 1334482 27898060 | N/A | N/A | OmniPath |