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GENE：ARPC4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ARPC4
FullNmae actin related protein 2/3 complex subunit 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:707
EnsembleID ENSG00000241553
Uniprot P59998

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ARPC4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ARPC4 GO:0005200,GO:0005515,GO:0005634,GO:0005829,GO:0005885,GO:0005885,GO:0005885,GO:0019899,GO:0030041,GO:0030674,GO:0034314,GO:0034314,GO:0035861,GO:0042995,GO:0045010,GO:0051015,GO:0051015,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ARPC4 hsa:10093 path:hsa04144 Endocytosis - Homo sapiens (human)
ARPC4 hsa:10093 path:hsa04530 Tight junction - Homo sapiens (human)
ARPC4 hsa:10093 path:hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
ARPC4 hsa:10093 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
ARPC4 hsa:10093 path:hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)
ARPC4 hsa:10093 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
ARPC4 hsa:10093 path:hsa05131 Shigellosis - Homo sapiens (human)
ARPC4 hsa:10093 path:hsa05132 Salmonella infection - Homo sapiens (human)
ARPC4 hsa:10093 path:hsa05135 Yersinia infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GATA2 ARPC4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ZNF263 ARPC4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000007F792 ARPC4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 ARPC4 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 ARPC4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000046CDA6 ARPC4 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ARPC3 ARPC4 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
WASL ARPC4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EIF1B ARPC4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SH3GLB1 ARPC4 25348397 N/A physical interaction ComPPI
PNMA5 ARPC4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
WAS ARPC4 12769847 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
PPP1CB ARPC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KEAP1 ARPC4 25348397 N/A physical interaction ComPPI
MCM2 ARPC4 25348397 N/A physical interaction ComPPI
VBP1 ARPC4 25348397 N/A physical interaction ComPPI
PRKACB ARPC4 25348397 N/A physical interaction ComPPI
GRB2 ARPC4 12577067 24234451 25348397 association pull down ComPPI,IntAct
JUN ARPC4 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
SUMO1 ARPC4 25348397 N/A physical interaction ComPPI
FLNA ARPC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TOM1L1 ARPC4 25348397 N/A physical interaction ComPPI
PDIA6 ARPC4 25348397 N/A physical interaction ComPPI
UBE2N ARPC4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ENO1 ARPC4 25348397 N/A physical interaction ComPPI
BAG1 ARPC4 25348397 N/A physical interaction ComPPI
PFN2 ARPC4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RPA1 ARPC4 25348397 N/A physical interaction ComPPI
CLK1 ARPC4 25348397 N/A physical interaction ComPPI
NELFCD ARPC4 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
IQGAP1 ARPC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CFTR ARPC4 25348397 N/A physical interaction ComPPI
PDLIM7 ARPC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP2CA ARPC4 25348397 N/A physical interaction ComPPI
MYO18A ARPC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDHA1 ARPC4 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
XPO1 ARPC4 25348397 N/A physical interaction ComPPI
RPA3 ARPC4 25348397 N/A physical interaction ComPPI
CTTN ARPC4 25348397 N/A physical interaction ComPPI
RNF2 ARPC4 25348397 N/A physical interaction ComPPI
FUBP1 ARPC4 25348397 N/A physical interaction ComPPI
ACTR3 ARPC4 11721045 11741539 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
VCAM1 ARPC4 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
ITGA4 ARPC4 25348397 N/A physical interaction ComPPI
LPP ARPC4 25348397 N/A physical interaction ComPPI
ARPC1B ARPC4 11721045 11741539 14525934 20404198 24234451 25348397 26655834 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,molecular sieving,pull down,physical interaction,ion exchange chromatography,in vitro ComPPI,HPRD,IntAct
CDKN2AIP ARPC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRIM25 ARPC4 25348397 N/A physical interaction ComPPI
ELAVL1 ARPC4 25348397 N/A physical interaction ComPPI
METTL1 ARPC4 25348397 N/A physical interaction ComPPI
SH3GL1 ARPC4 25348397 N/A physical interaction ComPPI
SYNPO ARPC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ANLN ARPC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EIF3K ARPC4 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ACTR2 ARPC4 11721045 11741539 14525934 24234451 25348397 26496610 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
ARPC5 ARPC4 11162547 14525934 24234451 25348397 26655834 association anti tag coimmunoprecipitation,two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
NIF3L1 ARPC4 25348397 N/A physical interaction ComPPI
TPRKB ARPC4 25348397 N/A physical interaction ComPPI
MYH9 ARPC4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARPC2 ARPC4 11162547 14525934 25348397 N/A two hybrid,physical interaction,tandem affinity purification,two hybrid ComPPI,HPRD
ARPC4 ARPC5L 14525934 16169070 24234451 25348397 26655834 30021884 association,physical association anti tag coimmunoprecipitation,two hybrid,cross-linking study,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
ARPC4 RNF130 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ARPC4 ACTR3B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ARPC4 UBE2Q2 25348397 N/A physical interaction ComPPI
ARPC4 LRRK2 25348397 N/A physical interaction ComPPI
ARPC4 ARPC1A 24234451 25348397 26655834 association,physical association anti tag coimmunoprecipitation,molecular sieving,pull down,physical interaction,ion exchange chromatography ComPPI,IntAct
ARPC4 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ARPC4 FKBP10 25348397 N/A physical interaction ComPPI
ARPC4 RPRD1B 25348397 N/A physical interaction ComPPI
ARPC4 TTLL12 25348397 N/A physical interaction ComPPI
ARPC4 GRPEL1 25348397 N/A physical interaction ComPPI
ARPC4 ZPR1 25348397 N/A physical interaction ComPPI
ARPC4 STAU1 25348397 N/A physical interaction ComPPI
ARPC4 MOV10 25348397 N/A physical interaction ComPPI
ARPC4 NXF1 25348397 N/A physical interaction ComPPI
ARPC4 UNK 25348397 N/A physical interaction ComPPI
ARPC4 EFHD2 25348397 N/A physical interaction ComPPI
ARPC4 MYO1E 25348397 N/A physical interaction ComPPI
ARPC4 CAPZA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARPC4 DBN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARPC4 MYO19 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARPC4 METTL21A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DNALI1 ARPC4 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
CALU ARPC4 25348397 N/A physical interaction ComPPI

Visualization










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