GENE：KCNJ11
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | KCNJ11 |
| FullNmae | potassium inwardly rectifying channel subfamily J member 11 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6257 |
| EnsembleID | ENSG00000187486 |
| Uniprot | Q14654 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| KCNJ11 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| KCNJ11 | GO:0001508,GO:0001666,GO:0002931,GO:0003229,GO:0005249,GO:0005515,GO:0005524,GO:0005524,GO:0005886,GO:0005886,GO:0005886,GO:0006006,GO:0006915,GO:0008282,GO:0008282,GO:0008282,GO:0008282,GO:0008340,GO:0009410,GO:0015272,GO:0015272,GO:0015272,GO:0019829,GO:0030315,GO:0030506,GO:0030955,GO:0033198,GO:0034765,GO:0042391,GO:0044325,GO:0046676,GO:0050796,GO:0050796,GO:0050877,GO:0061762,GO:0071805,GO:0071805,GO:0098662,GO:0099505,GO:0099508,GO:0099508,GO:0099508,GO:1904638,GO:1990573,GO:1990573,GO:1990573 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| KCNJ11 | hsa:3767 | path:hsa04911 | Insulin secretion - Homo sapiens (human) |
| KCNJ11 | hsa:3767 | path:hsa04929 | GnRH secretion - Homo sapiens (human) |
| KCNJ11 | hsa:3767 | path:hsa04930 | Type II diabetes mellitus - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | KCNJ11 | 20019798 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | KCNJ11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | KCNJ11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | KCNJ11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | KCNJ11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | KCNJ11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | KCNJ11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | KCNJ11 | 17894829 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS000075AEA5 | KCNJ11 | 20371350 22012620 23592263 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000010BD8D | KCNJ11 | 20371350 22012620 23446348 23592263 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00002198F3 | KCNJ11 | 20371350 22012620 23446348 23592263 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000027352D | KCNJ11 | 20371350 22012620 23446348 23592263 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000366551 | KCNJ11 | 20371350 22012620 23446348 23592263 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00001F14FE | KCNJ11 | 19536157 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001D4A78 | KCNJ11 | 19536157 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EBD4B | KCNJ11 | 19536157 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000170CF4 | KCNJ11 | 19536157 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000011DF | KCNJ11 | 19536157 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000224AEA | KCNJ11 | 19536157 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003FD55 | KCNJ11 | 19536157 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| LDHA | KCNJ11 | 25348397 | N/A | physical interaction,in vivo | ComPPI |
| EXOSC8 | KCNJ11 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| YWHAB | KCNJ11 | 25348397 | N/A | physical interaction | ComPPI |
| CDH5 | KCNJ11 | 25348397 | N/A | physical interaction | ComPPI |
| KCNJ2 | KCNJ11 | 25348397 | N/A | in vitro | ComPPI |
| AP2M1 | KCNJ11 | 16902404 25348397 27898060 | N/A | in vitro | ComPPI,OmniPath |
| KCNJ8 | KCNJ11 | 25348397 | N/A | physical interaction,in vitro,in vivo | ComPPI |
| ABCC8 | KCNJ11 | 10093054 25348397 27898060 7502040 | N/A | anti bait coimmunoprecipitation,physical interaction,in vivo | ComPPI,OmniPath |
| KCNJ11 | ABCC9 | 10093054 23587463 24234451 25348397 27898060 | physical association | in vitro,proximity ligation assay | ComPPI,IntAct,OmniPath |
| KCNJ11 | MINDY2 | 25348397 | N/A | physical interaction | ComPPI |
| KCNJ11 | IL17RC | 25348397 | N/A | physical interaction | ComPPI |
| KCNJ11 | PCDHB16 | 25348397 | N/A | physical interaction | ComPPI |
| KCNJ11 | TRPM8 | 25348397 | N/A | physical interaction | ComPPI |
| KCNJ11 | PCDHAC2 | 25348397 | N/A | physical interaction | ComPPI |
| KCNJ11 | GDPD5 | 25348397 | N/A | physical interaction | ComPPI |
| KCNJ11 | SLC17A2 | 25348397 | N/A | physical interaction | ComPPI |
| KCNJ11 | ANK2 | 19805355 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation,pull down,physical interaction | ComPPI,IntAct |
| SNCA | KCNJ11 | 20858756 27898060 | N/A | N/A | OmniPath |
| CAMK2A | KCNJ11 | 23223335 27898060 | N/A | N/A | OmniPath |
| CAMK2D | KCNJ11 | 23223335 24101510 27898060 | inhibition | N/A | OmniPath |