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GENE：LAT2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LAT2
FullNmae linker for activation of T cells family member 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12749
EnsembleID ENSG00000086730
Uniprot Q9GZY6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LAT2 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
LAT2 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
LAT2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LAT2 GO:0002250,GO:0005515,GO:0005886,GO:0005886,GO:0005886,GO:0019722,GO:0019722,GO:0035556,GO:0042113,GO:0042113,GO:0042113,GO:0042169,GO:0042169,GO:0043303,GO:0045121,GO:0050853,GO:0050853,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LAT2 hsa:7462 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
LAT2 GRB2 17277102 23180781 physical association anti tag coimmunoprecipitation InnateDB
LST1 LAT2 22589543 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
LAT2 PLCG2 20005715 interaction type N/A PSP
LAT2 PLCG1 20005715 interaction type N/A PSP,SignaLink
LAT2 CBL 20005715 interaction type N/A PSP,SignaLink

Source Target Pmid Interactiontype Methods Database
SMARCA4 LAT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA LAT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LAT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 LAT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A LAT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 LAT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 LAT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR LAT2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 LAT2 19193853 25416803 mrna cleavage,inhibition array technology TarBase
URS00003E2232 LAT2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000031B6ED LAT2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A LAT2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000393C7 LAT2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000072E4C LAT2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005E58C LAT2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000334286 LAT2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001CE046 LAT2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000011DF LAT2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000224AEA LAT2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000170D8B LAT2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 LAT2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000AD002 LAT2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 LAT2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000013DD8 LAT2 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000355E82 LAT2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SYK LAT2 22135298 phosphorylation N/A PhosphoSite
KIT LAT2 22135298 phosphorylation N/A PhosphoSite
LYN LAT2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CBL LAT2 25348397 N/A in vitro,in vivo ComPPI
PLCG2 LAT2 25348397 N/A physical interaction,in vitro ComPPI
SOS1 LAT2 25348397 N/A in vitro ComPPI
GRB2 LAT2 25348397 N/A physical interaction,in vivo ComPPI
GAB1 LAT2 25348397 N/A in vitro,in vivo ComPPI
LAT2 UBQLN4 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
LAT2 PLCG1 25348397 N/A physical interaction ComPPI
LAT2 GRB2 12514734 14722116 17277102 27898060 N/A N/A OmniPath
CSNK2A1 LAT2 14722116 27898060 N/A N/A OmniPath
SYK LAT2 14722116 17993265 27898060 stimulant N/A OmniPath

Visualization










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