GENE：PIP5K1B
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PIP5K1B |
| FullNmae | phosphatidylinositol-4-phosphate 5-kinase type 1 beta |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:8995 |
| EnsembleID | ENSG00000107242 |
| Uniprot | O14986 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PIP5K1B | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PIP5K1B | GO:0000285,GO:0001931,GO:0005515,GO:0005524,GO:0005829,GO:0005886,GO:0006661,GO:0012505,GO:0016308,GO:0016308,GO:0016308,GO:0016308,GO:0016310,GO:0046854,GO:0052742,GO:0052810 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PIP5K1B | hsa:8395 | path:hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| PIP5K1B | hsa:8395 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| PIP5K1B | hsa:8395 | path:hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| PIP5K1B | hsa:8395 | path:hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| PIP5K1B | hsa:8395 | path:hsa04144 | Endocytosis - Homo sapiens (human) |
| PIP5K1B | hsa:8395 | path:hsa04510 | Focal adhesion - Homo sapiens (human) |
| PIP5K1B | hsa:8395 | path:hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| PIP5K1B | hsa:8395 | path:hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| PIP5K1B | hsa:8395 | path:hsa05135 | Yersinia infection - Homo sapiens (human) |
| PIP5K1B | hsa:8395 | path:hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA1 | PIP5K1B | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | PIP5K1B | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | PIP5K1B | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | PIP5K1B | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | PIP5K1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | PIP5K1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | PIP5K1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | PIP5K1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | PIP5K1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | PIP5K1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | PIP5K1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | PIP5K1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | PIP5K1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | PIP5K1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | PIP5K1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | PIP5K1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | PIP5K1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | PIP5K1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | PIP5K1B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SYK | PIP5K1B | 22135298 | phosphorylation | N/A | PhosphoSite |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BTK | PIP5K1B | 25348397 | N/A | in vitro,in vivo | ComPPI |
| MCRS1 | PIP5K1B | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| SPOP | PIP5K1B | 17353931 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PIP5KL1 | PIP5K1B | 25348397 | N/A | physical interaction,in vivo | ComPPI |
| PRKCA | PIP5K1B | 23909401 27898060 | inhibition | N/A | OmniPath |
| SYK | PIP5K1B | 19553680 27898060 | N/A | N/A | OmniPath |