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GENE：NCSTN

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NCSTN
FullNmae nicastrin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17091
EnsembleID ENSG00000162736
Uniprot Q92542

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NCSTN immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NCSTN GO:0000139,GO:0002262,GO:0005515,GO:0005765,GO:0005769,GO:0005783,GO:0005789,GO:0005794,GO:0005886,GO:0005886,GO:0005886,GO:0005925,GO:0006508,GO:0006509,GO:0007212,GO:0007215,GO:0007219,GO:0007220,GO:0007220,GO:0007220,GO:0007220,GO:0007220,GO:0007611,GO:0008021,GO:0010008,GO:0010950,GO:0010950,GO:0016020,GO:0016020,GO:0016020,GO:0016485,GO:0016485,GO:0016485,GO:0016485,GO:0021549,GO:0022010,GO:0030534,GO:0030674,GO:0030674,GO:0031293,GO:0031293,GO:0034205,GO:0034205,GO:0034205,GO:0035577,GO:0042098,GO:0042383,GO:0042470,GO:0042500,GO:0042734,GO:0042982,GO:0042983,GO:0042986,GO:0042987,GO:0042987,GO:0042987,GO:0042987,GO:0043085,GO:0050673,GO:0051117,GO:0051402,GO:0070062,GO:0070765,GO:0070765,GO:0070765,GO:0070765,GO:0070765,GO:0070851,GO:0071277,GO:1900271,GO:1990926

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NCSTN hsa:23385 path:hsa04330 Notch signaling pathway - Homo sapiens (human)
NCSTN hsa:23385 path:hsa05010 Alzheimer disease - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CXCR1 NCSTN 23180781 24914212 physical association experimental knowledge based InnateDB
NCSTN NCSTN 10993067 12471034 12603837 14572442 26467481 bind,up-regulates N/A Signor
NCSTN PSEN1 10993067 12032140 12471034 12603837 14572442 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
NCSTN APH1A 12297508 12471034 12857757 14572442 15189355 21071413 23331499 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
NCSTN ABL1 20005715 interaction type N/A PSP
NCSTN NPR1 20005715 interaction type N/A PSP,SignaLink
NCSTN PSEN1 20005715 interaction type N/A PSP,SignaLink
NCSTN PSEN2 20005715 interaction type N/A PSP
NCSTN DNER 20005715 interaction type N/A PSP,SignaLink
NCSTN APH1B 20005715 interaction type N/A PSP
NCSTN PSENEN 20005715 interaction type N/A PSP
NCSTN ABL1 12021275 18988627 20005715 N/A N/A SignaLink
NCSTN APH1B 20005715 20005715 N/A N/A SignaLink
NCSTN PSEN2 10993067 18988627 20005715 20005715 N/A N/A SignaLink
NCSTN PSENEN 12198112 14572442 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 NCSTN 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 NCSTN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NCSTN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NCSTN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NCSTN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 NCSTN 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D NCSTN 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000DDD35 NCSTN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004E008F NCSTN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000003FD55 NCSTN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000016D2D4 NCSTN 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AD002 NCSTN 25100943 25416803 mrna cleavage,inhibition experimental interaction detection,miRNA interference luciferase reporter assay TarBase
URS000021D7C8 NCSTN 25100943 25416803 mrna cleavage,inhibition experimental interaction detection,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
SGK1 NCSTN 22135298 phosphorylation N/A PhosphoSite
PSENEN NCSTN 25361965 interaction type N/A PTMCode2
NCSTN PSENEN 25361965 interaction type N/A PTMCode2
NOTCH1 NCSTN 25361965 interaction type N/A PTMCode2
NCSTN NOTCH1 25361965 interaction type N/A PTMCode2
APP NCSTN 25361965 interaction type N/A PTMCode2
NCSTN APP 25361965 interaction type N/A PTMCode2
NCSTN TMED10 25361965 interaction type N/A PTMCode2
TMED10 NCSTN 25361965 interaction type N/A PTMCode2
NCSTN DNER 25361965 interaction type N/A PTMCode2
DNER NCSTN 25361965 interaction type N/A PTMCode2
NCSTN APH1A 25361965 interaction type N/A PTMCode2
APH1A NCSTN 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
VASN NCSTN 18942891 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
GOLGA2 NCSTN 18201567 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
BCAS2 NCSTN 25348397 N/A physical interaction ComPPI
LGALS3 NCSTN 25348397 N/A physical interaction ComPPI
MAPK9 NCSTN 25348397 N/A physical interaction ComPPI
YES1 NCSTN 25348397 N/A physical interaction ComPPI
SAP18 NCSTN 25348397 N/A physical interaction ComPPI
RPS7 NCSTN 25348397 N/A physical interaction ComPPI
U2AF1L5 NCSTN 25348397 N/A physical interaction ComPPI
AHNAK2 NCSTN 25348397 N/A physical interaction ComPPI
RRS1 NCSTN 25348397 N/A physical interaction ComPPI
PAG1 NCSTN 25348397 N/A physical interaction ComPPI
SRC NCSTN 25348397 N/A physical interaction ComPPI
RRAS NCSTN 25348397 N/A physical interaction ComPPI
KHDRBS1 NCSTN 25348397 N/A physical interaction ComPPI
MYBBP1A NCSTN 25348397 N/A physical interaction ComPPI
SPP1 NCSTN 25348397 N/A physical interaction ComPPI
ESYT2 NCSTN 25348397 N/A physical interaction ComPPI
NTRK1 NCSTN 25348397 N/A physical interaction ComPPI
CANX NCSTN 24234451 25348397 29568061 association pull down ComPPI,IntAct
PRPF40A NCSTN 25348397 N/A physical interaction ComPPI
EPHA2 NCSTN 25348397 N/A physical interaction ComPPI
HNRNPU NCSTN 25348397 N/A physical interaction ComPPI
PTPRG NCSTN 25348397 N/A physical interaction ComPPI
EWSR1 NCSTN 25348397 N/A physical interaction ComPPI
RAP2A NCSTN 25348397 N/A physical interaction ComPPI
RCC1 NCSTN 25348397 N/A physical interaction ComPPI
SMARCB1 NCSTN 25348397 N/A physical interaction ComPPI
SRSF1 NCSTN 25348397 N/A physical interaction ComPPI
ATP1A1 NCSTN 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PSEN2 NCSTN 10993067 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
DAG1 NCSTN 18942891 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SEPTIN2 NCSTN 25348397 N/A physical interaction ComPPI
LMNB1 NCSTN 25348397 N/A physical interaction ComPPI
ALOX5 NCSTN 25348397 N/A physical interaction ComPPI
SUPT16H NCSTN 25348397 N/A physical interaction ComPPI
MMS19 NCSTN 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN APH1A 12297508 18201567 19376115 24234451 25348397 26280335 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,electron tomography,in vitro,in vivo ComPPI,IntAct
NCSTN APH1B 12297508 12857757 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NCSTN PSENEN 12198112 14525934 16641999 18201567 24234451 25348397 physical association anti bait coimmunoprecipitation,cosedimentation,cosedimentation in solution,experimental interaction detection,physical interaction,blue native page,in vitro ComPPI,HPRD,IntAct
NCSTN BACE1 12054507 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NCSTN TMED10 14525934 16641999 24234451 25348397 association,physical association anti bait coimmunoprecipitation,cosedimentation,experimental interaction detection,blue native page,in vivo ComPPI,HPRD,IntAct
NCSTN PSEN1 10993067 12603837 14525934 16641999 18201567 24234451 25348397 29611543 association,physical association anti bait coimmunoprecipitation,cosedimentation,cosedimentation in solution,experimental interaction detection,physical interaction,blue native page,in vivo ComPPI,HPRD,IntAct
NCSTN APP 10993067 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
NCSTN ELAVL1 25348397 N/A physical interaction ComPPI
NCSTN FBXO6 25348397 N/A physical interaction ComPPI
NCSTN ATP6V1B1 25348397 N/A physical interaction ComPPI
NCSTN THRAP3 25348397 N/A physical interaction ComPPI
NCSTN RAD50 25348397 N/A physical interaction ComPPI
NCSTN SRSF11 25348397 N/A physical interaction ComPPI
NCSTN SEPTIN7 25348397 N/A physical interaction ComPPI
NCSTN FTSJ3 25348397 N/A physical interaction ComPPI
NCSTN USP39 25348397 N/A physical interaction ComPPI
NCSTN UTP14A 25348397 N/A physical interaction ComPPI
NCSTN RPS11 25348397 N/A physical interaction ComPPI
NCSTN RBM25 25348397 N/A physical interaction ComPPI
NCSTN PRPF6 25348397 N/A physical interaction ComPPI
NCSTN SRSF10 25348397 N/A physical interaction ComPPI
NCSTN TRA2A 25348397 N/A physical interaction ComPPI
NCSTN TRIM55 25348397 N/A physical interaction ComPPI
NCSTN PSIP1 25348397 N/A physical interaction ComPPI
NCSTN NUMA1 25348397 N/A physical interaction ComPPI
NCSTN NOP56 25348397 N/A physical interaction ComPPI
NCSTN TOP1 25348397 N/A physical interaction ComPPI
NCSTN PHGDH 25348397 N/A physical interaction ComPPI
NCSTN SURF4 25348397 N/A physical interaction ComPPI
NCSTN TOP2B 25348397 N/A physical interaction ComPPI
NCSTN SMARCC2 25348397 N/A physical interaction ComPPI
NCSTN RFC4 25348397 N/A physical interaction ComPPI
NCSTN NOP58 25348397 N/A physical interaction ComPPI
NCSTN U2AF1 25348397 N/A physical interaction ComPPI
NCSTN NOP16 25348397 N/A physical interaction ComPPI
NCSTN SLC27A2 25348397 N/A physical interaction ComPPI
NCSTN RCC2 25348397 N/A physical interaction ComPPI
NCSTN NOP2 25348397 N/A physical interaction ComPPI
NCSTN PCDHA2 25348397 N/A physical interaction ComPPI
NCSTN TPBG 25348397 N/A physical interaction ComPPI
NCSTN GTF3C1 25348397 N/A physical interaction ComPPI
NCSTN S100A9 25348397 N/A physical interaction ComPPI
NCSTN SNRPD2 25348397 N/A physical interaction ComPPI
NCSTN SSRP1 25348397 N/A physical interaction ComPPI
NCSTN DPF2 25348397 N/A physical interaction ComPPI
NCSTN SMARCA5 25348397 N/A physical interaction ComPPI
NCSTN LAMP2 25348397 N/A physical interaction ComPPI
NCSTN SART1 25348397 N/A physical interaction ComPPI
NCSTN TRMT112 25348397 N/A physical interaction ComPPI
NCSTN WDR18 25348397 N/A physical interaction ComPPI
NCSTN RSL1D1 25348397 N/A physical interaction ComPPI
NCSTN SMU1 25348397 N/A physical interaction ComPPI
NCSTN ZC3H18 25348397 N/A physical interaction ComPPI
NCSTN RAB31 25348397 N/A physical interaction ComPPI
NCSTN SAFB 25348397 N/A physical interaction ComPPI
NCSTN TMEM14B 25348397 N/A physical interaction ComPPI
NCSTN HNRNPR 25348397 N/A physical interaction ComPPI
NCSTN ERLIN2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN GSAP 25348397 N/A physical interaction ComPPI
NCSTN ALDOA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN SLC25A5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN ATP2A2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN ATP5F1A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN BSG 25348397 N/A physical interaction ComPPI
NCSTN NDUFB5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN SLC2A1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN SLC7A5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN SLC7A5P1 25348397 N/A physical interaction ComPPI
NCSTN SLC25A12 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN TRIP13 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN TTI1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN TOMM20 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN SCAMP3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN RPP38 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN SPTLC1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN EBP 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN YIF1A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN MAGED2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN PRSS21 25348397 N/A physical interaction ComPPI
NCSTN IMMT 25348397 N/A physical interaction ComPPI
NCSTN ELL2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN PNKD 25348397 N/A physical interaction ComPPI
NCSTN TCTN3 25348397 N/A physical interaction ComPPI
NCSTN CRNKL1 25348397 N/A physical interaction ComPPI
NCSTN TRMT6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN SQOR 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN SRPRB 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN FAM111A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN WLS 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN CLPTM1L 25348397 N/A physical interaction ComPPI
NCSTN MAGT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN TIMM29 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN SFXN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN ACTA1 25348397 N/A physical interaction ComPPI
NCSTN MICAL1 25348397 N/A physical interaction ComPPI
NCSTN EEPD1 25348397 N/A physical interaction ComPPI
NCSTN NCAM1 25348397 N/A physical interaction ComPPI
NCSTN DNER 18942891 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN DSG2 18942891 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN NPR1 18942891 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN PLXDC2 18942891 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NCSTN TMED2 16641999 24234451 25348397 physical association cosedimentation,cosedimentation in solution,blue native page ComPPI,IntAct
NCSTN TGOLN2 18201567 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
NCSTN LAMP1 18201567 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
NCSTN ATP6V1A 21674799 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NCSTN NDUFA9 20515039 24234451 25348397 colocalization cosedimentation through density gradient ComPPI,IntAct
HNRNPF NCSTN 25348397 N/A physical interaction ComPPI
IK NCSTN 25348397 N/A physical interaction ComPPI
EEF1A2 NCSTN 25348397 N/A physical interaction ComPPI
RPS14 NCSTN 25348397 N/A physical interaction ComPPI
FASTKD5 NCSTN 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RRP7A NCSTN 25348397 N/A physical interaction ComPPI
NCSTN ABL1 12021275 14525934 N/A experimental interaction detection,two hybrid HPRD
UBC NCSTN 19725872 21600962 27898060 N/A N/A OmniPath
NCSTN APP 10993067 12011466 27898060 N/A N/A OmniPath
NCSTN JAG2 12551931 27898060 N/A N/A OmniPath
SGK1 NCSTN 22590650 27898060 N/A N/A OmniPath
PSEN1 NCSTN 10993067 11943765 12297508 12471034 12603837 14572442 15257293 15474363 17911105 18201567 27898060 stimulant N/A OmniPath
NCSTN PSEN1 10993067 11943765 12032140 12297508 12471034 12603837 14572442 15257293 15474363 17911105 18201567 27898060 stimulant N/A OmniPath
NCSTN PSEN2 10993067 12297508 15474363 27898060 stimulant N/A OmniPath
NCSTN APH1A 12297508 12471034 12857757 14572442 15189355 15257293 15474363 17911105 18201567 19376115 27898060 stimulant N/A OmniPath
APH1A NCSTN 12297508 12471034 12857757 14572442 15257293 15474363 17911105 18201567 19376115 27898060 stimulant N/A OmniPath
APH1B NCSTN 12297508 12857757 27898060 stimulant N/A OmniPath

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