GENE：NKD1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | NKD1 |
| FullNmae | NKD inhibitor of WNT signaling pathway 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:17045 |
| EnsembleID | ENSG00000140807 |
| Uniprot | Q969G9 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| NKD1 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| NKD1 | GO:0000159,GO:0001754,GO:0005509,GO:0005515,GO:0005737,GO:0005886,GO:0007525,GO:0016055,GO:0030165,GO:0030178,GO:0045732,GO:0090090,GO:0090090,GO:0090090,GO:0090249,GO:1901231,GO:1901233,GO:2000096 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| NKD1 | hsa:85407 | path:hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| NKD1 | hsa:85407 | path:hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | NKD1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | NKD1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | NKD1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | NKD1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CEBPA | NKD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | NKD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | NKD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | NKD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | NKD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | NKD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | NKD1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00005F1B8C | NKD1 | 20371350 22012620 23592263 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00002E628F | NKD1 | 20371350 22012620 23592263 25416803 26701625 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000016FD1A | NKD1 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000021D7C8 | NKD1 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000021D08 | NKD1 | 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000224AEA | NKD1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004CCA62 | NKD1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001F373E | NKD1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000046CDA6 | NKD1 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000040EE1D | NKD1 | 25416803 28032380 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00000EEE35 | NKD1 | 25416803 27846906 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00004B4B85 | NKD1 | 25416803 28356225 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00000EC1BE | NKD1 | 25416803 28107193 | mrna cleavage,inhibition | western blot,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS000060AABB | NKD1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00001B968D | NKD1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CF056 | NKD1 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
| URS00000753AD | NKD1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000043C1C3 | NKD1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS0000221168 | NKD1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| DVL2 | NKD1 | 25361965 | interaction type | N/A | PTMCode2 |
| NKD1 | DVL2 | 25361965 | interaction type | N/A | PTMCode2 |
| NKD1 | PPP2R1A | 25361965 | interaction type | N/A | PTMCode2 |
| PPP2R1A | NKD1 | 25361965 | interaction type | N/A | PTMCode2 |
| NKD1 | DVL1 | 25361965 | interaction type | N/A | PTMCode2 |
| DVL1 | NKD1 | 25361965 | interaction type | N/A | PTMCode2 |
| NKD1 | PPP2CA | 25361965 | interaction type | N/A | PTMCode2 |
| PPP2CA | NKD1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| KRTAP5-9 | NKD1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| KRTAP10-8 | NKD1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| KRTAP2-3 | NKD1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| PPP2R1A | NKD1 | 15687260 16567647 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| MDFI | NKD1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| PPP2CA | NKD1 | 15687260 16567647 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PPP2R3A | NKD1 | 25348397 | N/A | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction | ComPPI |
| DVL3 | NKD1 | 11274398 14525934 24234451 25348397 | physical association | two hybrid,experimental interaction detection,two hybrid array,in vivo,two hybrid prey pooling approach,two hybrid | ComPPI,HPRD,IntAct |
| NKD1 | CYSRT1 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| NKD1 | KRTAP10-9 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| NKD1 | KRTAP9-8 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| NKD1 | KRTAP12-3 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| NKD1 | KRTAP10-6 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| NKD1 | KRTAP10-7 | 24234451 | physical association | two hybrid array,two hybrid prey pooling approach | IntAct |
| NKD1 | DVL3 | 11274398 15064403 20858476 27898060 | inhibition | N/A | OmniPath |