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GENE：PAPOLA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PAPOLA
FullNmae poly(A) polymerase alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14981
EnsembleID ENSG00000090060
Uniprot P51003

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PAPOLA immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PAPOLA GO:0000287,GO:0003723,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0006378,GO:0006378,GO:0030145,GO:0031124,GO:0031440,GO:0180011,GO:1990817,GO:1990817,GO:1990817

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PAPOLA hsa:10914 path:hsa03015 mRNA surveillance pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 PAPOLA 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PAPOLA 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PAPOLA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PAPOLA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PAPOLA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PAPOLA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PAPOLA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PAPOLA 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 PAPOLA 19193853 25416803 mrna cleavage,inhibition array technology TarBase
URS00002C0FCB PAPOLA 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000DDD35 PAPOLA 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000070B1D PAPOLA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD PAPOLA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 PAPOLA 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004F2EB0 PAPOLA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000215483 PAPOLA 22100165 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS000029D793 PAPOLA 22100165 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS0000572E11 PAPOLA 22100165 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS000028D811 PAPOLA 22100165 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD002 PAPOLA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 PAPOLA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 PAPOLA 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 PAPOLA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 PAPOLA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 PAPOLA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D PAPOLA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E PAPOLA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000D6C3F PAPOLA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000009265 PAPOLA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000058863C PAPOLA 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 PAPOLA 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
NUDT21 PAPOLA 25348397 N/A physical interaction ComPPI
SNRPA PAPOLA 10742179 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
NPM1 PAPOLA 21822216 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
LMNA PAPOLA 25348397 N/A physical interaction ComPPI
PPP1CB PAPOLA 25348397 N/A physical interaction ComPPI
FIP1L1 PAPOLA 25348397 N/A physical interaction ComPPI
ZYX PAPOLA 25348397 N/A physical interaction ComPPI
REL PAPOLA 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
CREBBP PAPOLA 25348397 N/A physical interaction ComPPI
SMAD2 PAPOLA 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
HDAC3 PAPOLA 25348397 N/A physical interaction ComPPI
KPNB1 PAPOLA 25348397 N/A physical interaction ComPPI
NTRK1 PAPOLA 25348397 N/A physical interaction ComPPI
PABPC1 PAPOLA 25348397 N/A physical interaction ComPPI
PKM PAPOLA 25348397 N/A protein kinase assay ComPPI
GRK2 PAPOLA 25348397 N/A physical interaction ComPPI
HUWE1 PAPOLA 25348397 N/A physical interaction ComPPI
PAPOLA YWHAE 14517258 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
PAPOLA CPSF3 14525934 18288197 24234451 25348397 8302877 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
PAPOLA HDAC1 25348397 N/A physical interaction ComPPI
PAPOLA HDAC10 25348397 N/A physical interaction ComPPI
PAPOLA SIRT1 25348397 N/A physical interaction ComPPI
PAPOLA SIRT2 25348397 N/A physical interaction ComPPI
PAPOLA CPSF6 25348397 N/A physical interaction ComPPI
PAPOLA ELAVL1 25348397 N/A physical interaction ComPPI
PAPOLA CORO1B 25348397 N/A physical interaction ComPPI
PAPOLA CORO1C 25348397 N/A physical interaction ComPPI
PAPOLA NIBAN2 25348397 N/A physical interaction ComPPI
PAPOLA NUDC 25348397 N/A physical interaction ComPPI
PAPOLA PUF60 25348397 N/A physical interaction ComPPI
PAPOLA TARS1 25348397 N/A physical interaction ComPPI
PAPOLA YAP1 25348397 N/A physical interaction ComPPI
PAPOLA GNA11 25348397 N/A physical interaction ComPPI
PAPOLA CSTF3 25348397 N/A physical interaction ComPPI
PAPOLA HNRNPA1 25348397 N/A physical interaction ComPPI
PAPOLA CPSF2 18288197 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PAPOLA MTHFD1 25348397 N/A physical interaction ComPPI
PAPOLA MTHFD1L 25348397 N/A physical interaction ComPPI
PAPOLA PABPC3 25348397 N/A physical interaction ComPPI
PAPOLA UFD1 25348397 N/A physical interaction ComPPI
PAPOLA WDR33 25348397 N/A physical interaction ComPPI
PAPOLA SUPT5H 25348397 N/A physical interaction ComPPI
PAPOLA CIRBP 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PAPOLA RSRC1 25348397 N/A physical interaction ComPPI
PAPOLA NRAS 25348397 N/A physical interaction ComPPI
PAPOLA FGB 25348397 N/A physical interaction ComPPI
PAPOLA SYMPK 18288197 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PAPOLA PCBP2 21623344 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CSTF2 PAPOLA 25348397 N/A physical interaction ComPPI
CPSF1 PAPOLA 21102410 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FIP1L1 PAPOLA 14749727 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008BF14B PAPOLA 27087310 direct interaction,inhibition N/A NPInter
URS00008BBD1B PAPOLA 27087310 direct interaction,inhibition N/A NPInter

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