GENE：WNK4
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | WNK4 |
| FullNmae | WNK lysine deficient protein kinase 4 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:14544 |
| EnsembleID | ENSG00000126562 |
| Uniprot | Q96J92 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| WNK4 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| WNK4 | GO:0002021,GO:0003096,GO:0004672,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0005923,GO:0006468,GO:0006821,GO:0006954,GO:0007165,GO:0008104,GO:0008200,GO:0008217,GO:0010467,GO:0010766,GO:0016020,GO:0030644,GO:0031404,GO:0032991,GO:0035556,GO:0035725,GO:0035932,GO:0042116,GO:0044297,GO:0050801,GO:0055074,GO:0070294,GO:0070294,GO:0070371,GO:0070528,GO:0071466,GO:0071805,GO:0072156,GO:0090188,GO:0106310,GO:1903077,GO:1903764 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GATA1 | WNK4 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | WNK4 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CTCF | WNK4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | WNK4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | WNK4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00001C3AC1 | WNK4 | 20561597 | rna interference,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS00001C3AC1 | WNK4 | 20561597 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAPKAPK2 | WNK4 | 22135298 | phosphorylation | N/A | PhosphoSite |
| SRC | WNK4 | 22135298 | phosphorylation | N/A | PhosphoSite |
| SGK1 | WNK4 | 22135298 | phosphorylation | N/A | PhosphoSite |
| WNK4 | OXSR1 | 25361965 | interaction type | N/A | PTMCode2 |
| OXSR1 | WNK4 | 25361965 | interaction type | N/A | PTMCode2 |
| WNK4 | STK39 | 25361965 | interaction type | N/A | PTMCode2 |
| STK39 | WNK4 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| OXSR1 | WNK4 | 17721439 24234451 25348397 | N/A | surface plasmon resonance,x-ray crystallography | ComPPI,IntAct |
| CLDN2 | WNK4 | 14525934 15070779 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| HSP90AB1 | WNK4 | 22939624 24234451 25348397 | physical association | luminescence based mammalian interactome mapping | ComPPI,IntAct |
| KLHL3 | WNK4 | 23453970 23576762 23665031 23838290 23962426 24234451 24641320 25313067 25348397 26286618 26349538 26435498 27898060 | physical association | pull down,physical interaction | ComPPI,IntAct,OmniPath |
| CUL3 | WNK4 | 25348397 | N/A | physical interaction | ComPPI |
| YWHAZ | WNK4 | 20618440 24234451 25348397 | association | tandem affinity purification | ComPPI,IntAct |
| HSP90AA1 | WNK4 | 25348397 | N/A | physical interaction | ComPPI |
| YWHAQ | WNK4 | 25348397 | N/A | physical interaction | ComPPI |
| NEDD4L | WNK4 | 25348397 | N/A | physical interaction | ComPPI |
| SGK1 | WNK4 | 25348397 | N/A | physical interaction | ComPPI |
| STK39 | WNK4 | 14525934 15930150 25348397 | N/A | two hybrid,physical interaction,two hybrid | ComPPI,HPRD |
| CLDN1 | WNK4 | 14525934 15070779 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| WNK4 | SLC12A3 | 12515852 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| WNK4 | CLDN4 | 14525934 15070779 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| WNK4 | BCL6 | 16147992 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| WNK4 | AKT1 | 25348397 | N/A | physical interaction | ComPPI |
| WNK4 | HSP90AA2P | 25348397 | N/A | physical interaction | ComPPI |
| WNK4 | KLHL2 | 25348397 | N/A | physical interaction | ComPPI |
| WNK4 | ESR2 | 21182203 24234451 25348397 | association | cosedimentation through density gradient | ComPPI,IntAct |
| WNK4 | CLDN3 | 14525934 15070779 | N/A | experimental interaction detection | HPRD |
| WNK4 | TRPC3 | 21670282 27898060 | inhibition | N/A | OmniPath |
| SGK1 | WNK4 | 19706464 20525693 23054253 23673010 25805816 27898060 | stimulant | N/A | OmniPath |
| WNK4 | NEDD4L | 15328345 18669648 18691976 20525693 27898060 | N/A | N/A | OmniPath |
| WNK4 | CLDN7 | 17651736 23433123 27898060 | N/A | N/A | OmniPath |