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GENE：PAPPA

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PAPPA
FullNmae pappalysin 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8602
EnsembleID ENSG00000182752
Uniprot Q13219

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PAPPA pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PAPPA immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PAPPA GO:0004222,GO:0004222,GO:0004222,GO:0005515,GO:0005576,GO:0005576,GO:0005576,GO:0005615,GO:0006508,GO:0007166,GO:0007565,GO:0008237,GO:0008237,GO:0008270,GO:0019538,GO:0030163,GO:0032354,GO:0071548

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR PAPPA 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 PAPPA 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PAPPA 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 PAPPA 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PAPPA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PAPPA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PAPPA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PAPPA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PAPPA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PAPPA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PAPPA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PAPPA 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PAPPA N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F2 PAPPA N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 PAPPA 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00001496AE PAPPA 23821525 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000160683 PAPPA 23929716 25416803 mrna cleavage,inhibition western blot,rna immunoprecipitation,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS0000122F23 PAPPA 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 PAPPA 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB PAPPA 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 PAPPA 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 PAPPA 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000003E1A9 PAPPA 25416803 26823756 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRG2 PAPPA 25361965 interaction type N/A PTMCode2
PAPPA PRG2 25361965 interaction type N/A PTMCode2
IGFBP4 PAPPA 25361965 interaction type N/A PTMCode2
PAPPA IGFBP4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TNNI3 PAPPA 12626203 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
SKIL PAPPA 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
IGHG1 PAPPA 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SMAD2 PAPPA 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD3 PAPPA 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
PLG PAPPA 14525934 25348397 27898060 7586586 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
SMAD9 PAPPA 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PAPPA PRG2 10913121 12421832 14525934 25348397 27898060 7685339 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
PAPPA C3 14525934 25348397 27898060 6203109 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
PAPPA IGFBP4 12241545 14525934 25348397 9751498 N/A experimental interaction detection,in vitro ComPPI,HPRD
PAPPA LPA 25348397 N/A physical interaction ComPPI
PAPPA H2AX 25348397 N/A physical interaction ComPPI
PAPPA ELAVL1 25348397 N/A physical interaction ComPPI
PAPPA ANP32A 25348397 N/A physical interaction ComPPI
PAPPA ANP32E 25348397 N/A physical interaction ComPPI
PAPPA ATF7IP 14525934 15231748 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
PAPPA IGHM 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PAPPA PAPPA 10913121 14525934 N/A experimental interaction detection HPRD
PLEC PAPPA 24234451 30021884 physical association cross-linking study IntAct

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