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GENE：CAMK2D

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CAMK2D
FullNmae calcium/calmodulin dependent protein kinase II delta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1462
EnsembleID ENSG00000145349
Uniprot Q13557

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CAMK2D mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CAMK2D immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CAMK2D GO:0001558,GO:0002026,GO:0003254,GO:0004674,GO:0004683,GO:0004683,GO:0005515,GO:0005516,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0005954,GO:0006357,GO:0006468,GO:0008016,GO:0010613,GO:0010649,GO:0010666,GO:0010880,GO:0010881,GO:0010881,GO:0016020,GO:0018105,GO:0018107,GO:0019871,GO:0030666,GO:0031432,GO:0032469,GO:0033017,GO:0042383,GO:0042802,GO:0042803,GO:0043005,GO:0044325,GO:0044325,GO:0046777,GO:0055119,GO:0060314,GO:0060341,GO:0071277,GO:0086003,GO:0086091,GO:0098901,GO:0098909,GO:0106310,GO:1901844,GO:1901897,GO:1902306,GO:1902514,GO:2000650

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CAMK2D hsa:817 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04024 cAMP signaling pathway - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04114 Oocyte meiosis - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04148 Efferocytosis - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04217 Necroptosis - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04360 Axon guidance - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04713 Circadian entrainment - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04720 Long-term potentiation - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04725 Cholinergic synapse - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04728 Dopaminergic synapse - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04740 Olfactory transduction - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04911 Insulin secretion - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04916 Melanogenesis - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04922 Glucagon signaling pathway - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04934 Cushing syndrome - Homo sapiens (human)
CAMK2D hsa:817 path:hsa04971 Gastric acid secretion - Homo sapiens (human)
CAMK2D hsa:817 path:hsa05012 Parkinson disease - Homo sapiens (human)
CAMK2D hsa:817 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
CAMK2D hsa:817 path:hsa05031 Amphetamine addiction - Homo sapiens (human)
CAMK2D hsa:817 path:hsa05152 Tuberculosis - Homo sapiens (human)
CAMK2D hsa:817 path:hsa05200 Pathways in cancer - Homo sapiens (human)
CAMK2D hsa:817 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
CAMK2D hsa:817 path:hsa05214 Glioma - Homo sapiens (human)
CAMK2D hsa:817 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)
CAMK2D hsa:817 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CAMK2D SQSTM1 14702098 23180781 physical association pull down InnateDB
HNMT CAMK2D 21988832 23180781 physical association two hybrid InnateDB
SRPK1 CAMK2D 23180781 23602568 phosphorylation reaction protein kinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR CAMK2D 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 CAMK2D 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C CAMK2D 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP73 CAMK2D 21245298 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 CAMK2D 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 CAMK2D 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CAMK2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CAMK2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CAMK2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CAMK2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CAMK2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 CAMK2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CAMK2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 CAMK2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CAMK2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CAMK2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 CAMK2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CAMK2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 CAMK2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CAMK2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 CAMK2D 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00005651EE CAMK2D 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002367FA CAMK2D 25416803 25767890 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CAMK2D HDAC4 22135298 phosphorylation N/A PhosphoSite
CAMK2D TTN 22135298 phosphorylation N/A PhosphoSite
CAMK2D SCN5A 22135298 phosphorylation N/A PhosphoSite
CAMK2D KCNJ11 22135298 phosphorylation N/A PhosphoSite
CAMK2D OCLN 22135298 phosphorylation N/A PhosphoSite
CAMK2D ANKRD28 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
MAGEB4 CAMK2D 25348397 N/A physical interaction ComPPI
HSPA8 CAMK2D 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
FXR2 CAMK2D 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
DNAL4 CAMK2D 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
VIM CAMK2D 10852918 14525934 15345747 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CDKN1A CAMK2D 25348397 N/A physical interaction ComPPI
STAT1 CAMK2D 11972023 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CALM1 CAMK2D 25348397 N/A cosedimentation in solution,cosedimentation in solution,isothermal titration calorimetry,x-ray crystallography,physical interaction ComPPI
KEAP1 CAMK2D 25348397 N/A physical interaction ComPPI
HSP90AB1 CAMK2D 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
AIM2 CAMK2D 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
MOAP1 CAMK2D 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
GRB2 CAMK2D 12577067 24234451 25348397 association pull down ComPPI,IntAct
JUN CAMK2D 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
CD5 CAMK2D 14525934 25348397 9692886 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
HCFC1 CAMK2D 25348397 N/A physical interaction ComPPI
MOK CAMK2D 25348397 N/A physical interaction ComPPI
HDAC4 CAMK2D 25348397 N/A physical interaction ComPPI
SCN5A CAMK2D 22514276 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,pull down,protein kinase assay ComPPI,IntAct
RYR2 CAMK2D 20479242 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HSP90AA1 CAMK2D 25348397 N/A physical interaction ComPPI
IFNGR2 CAMK2D 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
STIP1 CAMK2D 18486612 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
TIRAP CAMK2D 25348397 N/A physical interaction ComPPI
MYC CAMK2D 21150319 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ACTN2 CAMK2D 14525934 16120608 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CAMK2G CAMK2D 20668654 24234451 25348397 N/A cosedimentation in solution,physical interaction ComPPI,IntAct
UNG CAMK2D 25348397 N/A physical interaction ComPPI
SMARCB1 CAMK2D 25348397 N/A physical interaction ComPPI
GRIN2B CAMK2D 14525934 16120608 16436603 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CAMK2D RPS18 12145273 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CAMK2D CREM 14525934 25348397 8404858 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CAMK2D CAMK2B 14525934 16185778 20668654 24234451 25348397 29426014 physical association anti tag coimmunoprecipitation,cosedimentation in solution,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
CAMK2D CAMK2A 17353931 20668654 24234451 25348397 25852190 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,cosedimentation in solution,physical interaction ComPPI,IntAct
CAMK2D CYLD 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAMK2D ARRB2 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAMK2D HSP90AA2P 25348397 N/A physical interaction ComPPI
CAMK2D WASF3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CAMK2D FAM171B 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CAMK2D HNMT 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CAMK2D RPS4X 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CAMK2D ARL2BP 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CAMK2D SPATA24 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CAMK2D SRPK1 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
CAMK2D HAUS2 25348397 N/A physical interaction ComPPI
CAMK2D CEP76 25348397 N/A physical interaction ComPPI
CAMK2D FKBP1B 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CAMK2D TNPO2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CAMK2D BANP 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CAMK2D FNDC3B 25348397 N/A physical interaction ComPPI
CAMK2D MRPL11 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CAMK2D EPHA10 25348397 N/A physical interaction ComPPI
CAMK2D TSHR 25348397 N/A physical interaction ComPPI
CAMK2D ECHS1 25348397 N/A physical interaction ComPPI
CAMK2D SCRN2 25348397 N/A physical interaction ComPPI
CAMK2D DACT2 25348397 N/A physical interaction ComPPI
CAMK2D IQCF1 25348397 N/A physical interaction ComPPI
CAMK2D WNT4 25348397 N/A physical interaction ComPPI
CAMK2D ARHGAP25 25348397 N/A physical interaction ComPPI
CAMK2D NDUFA8 25348397 N/A physical interaction ComPPI
CAMK2D CEP170 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CAMK2D NIN 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
CAMK2D RCHY1 25348397 N/A physical interaction ComPPI
CAMK2D DNAH14 25348397 N/A physical interaction ComPPI
CAMK2D BAP1 25348397 N/A physical interaction ComPPI
CAMK2D KANSL3 25348397 N/A physical interaction ComPPI
CAMK2D MRM2 25348397 N/A physical interaction ComPPI
CAMK2D PUSL1 25348397 N/A physical interaction ComPPI
CAMK2D RBM42 25348397 N/A physical interaction ComPPI
CAMK2D MTG1 25348397 N/A physical interaction ComPPI
CAMK2D CXXC1 25348397 N/A physical interaction ComPPI
CAMK2D ZBTB2 25348397 N/A physical interaction ComPPI
CAMK2D WDR76 25348397 N/A physical interaction ComPPI
CAMK2D DIDO1 25348397 N/A physical interaction ComPPI
CAMK2D SETD1A 25348397 N/A physical interaction ComPPI
CAMK2D SENP5 25348397 N/A physical interaction ComPPI
CAMK2D ELP3 25348397 N/A physical interaction ComPPI
CAMK2D NEDD1 25348397 N/A physical interaction ComPPI
CAMK2D RBPJ 25348397 N/A physical interaction ComPPI
CAMK2D LIN54 25348397 N/A physical interaction ComPPI
CAMK2D TRMT61A 25348397 N/A physical interaction ComPPI
CAMK2D PIP5K1A 25348397 N/A physical interaction ComPPI
CAMK2D MAP7 25348397 N/A physical interaction ComPPI
CAMK2D ZRANB3 25348397 N/A physical interaction ComPPI
CAMK2D BOD1L1 25348397 N/A physical interaction ComPPI
CAMK2D ZNF843 25348397 N/A physical interaction ComPPI
CAMK2D CFAP410 25348397 N/A physical interaction ComPPI
CAMK2D DTL 25348397 N/A physical interaction ComPPI
CAMK2D ALAS1 25348397 N/A physical interaction ComPPI
CAMK2D TPRN 25348397 N/A physical interaction ComPPI
CAMK2D NEK1 25348397 N/A physical interaction ComPPI
CAMK2D DPH1 25348397 N/A physical interaction ComPPI
CAMK2D OGT 25348397 N/A physical interaction ComPPI
CAMK2D TSR3 25348397 N/A physical interaction ComPPI
CAMK2D C6ORF141 25348397 N/A physical interaction ComPPI
CAMK2D THUMPD3 25348397 N/A physical interaction ComPPI
CAMK2D BRCA1 25348397 N/A physical interaction ComPPI
CAMK2D IKBKG 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
CAMK2D EIF4B 18486612 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
CAMK2D IFIH1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
TTC5 CAMK2D 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CAMK2D CAMK2D 14525934 17192257 20668654 24234451 25416956 physical association cosedimentation in solution,experimental interaction detection,x-ray crystallography,two hybrid array HPRD,IntAct
CALM2 CAMK2D 20668654 24234451 physical association cosedimentation in solution,isothermal titration calorimetry,x-ray crystallography IntAct
CAMK2D MAP3K7 12482967 27898060 N/A N/A OmniPath
CAMK2D RYR2 10830164 20056922 27898060 N/A N/A OmniPath
CAMK2D HDAC4 16767219 17179159 27898060 stimulant N/A OmniPath
CAMK2D VIM 10852918 15345747 18669648 20068231 20166139 27898060 N/A N/A OmniPath
CAMK2D CEACAM1 17546042 19909740 24302721 27898060 stimulant N/A OmniPath
CAMK2D CREM 27898060 8404858 N/A N/A OmniPath
CAMK2D SCN5A 22514276 27898060 inhibition N/A OmniPath
CAMK2D TPD52 18832449 20032513 20946871 23868405 24637012 27898060 N/A N/A OmniPath
CAMK2D KCNJ11 23223335 24101510 27898060 inhibition N/A OmniPath
CAMK2D CACNB2 20194790 27898060 stimulant N/A OmniPath
CAMK2D TTN 20149875 23220127 23764881 25637629 27898060 N/A N/A OmniPath

Visualization










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