Gene Information gene info

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GENE：IL12B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL12B
FullNmae interleukin 12B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5970
EnsembleID ENSG00000113302
Uniprot P29460

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL12B pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL12B immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IL12B GO:0001817,GO:0001916,GO:0002230,GO:0002230,GO:0002323,GO:0002827,GO:0002827,GO:0002860,GO:0002862,GO:0004896,GO:0005125,GO:0005143,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0005788,GO:0005829,GO:0008083,GO:0009897,GO:0010224,GO:0010536,GO:0016477,GO:0019221,GO:0019953,GO:0019955,GO:0030101,GO:0031906,GO:0032693,GO:0032700,GO:0032725,GO:0032729,GO:0032729,GO:0032733,GO:0032733,GO:0032735,GO:0032740,GO:0032760,GO:0032816,GO:0032816,GO:0032819,GO:0032946,GO:0034105,GO:0034393,GO:0035722,GO:0042088,GO:0042093,GO:0042098,GO:0042102,GO:0042104,GO:0042164,GO:0042509,GO:0042531,GO:0042802,GO:0042832,GO:0043235,GO:0043382,GO:0043514,GO:0044877,GO:0045519,GO:0045672,GO:0045785,GO:0046982,GO:0048662,GO:0050671,GO:0050709,GO:0050729,GO:0050829,GO:0051135,GO:0051135,GO:0051142,GO:0051607,GO:0070743,GO:0071222,GO:0071346,GO:1900747,GO:1901224,GO:1903588,GO:2000318,GO:2000330

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL12B hsa:3593 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL12B hsa:3593 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
IL12B hsa:3593 path:hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human)
IL12B hsa:3593 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
IL12B hsa:3593 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IL12B hsa:3593 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
IL12B hsa:3593 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
IL12B hsa:3593 path:hsa04940 Type I diabetes mellitus - Homo sapiens (human)
IL12B hsa:3593 path:hsa05133 Pertussis - Homo sapiens (human)
IL12B hsa:3593 path:hsa05134 Legionellosis - Homo sapiens (human)
IL12B hsa:3593 path:hsa05140 Leishmaniasis - Homo sapiens (human)
IL12B hsa:3593 path:hsa05142 Chagas disease - Homo sapiens (human)
IL12B hsa:3593 path:hsa05143 African trypanosomiasis - Homo sapiens (human)
IL12B hsa:3593 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
IL12B hsa:3593 path:hsa05146 Amoebiasis - Homo sapiens (human)
IL12B hsa:3593 path:hsa05152 Tuberculosis - Homo sapiens (human)
IL12B hsa:3593 path:hsa05162 Measles - Homo sapiens (human)
IL12B hsa:3593 path:hsa05164 Influenza A - Homo sapiens (human)
IL12B hsa:3593 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
IL12B hsa:3593 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
IL12B hsa:3593 path:hsa05200 Pathways in cancer - Homo sapiens (human)
IL12B hsa:3593 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
IL12B hsa:3593 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)
IL12B hsa:3593 path:hsa05330 Allograft rejection - Homo sapiens (human)
IL12B hsa:3593 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL12B RELB 12820969 19122653 23180781 physical association anti tag coimmunoprecipitation InnateDB
IL12B RELA 12820969 19122653 20876114 23180781 24012417 physical association anti tag coimmunoprecipitation InnateDB
IL12B IL12A 10899108 23180781 7527811 8943050 disulfide bond,physical association x-ray crystallography,comigration in non denaturing gel electrophoresis,competition binding InnateDB
IL12B IL12B 23180781 7527811 disulfide bond,physical association affinity chromatography technology,comigration in non denaturing gel electrophoresis InnateDB
IL23A IL12B 11114383 18680750 18708069 23180781 disulfide bond,physical association anti tag coimmunoprecipitation,x-ray crystallography InnateDB
IL12RB1 IL12B 23180781 7911493 8943050 physical association competition binding InnateDB
IL12B IL12RB2 23180781 8943050 physical association competition binding InnateDB
SP1 IL12B 19134014 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IL23R IL12B 12023369 23180781 physical association solid phase assay InnateDB
EP300 IL12B 15286281 23180781 physical association anti tag coimmunoprecipitation InnateDB
REL IL12B 20876114 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF5 IL12B 21240265 23180781 24532789 physical association anti tag coimmunoprecipitation InnateDB
IL12B IRF1 23180781 24012417 physical association anti tag coimmunoprecipitation InnateDB
IL12B STAT1 23180781 24012417 physical association anti tag coimmunoprecipitation InnateDB
IL12B EP300 23180781 24012417 physical association anti tag coimmunoprecipitation InnateDB
IL12B CREBBP 23180781 24012417 physical association anti tag coimmunoprecipitation InnateDB
IL12B CEBPB 23180781 24012417 physical association anti tag coimmunoprecipitation InnateDB
IL12B TBP 23180781 24012417 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR IL12B 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 IL12B 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 IL12B 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SP1 IL12B 19134014 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
FOXP3 IL12B 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS2 IL12B 10657616 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 IL12B 10657616 14688340 18690006 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 IL12B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IL12B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IL12B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 IL12B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IL12B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IL12B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 IL12B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 IL12B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 IL12B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 IL12B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EP300 IL12B 15482860 trascriptional regulation,stimulation inferred by curator TFlink
IRF1 IL12B 10657616 trascriptional regulation,stimulation inferred by curator TFlink
JUN IL12B 14688340 trascriptional regulation,stimulation inferred by curator TFlink
KLF1 IL12B 14976188 trascriptional regulation,stimulation inferred by curator TFlink
REL IL12B 10657616 trascriptional regulation,stimulation inferred by curator TFlink
RELA IL12B 10657616 14688340 15270850 18690006 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 IL12B 11254706 trascriptional regulation,stimulation inferred by curator TFlink
VDR IL12B 21310195 trascriptional regulation,stimulation inferred by curator TFlink
CEBPB IL12B N/A trascriptional regulation,stimulation inferred by curator TFlink
SP3 IL12B N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001FC26E IL12B 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00003D4175 IL12B 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
IL12B IL12RB2 25361965 interaction type N/A PTMCode2
IL12RB2 IL12B 25361965 interaction type N/A PTMCode2
IL12B FCN2 25361965 interaction type N/A PTMCode2
FCN2 IL12B 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
IL12RB1 IL12B 11114383 14525934 24234451 25348397 7527811 7843232 physical association experimental interaction detection,fluorescence-activated cell sorting,in vitro,in vivo ComPPI,HPRD,IntAct
IL12RB2 IL12B 11940489 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
IL23A IL12B 11114383 12023369 18680750 24234451 25348397 29997244 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,bioluminescence resonance energy transfer,x-ray crystallography,physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct
IL23R IL12B 12023369 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ERP44 IL12B 25348397 N/A physical interaction ComPPI
IL12B IL12A 10899108 14525934 24234451 25348397 7527811 physical association coimmunoprecipitation,experimental interaction detection,x-ray crystallography,physical interaction,comigration in non denaturing gel electrophoresis,in vitro ComPPI,HPRD,IntAct
IL12B IL12B 14525934 24234451 7527811 physical association experimental interaction detection,chromatography technology,comigration in non denaturing gel electrophoresis HPRD,IntAct
IRF5 IL12B 21240265 24532789 27898060 stimulant N/A OmniPath
IL12B IL12RB1 11086056 27898060 7527811 7843232 7911493 8943050 stimulant N/A OmniPath
IL12RB1 IL12B 27898060 7527811 7843232 7911493 8943050 N/A N/A OmniPath
IL12B IL23A 11114383 18680750 18708069 27898060 N/A N/A OmniPath
IL23A IL12B 11114383 18680750 18708069 27898060 N/A N/A OmniPath
IL12B IL23R 12023369 17587057 27898060 stimulant N/A OmniPath
IL12B IL12RB2 11086056 11940489 27898060 8943050 N/A N/A OmniPath
IL12A IL12B 10779781 10899108 27898060 7527811 8943050 stimulant N/A OmniPath

Visualization










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