Gene Information gene info

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GENE：CBLC

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CBLC
FullNmae Cbl proto-oncogene C
LocusType gene with protein product
Status Approved
HGNC_id HGNC:15961
EnsembleID ENSG00000142273
Uniprot Q9ULV8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CBLC immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CBLC GO:0001784,GO:0005154,GO:0005509,GO:0005515,GO:0005886,GO:0006511,GO:0007165,GO:0007166,GO:0007175,GO:0007175,GO:0008270,GO:0016567,GO:0017124,GO:0017124,GO:0030971,GO:0042059,GO:0043407,GO:0045121,GO:0061630,GO:0061630

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CBLC hsa:23624 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
CBLC hsa:23624 path:hsa04144 Endocytosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CBLC CD247 12415267 26192618 9671496 interaction type N/A ACSN
CBLC ZAP70 12415267 26192618 9671496 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
CRK CBLC 20005715 interaction type N/A PSP
GRB2 CBLC 20005715 interaction type N/A PSP
SPRY2 CBLC 20005715 interaction type N/A PSP
INPPL1 CBLC 1250411 15668240 20542890 inhibition N/A SignaLink
SRC CBLC 12604776 20542890 inhibition N/A SignaLink
CRK CBLC 10362357 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
CEBPA CBLC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CBLC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CBLC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CBLC 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 CBLC 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
SRC CBLC 22135298 phosphorylation N/A PhosphoSite
CBLC EGFR 25361965 interaction type N/A PTMCode2
EGFR CBLC 25361965 interaction type N/A PTMCode2
CBLC CRK 25361965 interaction type N/A PTMCode2
CRK CBLC 25361965 interaction type N/A PTMCode2
CBLC FYN 25361965 interaction type N/A PTMCode2
FYN CBLC 25361965 interaction type N/A PTMCode2
CBLC ITCH 25361965 interaction type N/A PTMCode2
ITCH CBLC 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
UBE2I CBLC 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SPRY2 CBLC 12234920 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
UBE2D1 CBLC 25348397 N/A physical interaction ComPPI
CRK CBLC 10362357 10571044 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
UBE2R2 CBLC 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CD2AP CBLC 25348397 N/A physical interaction ComPPI
LYN CBLC 10362357 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SRC CBLC 14525934 14661060 25348397 9988270 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
SHC1 CBLC 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CBLC GRB2 10086340 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CBLC ITCH 12226085 14525934 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,fluorescence microscopy,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
CBLC EGFR 10362357 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CBLC FYN 25348397 N/A physical interaction ComPPI
CBLC UBE2H 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CBLC UBE2L3 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CBLC UBE2L6 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CBLC UBE2K 25348397 N/A physical interaction ComPPI
CBLC NACAD 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CBLC SH3GL3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CBLC RET 25348397 N/A physical interaction ComPPI
CBLC ZAP70 25348397 N/A physical interaction ComPPI
CBLC MET 25348397 N/A physical interaction ComPPI
CBLC UBE2D2 25348397 N/A physical interaction ComPPI
CBLC USP2 25348397 N/A physical interaction ComPPI
CBLC USP21 25348397 N/A physical interaction ComPPI
CBLC OTUD6A 25348397 N/A physical interaction ComPPI
CBLC TGFB1I1 23145173 24831009 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CBLC TRIP6 25348397 N/A physical interaction ComPPI
CBLC BIRC2 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CBLC TRAF4 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CBLC CHFR 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CBLC TRIM46 22493164 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CBLC OXA1L 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CBLC PDLIM7 25348397 N/A physical interaction ComPPI
CBLC UBE2D3 25348397 N/A physical interaction ComPPI
CBLC UBC 25348397 N/A physical interaction ComPPI
CBLC ABI2 25348397 N/A physical interaction ComPPI
CBLC BRK1 25348397 N/A physical interaction ComPPI
CBLC NCKAP1 25348397 N/A physical interaction ComPPI
CBLC WASF2 25348397 N/A physical interaction ComPPI
CBLC LPP 25348397 N/A physical interaction ComPPI
CBLC ZNHIT2 25348397 N/A physical interaction ComPPI
CBLC CYFIP2 25348397 N/A physical interaction ComPPI
CBLC GAK 25348397 N/A physical interaction ComPPI
CBLC CYFIP1 25348397 N/A physical interaction ComPPI
CBLC MGME1 25348397 N/A physical interaction ComPPI
CBLC ABI1 20598684 24234451 25348397 N/A array technology ComPPI,IntAct
CBLC BAP1 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
WASF1 CBLC 25348397 N/A physical interaction ComPPI
CKM CBLC 25348397 N/A physical interaction ComPPI
CBLC WWP-1 12226085 24234451 physical association two hybrid IntAct
SRC CBLC 14661060 20525694 22888118 24425877 27898060 9988270 stimulant N/A OmniPath
ARHGEF7 CBLC 14505571 27898060 inhibition N/A OmniPath
INPPL1 CBLC 15668240 27898060 inhibition N/A OmniPath
LRIG1 CBLC 15282549 27898060 stimulant N/A OmniPath
CBLC LRIG1 15282549 27898060 inhibition N/A OmniPath

Visualization










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