Gene Information gene info

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GENE：IGKC

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IGKC
FullNmae immunoglobulin kappa constant
LocusType immunoglobulin gene
Status Approved
HGNC_id HGNC:5716
EnsembleID ENSG00000211592
Uniprot P01834

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IGKC immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IGKC GO:0001895,GO:0002250,GO:0002250,GO:0003823,GO:0003823,GO:0005576,GO:0005615,GO:0005615,GO:0005886,GO:0005886,GO:0006955,GO:0016064,GO:0050853,GO:0070062,GO:0071735,GO:0071735,GO:0071735,GO:0071738,GO:0071742,GO:0071745,GO:0071753,GO:0072562

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IGKC IGKC 11877257 24243840 29145629 physical association inferred by curator Reactome
IGKC SYK 10579907 10648173 16849466 18006696 18052078 18818202 21469132 24243840 29145629 7522622 7528327 7530449 7538118 7592958 8071371 8163536 8226994 8340414 8809042 8862523 8910399 9314552 enzymatic reaction,physical association inferred by curator Reactome
IGKC SOS1 11071869 11449366 11909947 12456653 19372136 21822214 24243840 29145629 9341187 9697839 9705962 enzymatic reaction,physical association inferred by curator Reactome
IGKC BLNK 11071869 11449366 11909947 12456653 19372136 21822214 29145629 9341187 9697839 9705962 physical association inferred by curator Reactome
IGKC SH3KBP1 11071869 11449366 11909947 12456653 19372136 21822214 29145629 9341187 9697839 9705962 physical association inferred by curator Reactome
IGKC CD79A 1375264 1401917 2269333 24243840 29145629 7514267 physical association inferred by curator Reactome
IGKC CD79B 1375264 1401917 2269333 24243840 29145629 7514267 physical association inferred by curator Reactome
IGKC CD22 11994425 29145629 7561031 7706301 8475064 9480991 9547345 9601638 physical association inferred by curator Reactome
IGKC IGHD 24243840 29145629 physical association inferred by curator Reactome
IGKC IGHM 24243840 29145629 physical association inferred by curator Reactome
IGKC PIK3R1 12869549 15536084 29145629 physical association inferred by curator Reactome
IGKC PTPN6 23836650 29145629 7618087 9890995 physical association inferred by curator Reactome
IGKC PLCG2 15161916 29145629 7517665 8657103 physical association inferred by curator Reactome
IGKC PLCG1 15161916 29145629 7517665 8657103 physical association inferred by curator Reactome
IGKC VAV1 16546099 29145629 8809042 8986718 physical association inferred by curator Reactome
IGKC LYN 11713268 12217391 12453414 12670955 1702903 24243840 29145629 7524079 7526393 7592958 7688784 7927516 8306975 9295361 9480991 9547345 9601638 enzymatic reaction,physical association inferred by curator Reactome
IGKC FYN 12453414 1702903 29145629 7524079 7592958 7688784 7927516 8306975 enzymatic reaction inferred by curator Reactome
IGKC BLK 12453414 1702903 29145629 7524079 7592958 7688784 7927516 8306975 enzymatic reaction inferred by curator Reactome

Source Target Pmid Interactiontype Methods Database
SMARCA4 IGKC 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IGKC 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
IGHG1 IGKC 11183784 12552112 15174051 1522589 24234451 25348397 27898060 association anti bait coimmunoprecipitation,x-ray crystallography,in vitro ComPPI,IntAct,OmniPath
CDK5RAP3 IGKC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
APOA1 IGKC 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CAV1 IGKC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CD40LG IGKC 25348397 N/A in vitro ComPPI
NFKB1 IGKC 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
IGHM IGKC 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
MLH1 IGKC 20706999 24234451 25348397 physical association two hybrid ComPPI,IntAct
ALB IGKC 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
IGKC IGHG4 1522589 24234451 25348397 N/A x-ray crystallography ComPPI,IntAct
IGKC TF 15174051 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
IGKC LRRK2 24234451 24725412 25348397 association tandem affinity purification ComPPI,IntAct
IGKC HLA-B 22020283 24234451 25348397 25480565 25740999 physical association fluorescence-activated cell sorting,surface plasmon resonance,x-ray crystallography,surface plasmon resonance array ComPPI,IntAct
TANK IGKC 24234451 30561431 association virotrap IntAct
MAPT IGKC 24234451 26402096 association anti bait coimmunoprecipitation IntAct

Visualization










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