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GENE：NME4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NME4
FullNmae NME/NM23 nucleoside diphosphate kinase 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7852
EnsembleID ENSG00000103202
Uniprot O00746

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NME4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NME4 GO:0004550,GO:0005515,GO:0005524,GO:0005739,GO:0005743,GO:0005758,GO:0005759,GO:0006183,GO:0006228,GO:0006241,GO:0006869,GO:0009116,GO:0016310,GO:0046872,GO:1901612

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NME4 hsa:4833 path:hsa00230 Purine metabolism - Homo sapiens (human)
NME4 hsa:4833 path:hsa00240 Pyrimidine metabolism - Homo sapiens (human)
NME4 hsa:4833 path:hsa00983 Drug metabolism - other enzymes - Homo sapiens (human)
NME4 hsa:4833 path:hsa01100 Metabolic pathways - Homo sapiens (human)
NME4 hsa:4833 path:hsa01232 Nucleotide metabolism - Homo sapiens (human)
NME4 hsa:4833 path:hsa01240 Biosynthesis of cofactors - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ESR1 NME4 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 NME4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 NME4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NME4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 NME4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF NME4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004E008F NME4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 NME4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE NME4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000451A1 NME4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000000B1C9 NME4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000031E12 NME4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 NME4 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
LMO4 NME4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TSSK3 NME4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CHCHD2 NME4 25348397 N/A physical interaction ComPPI
SOCS3 NME4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NME3 NME4 25348397 N/A physical interaction ComPPI
ATPAF2 NME4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NUTF2 NME4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2D NME4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BMI1 NME4 25348397 N/A physical interaction ComPPI
CYCS NME4 25348397 N/A physical interaction ComPPI
PAK5 NME4 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
CIB1 NME4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PAXIP1 NME4 25348397 N/A physical interaction ComPPI
LSM8 NME4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
POLDIP2 NME4 24234451 25348397 27499296 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRP1 NME4 25348397 N/A physical interaction ComPPI
NME1 NME4 14525934 16189514 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
C1QBP NME4 24234451 25348397 27499296 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TSFM NME4 25348397 N/A physical interaction ComPPI
HTT NME4 23275563 24234451 25348397 physical association physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct
SPG21 NME4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGB8 NME4 25348397 N/A physical interaction ComPPI
PDK1 NME4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CD79A NME4 25348397 N/A physical interaction ComPPI
MLH1 NME4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CLNK NME4 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
CIDEB NME4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PSMB1 NME4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TERF2 NME4 25348397 N/A physical interaction ComPPI
AURKAIP1 NME4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
TRIP13 NME4 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
UBL5 NME4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SHMT2 NME4 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
TIMM50 NME4 25348397 N/A physical interaction ComPPI
HSPD1 NME4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NME4 NME2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NME4 SUV39H2 23455924 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NME4 TP53 25348397 N/A physical interaction ComPPI
NME4 MOV10 25348397 N/A physical interaction ComPPI
NME4 NXF1 25348397 N/A physical interaction ComPPI
NME4 TNS4 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
NME4 GLRX5 25348397 N/A physical interaction ComPPI
NME4 NT5DC2 25348397 N/A physical interaction ComPPI
NME4 TPP1 25348397 N/A physical interaction ComPPI
NME4 VSIG4 25348397 N/A physical interaction ComPPI
NME4 POLR1C 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NME4 C1ORF109 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NME4 CCDC102B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NME4 CIB3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NME4 IDE 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
ECH1 NME4 24234451 25348397 27499296 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRMT61B NME4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GOLPH3 NME4 25348397 N/A physical interaction ComPPI

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