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GENE：POLK

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol POLK
FullNmae DNA polymerase kappa
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9183
EnsembleID ENSG00000122008
Uniprot Q9UBT6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
POLK mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
POLK immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
POLK GO:0003684,GO:0003887,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0006260,GO:0006281,GO:0006281,GO:0006297,GO:0006974,GO:0016604,GO:0034644,GO:0042276,GO:0042276,GO:0046872,GO:0090734

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
POLK hsa:51426 path:hsa03460 Fanconi anemia pathway - Homo sapiens (human)
POLK hsa:51426 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
POLK hsa:51426 path:hsa05200 Pathways in cancer - Homo sapiens (human)
POLK hsa:51426 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
POLK hsa:51426 path:hsa05210 Colorectal cancer - Homo sapiens (human)
POLK hsa:51426 path:hsa05212 Pancreatic cancer - Homo sapiens (human)
POLK hsa:51426 path:hsa05213 Endometrial cancer - Homo sapiens (human)
POLK hsa:51426 path:hsa05214 Glioma - Homo sapiens (human)
POLK hsa:51426 path:hsa05216 Thyroid cancer - Homo sapiens (human)
POLK hsa:51426 path:hsa05217 Basal cell carcinoma - Homo sapiens (human)
POLK hsa:51426 path:hsa05218 Melanoma - Homo sapiens (human)
POLK hsa:51426 path:hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
POLK hsa:51426 path:hsa05222 Small cell lung cancer - Homo sapiens (human)
POLK hsa:51426 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)
POLK hsa:51426 path:hsa05224 Breast cancer - Homo sapiens (human)
POLK hsa:51426 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
POLK hsa:51426 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PCNA POLK 11756412 11900249 12466554 12648680 12930902 14624239 14657033 14726013 15189446 15189466 15459660 15703371 16697054 17035102 17116885 17296725 17582221 17652783 17884153 18087292 18157158 18196958 18584027 18677104 18809224 18931676 19217833 19225445 19258535 19622404 19686080 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22266823 22743550 23065650 23414611 24050180 26192618 8264637 8978692 interaction type N/A ACSN
POLE POLK 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 26192618 8264637 8978692 interaction type N/A ACSN
RPA2 POLK 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 26192618 8264637 8978692 interaction type N/A ACSN
XRCC1 POLK 11756412 11900249 12648680 12930902 14624239 14726013 15189466 15459660 15703371 16697054 17116885 17296725 17582221 17652783 17884153 18087292 18196958 18584027 18677104 18809224 19258535 1974050 19772495 19793801 19809470 19847258 20211143 20227374 20478261 21282463 21376743 22021614 22743550 23414611 24050180 26192618 8264637 8978692 interaction type N/A ACSN
POLK REV1 11756412 12466554 14624239 14657033 14726013 15189446 15189466 15703371 16697054 17035102 17652783 18157158 18196958 18931676 19217833 19225445 19258535 19622404 19686080 1974050 19847258 20227374 22021614 22266823 23065650 23414611 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
AR POLK 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 POLK 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 POLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA POLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF POLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 POLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 POLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS POLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HSF1 POLK 22227292 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 POLK 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000028BB8 POLK 17612493 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
POLK REV1 25361965 interaction type N/A PTMCode2
REV1 POLK 25361965 interaction type N/A PTMCode2
POLK PCNA 25361965 interaction type N/A PTMCode2
PCNA POLK 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CD2BP2 POLK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PCNA POLK 25348397 N/A physical interaction ComPPI
MCM6 POLK 25348397 N/A physical interaction ComPPI
FIP1L1 POLK 25348397 N/A physical interaction ComPPI
PIAS1 POLK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RBM4 POLK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SPART POLK 25348397 N/A physical interaction ComPPI
XRCC1 POLK 25348397 N/A physical interaction ComPPI
WRN POLK 25348397 N/A physical interaction ComPPI
RPA1 POLK 25348397 N/A physical interaction ComPPI
MSH6 POLK 25348397 N/A physical interaction ComPPI
HNRNPL POLK 25348397 N/A physical interaction ComPPI
RAD18 POLK 25348397 N/A physical interaction ComPPI
RAD51 POLK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLD1 POLK 25348397 N/A physical interaction ComPPI
STAT6 POLK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NOLC1 POLK 25348397 N/A physical interaction ComPPI
TRAIP POLK 25348397 N/A physical interaction ComPPI
H3-3A POLK 25348397 N/A physical interaction ComPPI
MCM4 POLK 25348397 N/A physical interaction ComPPI
REV1 POLK 14525934 19170759 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
UBE2V2 POLK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
XPO7 POLK 25348397 N/A physical interaction ComPPI
TIA1 POLK 25348397 N/A physical interaction ComPPI
KLF16 POLK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KCTD5 POLK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KCTD17 POLK 25348397 N/A physical interaction ComPPI
MSH2 POLK 24038355 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PARVG POLK 25348397 N/A physical interaction ComPPI
SRA1 POLK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
APOL2 POLK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLK RPAP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLK PLXNA3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLK BHLHE41 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLK TUT7 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLK CD99L2 25348397 N/A physical interaction ComPPI
POLK PCGF5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLK MAK16 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLK SYNPO2 25348397 N/A physical interaction ComPPI
POLK SBSN 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLK DTD1 25348397 N/A physical interaction ComPPI
HSPA5 POLK 24234451 30021884 physical association cross-linking study IntAct
HSP90B1 POLK 24234451 30021884 physical association cross-linking study IntAct
LMNA POLK 24234451 30021884 physical association cross-linking study IntAct
H3-4 POLK 24234451 30021884 physical association cross-linking study IntAct
CDKN1A POLK 16678112 27898060 inhibition N/A OmniPath
CREB1 POLK 17099721 27898060 stimulant N/A OmniPath
TP53 POLK 16678112 27898060 inhibition N/A OmniPath
SP1 POLK 17099721 27898060 stimulant N/A OmniPath

Visualization










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