GENE：TMEM106B
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TMEM106B |
| FullNmae | transmembrane protein 106B |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:22407 |
| EnsembleID | ENSG00000106460 |
| Uniprot | Q9NUM4 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TMEM106B | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| TMEM106B | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| TMEM106B | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TMEM106B | GO:0003674,GO:0005515,GO:0005764,GO:0005765,GO:0005765,GO:0005768,GO:0007040,GO:0007041,GO:0007042,GO:0031902,GO:0032418,GO:0032418,GO:0048813,GO:0048813,GO:0051117,GO:0070050,GO:1900006,GO:1905146,GO:1905671 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | TMEM106B | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ETS1 | TMEM106B | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | TMEM106B | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | TMEM106B | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | TMEM106B | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | TMEM106B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | TMEM106B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | TMEM106B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | TMEM106B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | TMEM106B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | TMEM106B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | TMEM106B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | TMEM106B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | TMEM106B | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000ED600 | TMEM106B | 20215506 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000070B1D | TMEM106B | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00002152A8 | TMEM106B | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000016D2D4 | TMEM106B | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000006FDD4 | TMEM106B | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000049FAE8 | TMEM106B | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001B9F58 | TMEM106B | 24374217 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CC4BD | TMEM106B | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003BBF48 | TMEM106B | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004F2EB0 | TMEM106B | 22100165 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005ACA7C | TMEM106B | 20371350 21572407 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004F4657 | TMEM106B | 20371350 21572407 23446348 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003CC709 | TMEM106B | 20371350 21572407 23446348 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CF056 | TMEM106B | 21572407 23446348 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00004719AB | TMEM106B | 21572407 23446348 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B7E30 | TMEM106B | 21572407 23446348 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00003E2232 | TMEM106B | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000031B6ED | TMEM106B | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000018D2BE | TMEM106B | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005586D0 | TMEM106B | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032835F | TMEM106B | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003380CC | TMEM106B | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |