Gene Information gene info

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GENE：UQCRC2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol UQCRC2
FullNmae ubiquinol-cytochrome c reductase core protein 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12586
EnsembleID ENSG00000140740
Uniprot P22695

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
UQCRC2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
UQCRC2 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
UQCRC2 GO:0004222,GO:0005515,GO:0005654,GO:0005739,GO:0005739,GO:0005739,GO:0005743,GO:0005743,GO:0005750,GO:0005750,GO:0005751,GO:0006119,GO:0006122,GO:0006508,GO:0009060,GO:0045333,GO:0046872

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
UQCRC2 hsa:7385 path:hsa00190 Oxidative phosphorylation - Homo sapiens (human)
UQCRC2 hsa:7385 path:hsa01100 Metabolic pathways - Homo sapiens (human)
UQCRC2 hsa:7385 path:hsa04260 Cardiac muscle contraction - Homo sapiens (human)
UQCRC2 hsa:7385 path:hsa04714 Thermogenesis - Homo sapiens (human)
UQCRC2 hsa:7385 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
UQCRC2 hsa:7385 path:hsa05010 Alzheimer disease - Homo sapiens (human)
UQCRC2 hsa:7385 path:hsa05012 Parkinson disease - Homo sapiens (human)
UQCRC2 hsa:7385 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
UQCRC2 hsa:7385 path:hsa05016 Huntington disease - Homo sapiens (human)
UQCRC2 hsa:7385 path:hsa05020 Prion disease - Homo sapiens (human)
UQCRC2 hsa:7385 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
UQCRC2 hsa:7385 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
UQCRC2 hsa:7385 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MT-CYB UQCRC2 15807660 26192618 interaction type N/A ACSN
UQCRB UQCRC2 15807660 26192618 interaction type N/A ACSN
UQCRC2 CYC1 15807660 26192618 interaction type N/A ACSN
UQCRC2 UQCRC1 15807660 26192618 interaction type N/A ACSN
UQCRFS1 UQCRC2 15807660 26192618 interaction type N/A ACSN
UQCRH UQCRC2 15807660 26192618 interaction type N/A ACSN
UQCRQ UQCRC2 15807660 26192618 interaction type N/A ACSN
UQCRC2 NLRX1 19692591 23180781 physical association anti tag coimmunoprecipitation InnateDB
ADRB2 UQCRC2 23180781 23798571 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 UQCRC2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 UQCRC2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA UQCRC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF UQCRC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 UQCRC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 UQCRC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS UQCRC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A UQCRC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF UQCRC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 UQCRC2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC UQCRC2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000B59A2 UQCRC2 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 UQCRC2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000183BED UQCRC2 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
HNRNPK UQCRC2 25348397 N/A physical interaction ComPPI
ATP5PO UQCRC2 25348397 N/A physical interaction ComPPI
KPNA4 UQCRC2 25348397 N/A physical interaction ComPPI
CDC42 UQCRC2 25348397 N/A physical interaction ComPPI
RPN1 UQCRC2 25348397 N/A physical interaction ComPPI
ATP5F1B UQCRC2 25348397 N/A physical interaction ComPPI
TOMM22 UQCRC2 25348397 N/A physical interaction ComPPI
PPP2R1A UQCRC2 25348397 N/A physical interaction ComPPI
KEAP1 UQCRC2 25348397 N/A physical interaction ComPPI
HSP90AB1 UQCRC2 25348397 N/A physical interaction ComPPI
TUFM UQCRC2 25348397 N/A physical interaction ComPPI
UQCRH UQCRC2 25348397 N/A physical interaction ComPPI
RAB10 UQCRC2 25348397 N/A physical interaction ComPPI
NDUFAF4 UQCRC2 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
SLAMF1 UQCRC2 25348397 N/A physical interaction ComPPI
JUN UQCRC2 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
TPM2 UQCRC2 25348397 N/A physical interaction ComPPI
SFPQ UQCRC2 25348397 N/A physical interaction ComPPI
VAPA UQCRC2 25348397 N/A physical interaction ComPPI
CTSD UQCRC2 25348397 N/A physical interaction ComPPI
DLD UQCRC2 25348397 N/A physical interaction ComPPI
HSP90AA1 UQCRC2 25348397 N/A physical interaction ComPPI
NTRK1 UQCRC2 25348397 N/A physical interaction ComPPI
NIT1 UQCRC2 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
RNH1 UQCRC2 21276451 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CANX UQCRC2 25348397 N/A physical interaction ComPPI
COPB1 UQCRC2 25348397 N/A physical interaction ComPPI
P4HB UQCRC2 25348397 N/A physical interaction ComPPI
PHB UQCRC2 25348397 N/A physical interaction ComPPI
HSP90B1 UQCRC2 25348397 N/A physical interaction ComPPI
C1QBP UQCRC2 25348397 N/A physical interaction ComPPI
UBR5 UQCRC2 25348397 N/A physical interaction ComPPI
CAD UQCRC2 25348397 N/A physical interaction ComPPI
CFTR UQCRC2 25348397 N/A physical interaction ComPPI
VDAC1 UQCRC2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
NFATC2 UQCRC2 25348397 N/A physical interaction ComPPI
TPM3 UQCRC2 25348397 N/A physical interaction ComPPI
PDHA1 UQCRC2 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RAB1A UQCRC2 25348397 N/A physical interaction ComPPI
RAB5A UQCRC2 25348397 N/A physical interaction ComPPI
RAB5B UQCRC2 25348397 N/A physical interaction ComPPI
RAP1A UQCRC2 25348397 N/A physical interaction ComPPI
RAP1B UQCRC2 25348397 N/A physical interaction ComPPI
PSMC5 UQCRC2 25348397 N/A physical interaction ComPPI
CLTC UQCRC2 25348397 N/A physical interaction ComPPI
HUWE1 UQCRC2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VDAC2 UQCRC2 25348397 N/A physical interaction ComPPI
ARF6 UQCRC2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SSR2 UQCRC2 25348397 N/A physical interaction ComPPI
ATP1A1 UQCRC2 25348397 N/A physical interaction ComPPI
ADRB2 UQCRC2 25348397 N/A physical interaction ComPPI
CACNA1A UQCRC2 21078624 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
VAPB UQCRC2 25348397 N/A physical interaction ComPPI
EGFR UQCRC2 25348397 N/A physical interaction ComPPI
HTT UQCRC2 17500595 24234451 25348397 association pull down ComPPI,IntAct
TCP1 UQCRC2 25348397 N/A physical interaction ComPPI
CCT7 UQCRC2 25348397 N/A physical interaction ComPPI
YAP1 UQCRC2 25348397 N/A physical interaction ComPPI
RTN4 UQCRC2 12067236 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
UBE2A UQCRC2 25348397 N/A physical interaction ComPPI
UQCRC2 UQCRC1 11073949 14525934 17353931 19688755 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,blue native page,in vitro ComPPI,HPRD,IntAct
UQCRC2 SLX1A 19596235 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UQCRC2 SNCA 25348397 N/A physical interaction ComPPI
UQCRC2 MRPL58 20186120 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UQCRC2 HDAC5 25348397 N/A physical interaction ComPPI
UQCRC2 SIRT7 25348397 N/A physical interaction ComPPI
UQCRC2 TCF3 25348397 N/A physical interaction ComPPI
UQCRC2 KCND3 25348397 N/A physical interaction ComPPI
UQCRC2 FBXO6 25348397 N/A physical interaction ComPPI
UQCRC2 ATP5PF 25348397 N/A physical interaction ComPPI
UQCRC2 FKBP8 25348397 N/A physical interaction ComPPI
UQCRC2 NCL 25348397 N/A physical interaction ComPPI
UQCRC2 SRSF5 25348397 N/A physical interaction ComPPI
UQCRC2 ZNF326 25348397 N/A physical interaction ComPPI
UQCRC2 CLN3 25348397 N/A physical interaction ComPPI
UQCRC2 CCDC8 25348397 N/A physical interaction ComPPI
UQCRC2 FAF2 25348397 N/A physical interaction ComPPI
UQCRC2 UQCRB 25348397 N/A physical interaction ComPPI
UQCRC2 AFG3L2 25348397 N/A physical interaction ComPPI
UQCRC2 ATAD3A 25348397 N/A physical interaction ComPPI
UQCRC2 ATP5F1A 25348397 N/A physical interaction ComPPI
UQCRC2 ATP5F1C 25348397 N/A physical interaction ComPPI
UQCRC2 CCT8 25348397 N/A physical interaction ComPPI
UQCRC2 DDX39B 25348397 N/A physical interaction ComPPI
UQCRC2 HNRNPA3 25348397 N/A physical interaction ComPPI
UQCRC2 IDE 25348397 N/A physical interaction ComPPI
UQCRC2 NDUFA12 25348397 N/A physical interaction ComPPI
UQCRC2 NDUFA9 25348397 N/A physical interaction ComPPI
UQCRC2 NDUFB8 25348397 N/A physical interaction ComPPI
UQCRC2 NDUFS1 25348397 N/A physical interaction ComPPI
UQCRC2 NDUFS3 25348397 N/A physical interaction ComPPI
UQCRC2 NDUFS4 25348397 N/A physical interaction ComPPI
UQCRC2 PRKCSH 25348397 N/A physical interaction ComPPI
UQCRC2 RAB1C 25348397 N/A physical interaction ComPPI
UQCRC2 RAB1B 25348397 N/A physical interaction ComPPI
UQCRC2 RAB6B 25348397 N/A physical interaction ComPPI
UQCRC2 SCD 25348397 N/A physical interaction ComPPI
UQCRC2 SCD5 25348397 N/A physical interaction ComPPI
UQCRC2 SEC61A1 25348397 N/A physical interaction ComPPI
UQCRC2 SSR3 25348397 N/A physical interaction ComPPI
UQCRC2 SSR4 25348397 N/A physical interaction ComPPI
UQCRC2 TMCO1 25348397 N/A physical interaction ComPPI
UQCRC2 ACADM 25348397 N/A physical interaction ComPPI
UQCRC2 ALDH1B1 25348397 N/A physical interaction ComPPI
UQCRC2 ALDH2 25348397 N/A physical interaction ComPPI
UQCRC2 CCT3 25348397 N/A physical interaction ComPPI
UQCRC2 CCT6A 25348397 N/A physical interaction ComPPI
UQCRC2 CCT6B 25348397 N/A physical interaction ComPPI
UQCRC2 CYP27A1 25348397 N/A physical interaction ComPPI
UQCRC2 DDOST 25348397 N/A physical interaction ComPPI
UQCRC2 DKC1 25348397 N/A physical interaction ComPPI
UQCRC2 EHD4 25348397 N/A physical interaction ComPPI
UQCRC2 ETFA 25348397 N/A physical interaction ComPPI
UQCRC2 GANAB 25348397 N/A physical interaction ComPPI
UQCRC2 HADHB 25348397 N/A physical interaction ComPPI
UQCRC2 HNRNPM 25348397 N/A physical interaction ComPPI
UQCRC2 HSD17B12 25348397 N/A physical interaction ComPPI
UQCRC2 HSP90AA2P 25348397 N/A physical interaction ComPPI
UQCRC2 IDH3A 25348397 N/A physical interaction ComPPI
UQCRC2 IPO5 25348397 N/A physical interaction ComPPI
UQCRC2 LMAN1 25348397 N/A physical interaction ComPPI
UQCRC2 MRPL37 25348397 N/A physical interaction ComPPI
UQCRC2 MTCH2 25348397 N/A physical interaction ComPPI
UQCRC2 MT-CO2 25348397 N/A physical interaction ComPPI
UQCRC2 NDUFB5 25348397 N/A physical interaction ComPPI
UQCRC2 NDUFB7 25348397 N/A physical interaction ComPPI
UQCRC2 NDUFS8 25348397 N/A physical interaction ComPPI
UQCRC2 PC 25348397 N/A physical interaction ComPPI
UQCRC2 PSMC1 25348397 N/A physical interaction ComPPI
UQCRC2 RAB5C 25348397 N/A physical interaction ComPPI
UQCRC2 RANBP2 25348397 N/A physical interaction ComPPI
UQCRC2 RPN2 25348397 N/A physical interaction ComPPI
UQCRC2 RPSA 25348397 N/A physical interaction ComPPI
UQCRC2 SDHB 25348397 N/A physical interaction ComPPI
UQCRC2 SSR1 25348397 N/A physical interaction ComPPI
UQCRC2 TECR 25348397 N/A physical interaction ComPPI
UQCRC2 UQCRQ 25348397 N/A physical interaction ComPPI
UQCRC2 GOLT1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UQCRC2 SKI 25348397 N/A physical interaction ComPPI
UQCRC2 NDUFA4 25348397 N/A physical interaction ComPPI
UQCRC2 PTPMT1 25348397 N/A physical interaction ComPPI
UQCRC2 CISD3 25348397 N/A physical interaction ComPPI
UQCRC2 NMES1 25348397 N/A physical interaction ComPPI
UQCRC2 COQ9 25348397 N/A physical interaction ComPPI
UQCRC2 ZNF746 25348397 N/A physical interaction ComPPI
UQCRC2 PPM1E 25348397 N/A physical interaction ComPPI
UQCRC2 STOM 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
UQCRC2 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
UQCRC2 DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
UQCRC2 SDHA 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
UQCRC2 SOAT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
UQCRC2 TARDBP 25348397 N/A physical interaction ComPPI
UQCRC2 HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
UQCRC2 RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
UQCRC2 OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation ComPPI,IntAct
UQCRC2 NFKB1 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
UQCRC2 AIFM1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
UQCRC2 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
UQCRC2 NDUFAF8 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
UQCRC2 MICOS13 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
UQCRC2 COX6B1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
UQCRC2 COQ10A 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
ATF2 UQCRC2 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
COX4I1 UQCRC2 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
DUSP21 UQCRC2 25348397 N/A physical interaction ComPPI
COX5B UQCRC2 24234451 30021884 physical association cross-linking study IntAct
NLRX1 UQCRC2 19692591 27898060 N/A N/A OmniPath

Visualization










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