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GENE：UBE2L6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol UBE2L6
FullNmae ubiquitin conjugating enzyme E2 L6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12490
EnsembleID ENSG00000156587
Uniprot O14933

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
UBE2L6 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
UBE2L6 GO:0000151,GO:0000209,GO:0004842,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006511,GO:0016567,GO:0031625,GO:0032020,GO:0032020,GO:0036211,GO:0042296,GO:0042296,GO:0043130,GO:0045087,GO:0061631

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
UBE2L6 hsa:9246 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
UBE2L6 hsa:9246 path:hsa05012 Parkinson disease - Homo sapiens (human)
UBE2L6 hsa:9246 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
RNF125 UBE2L6 17460044 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
ISG15 UBE2L6 16009940 23180781 physical association unspecified method InnateDB

Source Target Pmid Interactiontype Methods Database
YBX1 UBE2L6 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 UBE2L6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF UBE2L6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 UBE2L6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
UBE2L6 SIAH2 25361965 interaction type N/A PTMCode2
SIAH2 UBE2L6 25361965 interaction type N/A PTMCode2
UBE2L6 TRIM25 25361965 interaction type N/A PTMCode2
TRIM25 UBE2L6 25361965 interaction type N/A PTMCode2
UBE2L6 RNF19B 25361965 interaction type N/A PTMCode2
RNF19B UBE2L6 25361965 interaction type N/A PTMCode2
UBE2L6 ARIH1 25361965 interaction type N/A PTMCode2
ARIH1 UBE2L6 25361965 interaction type N/A PTMCode2
RNF125 UBE2L6 25361965 interaction type N/A PTMCode2
UBE2L6 RNF125 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
RNF40 UBE2L6 12121982 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
UBA7 UBE2L6 25348397 N/A physical interaction ComPPI
ISG15 UBE2L6 25348397 N/A physical interaction ComPPI
TYK2 UBE2L6 25348397 N/A physical interaction ComPPI
XIAP UBE2L6 25348397 N/A physical interaction ComPPI
RAD21 UBE2L6 25348397 N/A physical interaction ComPPI
MCM2 UBE2L6 25348397 N/A physical interaction ComPPI
SIAH2 UBE2L6 11786535 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CBLC UBE2L6 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ARHGDIA UBE2L6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SIAH1 UBE2L6 25348397 N/A physical interaction ComPPI
RBX1 UBE2L6 25348397 N/A physical interaction ComPPI
HERC5 UBE2L6 25348397 N/A physical interaction ComPPI
UBB UBE2L6 25348397 N/A physical interaction,comigration in sds page ComPPI
UBC UBE2L6 25348397 N/A physical interaction,comigration in sds page ComPPI
RPS27A UBE2L6 25348397 N/A physical interaction,comigration in sds page ComPPI
UBA52 UBE2L6 25348397 N/A physical interaction,comigration in sds page ComPPI
UBA6 UBE2L6 25348397 N/A physical interaction ComPPI
TOPORS UBE2L6 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NEDD4L UBE2L6 25348397 N/A physical interaction ComPPI
FLT3 UBE2L6 25348397 N/A physical interaction ComPPI
RNF19A UBE2L6 11237715 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FLNB UBE2L6 19270716 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
MID1 UBE2L6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKN UBE2L6 11078524 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PJA2 UBE2L6 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TIMM8A UBE2L6 25348397 N/A physical interaction ComPPI
RNF4 UBE2L6 25348397 N/A physical interaction ComPPI
UBA1 UBE2L6 25348397 N/A physical interaction ComPPI
SPEN UBE2L6 14525934 16583136 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
TRIM25 UBE2L6 12075357 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
UBE2L6 ARIH1 10521492 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
UBE2L6 RNF216 14525934 15107846 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach ComPPI,HPRD,IntAct
UBE2L6 RNF144B 14525934 16427630 19549727 19690564 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid array,in vitro ComPPI,HPRD,IntAct
UBE2L6 MAP3K1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2L6 RNF122 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2L6 RNF150 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2L6 RNF25 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2L6 RNF125 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2L6 TRAF7 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2L6 DTX3 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2L6 RNF144A 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2L6 RBCK1 19549727 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBE2L6 LONRF1 19549727 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UBE2L6 TRIM8 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2L6 TRIM27 19549727 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2L6 RNF19B 16709802 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBE2L6 RUNX1 25348397 N/A physical interaction ComPPI
UBE2L6 UBE3A 10558980 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
UBE2L6 BIRC2 25348397 N/A physical interaction ComPPI
UBE2L6 HERC6 25348397 N/A physical interaction ComPPI
UBE2L6 NAMPT 18486613 24234451 25348397 physical association two hybrid ComPPI,IntAct
UBE2L6 SNURF 19690564 24234451 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
UBE2L6 TRIM62 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ARIH2 UBE2L6 19549727 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MUL1 UBE2L6 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ISG15 UBE2L6 16009940 27898060 N/A N/A OmniPath
UBE2L6 RNF125 17460044 19549727 27898060 N/A N/A OmniPath

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